Abstract: Objective To establish an optimal extracting method of Sichen Zhike Granula. MethodsThe extracting method of Sichen Zhike Granula was optimized by orthogonal design,taking the extractionrate of bergenin, glycyrrhizic acid,and chlorogenic acid and extract yield as indexes. Results The optimal extracting method was reflux extracted twice(1h/time) with 10 and 8 times the volume of 60%ethanol,respectively; The medicinal materials were soaked for 2 h before the extraction. Conclusion The optimal technology is reasonable and suitable for the extraction process of Sichen Zhike Granula.