Abstract:The use of water extract(ip or ig ) of Valeriana jalamansii together with pentobarbital sodium can enhancesedative and hypnotic effect in mice,inhibit the spontaneous activity in mice , and antagonize convulsive action in-duced by thiosemicarbazide(TSZ).Although ineffective on the convulsion induced by picrotoxin(PT),it can pro-long the latent period of convulsion induced by PT in mice. The number of writhings in mice can be reduced af-ter ip or ig water extract.