Abstract:The cucumber powdery mildew resistance was studied with joint analysis of multip le generations. The best fitted model of three resistant suscep tible crosses was two major genes plus polygenes mixed inheritance model ( E2120 model) without excep tion. In cross I, heritabilities ofmajor geneswere 64.26% -95.47%. Formajor genes, susceptibilitywas the dominant partly. The additive effects of the two major genes and the dominant effect of the second major gene were higher. The ep istatic effect of additive ×dominant of two major genes was higher too. The heritabilities ofmajor genes in the crossⅡ and cross Ⅲ were 96.04% and 95.35% , respectively. The additive effect, dominant effect and dominance degree of two major genes were similar in this two crosses.