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作 者 ：王崑仑;赵修华;祖元刚*;李家磊;李汶罡

期 刊 ：植物研究 2011年 31卷 4期 页码：508-512

关键词：超微粉；三七总皂苷；理化性质；高效液相色谱；

Keywords:submicron powder, Panax notoginseng saponins, physicochemical property, HPLC,

摘 要 ：通过对药用植物三七总皂苷原粉和超微粉的粉体粒度、电位、显微结构、红外光谱、溶解速度这几项理化性质的研究，判定两种粉体的优劣，为三七总皂苷超微粉的市场推广提供依据。实验结果表明，三七总皂苷原粉经纳米化处理后成为三七总皂苷超微粉，其化学结构没有发生变化，但显微结构从条状的晶体变为由纳米球紧密排列的不规则形态，其粉体平均粒径也从1 122.4 nm缩小到153.4 nm,完成了从微米到纳米的转变，其水溶液也变为稳定的胶体溶液。运用高效液相色谱法，在模拟人体环境的条件下，发现三七总皂苷超微粉比三七总皂苷原粉早1 min完全溶解。说明三七总皂苷超微粉比三七总皂苷原粉颗粒更小，更易溶于水，更易与人体吸收。

Abstract:To assess the advantages and disadvantages of Panax notoginseng Saponins original powder and submicron powder, and provide basis for the marketing of P.notoginseng saponins submicron powder, the physicochemical properties of two powders including particle size, electric potential, microscopic structure, infrared spectrum and dissolution velocity were studied The experimental results indicated that P.notoginseng saponins original powder turned into submicron powder after nanocrystallization without chemical structure change. Its microscopic structure was changed from banded crystal to irregularly shaped nanospheres arranged closely, its powder average particle size was shrinked from 1 122.4 nm to 153.4 nm, finishing the shift from micron to nanometer, its water solution was changed from true solution to stable colloidal solution. Using HPLC, under the condition of simulated human environment, it was found that P.notoginseng saponins submicron powder dissolved completely 1 min earlier than original powder. The experiment results showed that P.notoginseng saponins submicron powder is smaller than original powder in particle size, more soluble in water and more usable for human body.

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