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期 刊 ：中国中药杂志 1991年 16卷 09期 页码：557.

关键词：丹皮酚；培养乳鼠心肌细胞；钙反常；45Ca摄取；过氧化脂质；

Keywords:paeonol, cultured neonatal rat heart cells, calcium paradox, 45Ca uptake, lipid peroxide,

摘 要 ：丹皮酚能显著抑制正常心肌细胞快相(5min)和慢相(120min)⁴⁵Ca摄取及搏动频率,显著抑制钙反常心肌细胞⁴⁵Ca摄取和降低胞内过氧化脂质含量,且呈剂量依赖性。表明丹皮酚减轻钙反常损伤与阻止Ca²⁺内流及抗氧化有关。

Abstract:It has been found that the rapid (5min) and slow (120min) phases of ⁴⁵Ca uptake by normal myocardial cells and their beating rate are remarkably inhibited by paeonol. And that paeonol can also decrease ⁴⁵Ca uptake and lipid peroxide in calcium paradoxical heart cells, which appears in dose-dependence. This indicates that the mechanism of protection of paeonol against calcium paradox is associated with its inhibition of Ca2+) influx and antioxidation.

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