免费文献传递   相关文献

Protective effect of oxymatrine on chronic heart failure and ADMA metabolism pathway in isoproterenol-induced chronic heart failure in rats

氧化苦参碱抑制异丙肾上腺素诱导大鼠慢性心力衰竭及对ADMA代谢通路的影响



全 文 :!j<
!
!™áÖBC}DEFØGHIJKLM2
UNOP”Q
3A93
R¸BPƒRS


!
0Ï
*
!
MÄ]
*
!
ÅÆÇ

!
tR

!
ÈR
*
!
VÉ>
)
!
0Ê7
*
!
e
ùÄgUuç XçV Xmçp
!
ùÄ Å–
%$$$&%
*e
ùÄgUuç ÆgV yÇU
!
ùÄ Å–
%$$$&%
)e
ÈÉçV _牐ÊcdçV QXcdp
!
ɑ ÈÉ
#$#
!!

tu
#!

#
•–!™áÖBC}DEFØGH
!:8C
IJKLM2UNOP”öQ Q„2ø—°l6
!3A93
R¸BPƒRS
(
ab
#
–2
8]@KRWO5AK+VO6
KL
$
Vʀé
:8C /R/\R
r
/U
r
$
£Ý,
% U
IcKLM2UNOP
(
!
™áÖB
!$$$$ /R/\R
r

˜
:8C
ێY
% U
iwÝ,
$
§
& U(
x#˨~
%
UdeÃj¢NÖ?
%
Uez{
$
”Â
ÃUs©aʼnA™
$
\Qw§
POJSO@1 _V.S?1R
‡#þðXüƒ8¦
(
›œ
#
!™áÖB
!$$$$ /R/\R
r

e./wx
:8C
IJƒUNOPKLOƒËUss!Xü
:!-B1 :
ȱ
$
fgŸUâŸïÝZ[de”ŸUâ)
$
./Ì&
:8C
kKLUsƒÅ‰fA
(
Šewx
:8C
IJUNOPKLË
3A93
@{
!Hu$e$$
´6Uâs©a$2ø—2øÙÈ
‘]
*!AA3[*
Xüƒ8¦
!Hu$e$$
‡Q
:8C
IJOƒXü°l6ø—œ|]
!D>9B
RS
(
›S
#
!™áÖB
efg
:8C
IJƒM2UNOPKLƒUde
$
C}Uâ)
$
ö¦§‘}…wxË
3A93
ȱݴÂUs©a
AA3[*
8¦È±Dð
(

vwx
#!
!™áÖB
)
DEFØGH
)
M2UNOP
)3A93)D>9B)AA3[*

yz)(
#!*$)55$#

{|}P
#!
% ¨W&—ËÜ
!($#$$*&

~r€
#!
!
²‹Ï
$
,ÙECÐ
$
,uv
$
œ
$
êJÐ
$
BOV#!$4#%&&*$$I5/K?V# 7W5c_2#),-./

€ˆ‰
#!
!S
$
ꝋŒ
$I5/K?V#1?-\,16O5$))2#),-./
!!
!™áÖB
!.76/KS@?1O
­ÆáÖH
$
֋$&
—×¾¿ŸÞìïÙ,Rá$Ç
6$0/$ )$0&+*2
$,%&-Ee
$烽Q~DžOúNþÜ_ƒ
¿B
(
~Dÿ#
%
…\ÝÿÉÊ!­Q,‰¦
§
,-
$
öQUÃ$€½ƒ¦§aØ./
,5*-
(
‹Œ
84
$
!™áÖBeȪŸaÌ¢ËYwE_˜
ákr2UsÃKLUsµqJ¬
$
C}UsÑ
Òno
,)-
(
M2UNOP÷nQUe9őخ
)ƒ$)
$
öcÅ&Ýqo&¿tÂ
,&-
(
Ë Q
„22ø—°l6
!3A93
ȱ…nÜUÃ$äZ
ƒcÞ^þð
$
”dØ÷ÚcUÃ$äZƒ(ô
ÖËÆÇ[½
,5#-
(
³´”¢¿84
$
UNOP
·àݵ¢¿ŽbË
3A93
@{¿./O
Â
,%5(-
(
鏐EŸÖ
:8C
IJKLM2UNOP
؎b
$
‹Œ!™áÖBQKLM2UNOPƒC
}¦§”öQ
3A93
R¸BPƒRS
(
!
RU
^!
¢¿
!
‹kc–2
8]@KRWO5AK+VO6
KL
$
y)
*$ h*$ R$
=ŸÞC&K¢¿$Uç…
$
¢
¿ˆ@`<
8Ÿ
*$*5$$$(
^!
,0ݵÍ
!
!™áÖB
!
ŸÞDcÓ,%
DEFG
$
¥ñ
44e(f$
<
*$$4$*()
DEFØ
GH
!:8C$
ØJøM»DEFG
$
¥ñ
n44e$f$

