---

作 者 ：房信胜,王建华,穆象山,周红英,李作凤

期 刊 ：中草药 2009年

关键词：丹参素微囊；喷雾干燥；体外释放；

Keywords:danshensu microcapsule, spray drying, in vitro release,

摘 要 ：目的采用喷雾干燥法制备丹参素微囊。方法以包封率为指标,比较不同囊材的包封情况;以微囊产率为指标,采用二次回归通用旋转组和设计确定喷雾干燥条件;对制备的微囊进行体外释药研究。结果以PVA作为囊材,囊材与药物比例为3:1,喷雾干燥条件为进风温度190℃,蠕动泵进样速率36 r/min,微囊包封率为85.0%,产率为56.1%,70%以上微囊粒径在6～12μm。结论制备丹参素微囊工艺合理,产品具有一定的缓释效果。

Abstract:Objective To prepare sustained-release danshensu microcapsules by spray drying.Methods Encapsulation efficiency of different coating materials was compared.The spray process was optimized using a central composite design for two variables to obtain microcapsules with microcapsules yield.Furthermore，in vitro release of danshensu microcapsules was determined. Results PVA was chosen as coating material and the ratio of coating material to core material was 3:1.The inlet air temperature was 190℃,the feed flow rate was 36 r/min，encapsulation efficiency was 85.0%,and microcapsules yield was 56.1%.The particle size of more than 70% microcapsules was between 6-12 p.m.Conclusion The optimized conditions of spray drying are reasonable, danshensu microcapsules can be used as sustained-release preparatton.

---