Abstract:Objective To optimize the formulation and process development of Yinhuang orally disin- tegrating tablets.Methods Powder of Flos Lonicerae has unpleasant taste,so fluid-bed coating method with Eudragit El00 as coating material was applied to masking the bitter and astringent taste of the pow- der.The orthogonal design was adopted to optimize the tablet formulation.The yield of granulea,tensile strength,and disintegration time were determined as the index.The high stirring and fluid-bed granula- tion processes were studied.Results The optimal conditions were:The powder of Flos Lonicerae had pleasant taste with 10% weight getting after coating.Crosspovidone PVPP was used as disintegratant, making up 10% of the weight in the total prescription,of which 50% was added outside and inside of the tablets,respectively.After granulated by fluidized bed,Yinhuang bulk powder was granulated and then tableted.Conclusion The disintegration time and tensile strength of Yinhuang buccal disintegrating tablet are better and the taste is satisfactory.Yinhuang buccal disintegrating tablets reach the design stan- dard.