<
9^ 8BG5;G)
Uss!Xü
:!-B1 :$3A93
]
¥UVèux#µÍ%
!
•–]cµÍDEFG
)
ñA¼
%
.™™
%
­íøC
!8?R/K
FG
)
Á—mX
üçµÍ%
%
Á—
X<3
Xü@{x#µÍ%
!
9
3Á—¿&(c“DEFG
)
¡ÿÔ®
D>9B
ÝÔ®ÿ¡
AA3[*
ÿy
!3_-K/
FG
)
:Lÿ
!
5K-S?1
ÿy
!
23$¸Ës¿()FG
(
Ô®ÿ
¡
%
¡ÿÔ®ÝÔ®ÿ:L2ÿ
!
23$¸Ës
¿()FG
( 8W]O@8?R1KVPOJSD?-.-O1S8W_JS@KSO

BMO@/.8-?O1S?T?-
FG
)
§È
Ø=¥È
(
&^!
dD
!XE5&*$I
žÂ¿‘e€½
!
š
/%&/
t
)4
Çt
)
v
*$&
o
*
p
!!!!!! ! ! ! ! ! !!!! ! ! ! !
.^Ve)4$:JJWO!)
GO_@WK@6$ *$&
šÐ&(DEFG
)BQ4#5
!
;
b=ÑÒËt‘
!
Ÿ½B¿&(dBDEFG
)[($>
bB
Â﹦|U‘
!
Ç0¸d|U‘dDDEF
G
)9WS?J\K1 H.
]~d
!
c%
BMO@/.G?JMO@
F
G
)D.+O@DK-XKJ?-
W`d
!
c%
X:C5>3A
FG
)
ù‹
Y85(#$X
꫚țÔd
!
ØJù‹&(DE
FG
(
!
†‡
^!
M2UNOP¢¿Žbƒ}“”›©
!#$
©
KL
$
®‘›Ø

©
$

*
©
$
›Ä÷
#
^ŒQ²
©
!<.1S@.V%
¾§!™áÖB©
!$$ /R/\R
r
%
:8C
©Ý!™áÖBÂ
%
xÍ{©
!$$$$ /R/
\R
r
(
:“g
,4-$
w§Vʀé
:8C /R/
\R
r
/U
r
$
£€é
% U
‚ôM2UNOPKLŽ
b
(
!™áÖBn©Ý
:8C
©Vʀé
:8C /R/
\R
r
$


I
$
£
% U(
Q²©Ý¾§!™áÖ
B©KLVʀéþuyª‰ÞÈ
(
ÖØn©¿
˜
:8C
ێY
% U
iwÝÀ!™áÖB
$
§
& U$
i
wÝ,yªØ
/E/\R
r
(
Q²©Ý
:8C
©iw
ÝÀ!yª‰ÞÈ
(
^!
UdeÃj¢NÖ?ƒ#
!
n©¢¿²
IÝ,ãri—rÈ
*& M$
„y)
$*$f
ñA¼
!#
/E/\R
r
$,0

(
˜j13È5dLÌÝO
$
›
|èÈjk¢Ë
$
_˜Uª
$
§KL¢ËkМê

$
˜õª8‡ŒÃ$”ì@D\H‰ÞÈ
!$$ /`/E
r

ƒUJ$
!DI$
ÅÈjk¢Ë
$
ˆ
Œ¢Ëk
$
BŽÄN#eD£X
XE5&*$I
žÂ
¿‘eQŽd
$
QŽ¢ËÃÄA™
#
¢ËŸïÄ
!83D%
¢ËZ[Ä
!8AD%
±¿¢ËÄ
!93D$
V
ãQŽ
/?1$
Wãˆj¢ËÌU†Ì@J$&
&ì
) h&e -/$
å¢ËÄN½­WWDK]ñ
ƒA™
%
Z[Ä4.ÊwQ
$
Ù4J$9’ìŸU
â
$
VãQŽŸUâŸïÄ
!VOTSNO1S@?-WVK@J6JS.V?-
]@OJJW@O$E^ 8D%
ŸUâÄN‘KØO
=
Êwï&
! oE^ U0=U3
/K7
=rE^ U0=U3
/?1
%
U&
![>
!
(
&^!
mUz{
=
y)s-”ŸUâz{
=
y)s-
#
!
n©¢¿ŸÃãôÁ]q
$
Œ’Ue
$
„
mU6)
$
ˆaÌr…d›|ŸU┄)
(
˜¤
mUz{
=
y)ƒs-ݟUâz{
=
y)ƒs-
(
)^!
ËUss!Xü
:!-B1 :
Ý
3A93
ȱƒ
#
!
mØ
# $$$ t1
|U
/?1$
Ë
$
®@
Ų
IE:83
µÍ%X Ù4háކ‡‰¦
$
x#
Ë
-B1 :
Ý
3A93
ƒ@{
(
$^!
ʼn©aÂÃ
!
ÝUž©a
$
‚˜
$f
$2øCÅ
*& M$
+“Ÿ
$
ÝÒ
&
(
/$
dŒÍ
[I

