Abstract:Abstract: Silk fibres and silk-based materials，such as spider and mulberry silkworm silk fibres，have been widely used in tissue engineering and biomedical application due to its good biocompatibility. The content of this review is to discuss the recent progress in the research on the fabrication of silk scaffold, cellular compatibility in vitro as well as the implantation in vivo with silk fibres. Key words: tissue engineering; silk scaffold; cell culture; biocompatibility