Abstract:The co-precipitate has been made from berberine bisulfate and polyvingl pyrrolidone (PVP) with theratio of 1 : 5. The liposomes entrapped berberine bisulfate have been prepared with the ration of drug to lipid 1 : 20and the ratio of cholesterol to soy phosphatide 2 : 7. The percentage of encapsulation is 48. 72%. The test in vivo ofsmall intestinal absorption in rats shows that liposomes can increase the abserption by 4-fold odd compared with freeber-berine bisulfate.