$*$$ t
“xÂÃ
(
Ö²“g
,$-$
@Us
ʼnƒ„›Ø
&
c
#$
c
! r$
UsÑÒ_‹²
$
UstuWÈxV
$
Ô±‹†
$
#ÑÒÍD
$
Ñ
ÒÈÉ
%
#qhtu™
$
Az|ÑÃ$X[h&ñ
X[
):
c
! o$
UsÑÒWÈ͏
$
„{#ÑÒÍ
D
%
UsÑÒÈÉ
$
AzÃ$X[
$
Us©aeqe
 2tu™
$
E˜U8WÊ
)
!c
!
&
$
t­#ÑÒ
ÍD
$
UsÑÒÈÉ
$
UsÑÒtu™ÞỜe
$
«
”U§m;
$
Azeq4.Ã$X[
)
&c
!

$
D4
.ƒAzÃ$X[
%
Èɔ#ÑÒÍD
$
Us=ð2K
Ѫtu™
$
 Aþ^£«”U§m;
(
\^!POJSO@1 _V.S?1R
x#
!
٦
$ /R
Ïm¨‹
¡ƒUs©a$6ì
$e) /E
¹=‘Íùm
$
B%Ê
=!1tÑÒ
( & p$
š
@//?1
r
|U
$ /?1$

؋Xü{
$
‰È؋m6ìØÀÍùm
$$ p
È%
$ /?1$ r*$ p
…¼
(
XüÀé
#$
(
R
Ø
À
$$f8A85D3HI
ê«W`
!($ =^*$ ^

$
*$$ /3
)WjœWń6tuHW
$f
#¯¢
ËМ
M
ã
$
›Ä§ÿ
D>9B
ÿy
!g)$$%
ÿ
AA[3*
ÿy
! g)$$
”ÿ !
5K-S?1
ÿy
!

$
g $$$& p
lmŽ“
(
›Ä6ìÔ®ÿ¡
%
¡ÿ
Ô®2ÿ
!
1¥D
[>D$g) $$$
Ý¡ÿ:L2ÿ
!
1¥D
[>D$g $$$
Δlm
* M$
6ì=c™
cêX¿èum
$
£ê«Ò
(
«Òm®_,w§
FWK1S?S65.1O
uZ›Ô
$
@܃Yރžêñ…öþ
Quƒ8Ö !
5K-S?1
ƒžêñþsÖß^ÓÃ
$
á_
s-R8¢ÜƒXüƒþQ@{
(
%^!
½˜]‰
!
_,Ö
8D88 e
½˜›
ÔuZ“’d›Ô
$
?Ö (
Ps-
8I
$
­©A¿?
ƒstw§
C1O5+K63;C^ 3
›Ô
$Hu$e$
ؼŸ
½˜ÃDƒE
(
&!
_,
& ^!
!™áÖBQUsƒ„~.¿
-B1 :
ƒRS
!
¾§!™áÖB©…Q²©þsË
-B1 :
.
/2ÃD
(
…Q²©þs
$:8C
©Ã‹
-B1 :
ȱO
Â
!Hu$e$$
çI
:8C
JkKLUsƒ„
(

áÖB
!$$$$ /R/\R
r

©Ã‹
-B1 :
@{4.
wx
!Hu$e$(
çI!™áÖBQUsƒ„~D
…†¦§
$
qg
(
/*%&/
t
)4
Çt
)
v
*$&
o
*
p
!!!!!! ! ! ! ! ! !!!! ! ! ! !
.^Ve)4$:JJWO!)
GO_@WK@6$ *$&
…Q²©þs

