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期 刊 ：中国中药杂志 1998年 23卷 11期 页码：680.

关键词：墨旱莲；化学成分；药理活性；

Keywords:Eclipta prostrata, chemical constituents, pharmacological action,

摘 要 ：目的:中药墨旱莲植物抗肝炎活性成分的研究。方法:醇提、硅胶柱层板法分离及药理活性筛选。结果:分离得到4个化合物,经光谱学分析鉴定了其中2个化合物,分别为豆甾醇(stigmasterol,Ⅰ)和α-三噻吩(α-terthienyl,Ⅱ)。结论:化合物Ⅱ为首次从该植物中分得,。初步药理实验表明,墨旱莲醇提物的乙酸乙酯部分对CCl₄诱发的小鼠肝损伤有明显的肝保护作用。

Abstract:Objective:To study the pharmacologically active components of Eclipta prostrata.Method:The components were extracted by alcohol and isolated by silica gel column and subjected to pharmacological screening.Result:Four compounds were isolated from E.prostrata, of which two were identified as stigmasterol and α-terthienyl. Conclusion:α-Terthienyl was isolated from the plant for the first time.The EtOAc part of alcoholic extraction exhibits significant hepatoprotective activity against carbon terachloride induced liver injury in rats.

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