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期 刊 ：中国中药杂志 1993年 18卷 06期 页码：347.

关键词：十大功劳；盐酸小檗碱；提取工艺；正交试验；

Keywords:Mahonia bealei, berberine hydrochoride, processing mcthod, regressive test,

摘 要 ：用正交试验对十大功劳提取盐酸小檗碱的工艺进行研究。结果表明:A₂B₈C₁D₂E₃F₂即提取溶剂用0.5%硫酸,盐析用24%食盐,浸提温度为25℃,浸泡时间为48h,提取液调PH1.5,沉淀放置24h为最佳工艺条件。应用该工艺提取,总碱(以盐酸小檗碱计)收率为1.45%～1.47%。

Abstract:The article reports the processing methods for extracting berberine hydrochoride from Mahonia bealei by means of regressive test. The result shows that A₂B₃C₁D₂E₆F₂ is the heat way, namely, extractive solvent—0.5% sulfuric acid, salting out—24% salt, soaking temperature—25℃, soaking time—48hours, pH=1.5, precipitation time—24 hours. The recovery is 1.45%～1.47%.

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