Abstract:Objective: To recognize changes in the contents of ingredients of Andrographis Tablet in the process of production. Method: Adopting TLCS,TLC,HPLC to detect effective contents of ingredients which are produced in every stage of process of Andrographis Table‘s production. Result: Handling with the fresh Herba Andrographis according to current pharmacopeoia‘s technology, it showed that only dehyandrographolide can be detected. It indicated that the main factor that leads to chemical change is the heating process in the process of production. Conclusion: Avoiding heating treatment or reducing heating treatment time is the main factor to protect the effective ingredients.