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期 刊 ：中国中药杂志 1999年 24卷 04期 页码：232.

关键词：中药复方；钙拮抗剂；同位素45Ca；

Keywords:complex prescription, calcium antagonist, radionuclide 45 Ca,

摘 要 ：目的：探索中药复方化痰愈心汤及功能药组的钙拮抗作用。方法：用^４５Ｃａ跨膜技术测量大鼠主动脉３种钙通道的Ｃａ^２＋内流影响。结果：当复方浓度为０．５～５ｍｇ／ｍｌ时，能阻滞大鼠主动脉ＲＯＣ和ＰＤＣ的Ｃａ^２＋内流；功能药组的钙拮抗作用以活血组和行气组较好。结论：化痰愈心汤治疗冠心病的机理可能与阻滞细胞膜外Ｃａ^２＋内流有关，其作用规律与Ｖｅｒａｐａｍｉｌ相似。

Abstract:Objective:To study the Ca ²⁺ antagonistic effect of functional groups of Huatanyuxin decoction.Method:The ⁴⁵ Ca transmembrane influx technique was used to measure the Ca ²⁺ blocking effect of leak,receptor operated Ca ²⁺ channel (ROC) and potential dependent Ca ²⁺ channel (PDC) in rat aorta.Result:ROC and PDC could be blocked when the complex prescription was used at concentrations of 0.5～5mg/ml.Among the functional groups,Huoxue group (activating blood) and Xinqi group (promoting and normalizing flow of vital energy)showed better Ca ²⁺ antagonistic effect.Conclusion:The mechanism of therapeutic effect of Huatanyuxin decoction may be related to its Ca ²⁺ blocking effect similar to verapamil.

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