Hu$e$)
…Žb©þs
*
Hu$e$!
g
)$&
(
g
!
!™áÖBQ
:8C
IJM2UNOPKLË
-B1 :
ƒRS
!
(
Ps-$#z(
G?Re!ITO-S.T.76/KS@?1O.1 VONOV.T-B1 :?1 :8C5?1UW-OU
-M@.1?-MOK@STK?VW@O?1 @KSJ!
(
Ps-$#z(
& ^!
!™áÖBQ
:8C
IJM2UNOPKLÃ
!!
j¢Nƒfg
!
¾§!™áÖB©…Q²©þ
s
$
Ãj¢Nn¨~¿./ÃD
(
Žb©…Q
²©st
$
U&
![>$83D$93D$E^ 8D$oE^U0=U3
/K7
¿wx
!Hu$e$$rE^U0=U3
/?1
´Â
!Hu$e$(
ç
I
:8C
ewx¢ËÃÄÝUsZïde
(
ÝÀ!™
áÖB
!$$ /R/\R
r

©
83D$93D$E^ 8D
4.´Â
!Hu$e$$[>
Ý
oE^ U0=U3
/K7
´Â
!Hu$e$$
rE^ U0=U3
/?1
4.wx
!Hu$e$(
!™áÖB
!$
/R/ \R
r

©
[>$ 83D$ E^ 8D
´Â
!Hu$e$ $
rE^ U0=U3
/?1
wx
!Hu$e$(
çI!™áÖBe
çÂ
:8C
IJƒ¢ËÃÄ
$
´áM2UNOPKL
UsƒŸï2e
$
fgŸUâde
(
Z[Ä
!8AD
nÍ{©Ast./2ÃD
$
q8
(
8
!
!™áÖBQ
:8C
IJM2UNOPKLÃj¢NÖ?ƒRS
!
(
Ps-$#z(
BK_VO!ITO-SJ.T.76/KS@?1O.1 VOTSNO1S@?-WVK@TW1-S?.1 ?1 :8C5?1UW-OU -M@.1?-MOK@STK?VW@O?1 @KSJ!
(
Ps-$#z(
©Ä U&
=
I
=/?1
ŸUâdeÝÃÄ
E^ 8D=//[R
oE^ U0=U3
/K7
=//[R/J
r
rE^ U0=U3
/?1
=//[R/J
r

&$# s# &$,$* s(,# # (4,$ s%)&, r& #$,)* s%(),*(
¾§!™áÖB
)(% s) )4,) s%,(* # &),)) s&#$,#* r& #&#,&4 s%#,&
:8C )*
s*$

4e$4
s#e$

&(e%$
s)*e&

r) #e*
s)%#e&$

!™áÖBÂÍ{
o:8C )%
s*%
)
)e)%
s%e#*
*
# #%e*4
s)4#e#
)
r& &&e%
s#$#e$)
*
!™áÖBxÍ{
o:8C ))
s
)
*%e($
s)e)
)
($e% s%%e$$ r& )%)e**
s#%#e4
)
©Ä
ŸUâdeÝÃÄ
83D=//[R 93D=//[R 8AD=//[R

),)# s,* 4),4% s&,* %*,&) s&,*(
¾§!™áÖB
)),%# s(,*) 4),*) s$,(# %*,() s&,##
:8C *e44
se%

($e(*
s%e4

#)e$4 s)e4$
!™áÖBÂÍ{
o:8C *&e
se4
*
4e*)
s#e*$
*
%&e$% s(e#
!™áÖBxÍ{
o:8C 4e%4
s#e&%
)
(#e#& s#e4 #e() s$e*(
!!
€
#
…Q²©þs

Hu$e$)
…Žb©þs
*
Hu$e$$
)
Hu$e$!
8
*
(
& &^!
!™áÖBQ
:8C
IJM2UNOPKLm
Uz{
=
y)s-”ŸUâz{
=
y)s-ƒRS
!
¾§!™áÖB©…Q²©st
$
mUz{
=
y)s
-”ŸUâz{
=
y)s-./2ÃD
( :8C
©
mUz{
=
y)s-”ŸUâz{
=
y)s-…Q²
©þs4.´Â
!Hu$e$$
ÝÀ!™áÖB
!$$$
$ /R/\R
r

©mUz{
=
y)s-
!Hu$e$
Ý
ŸUâz{
=
y)s-
!Hu$e$
¿Êw
(
çI!
™áÖBeÖC}
:8C
IJƒKLUsÂY
$
q
8
*(
& )^!
ʼn©a
[I
eïÂÃ
!
¾§!™áÖB
©ÝQ²©þs
$
KLUs©a\qDŒ
$
ʼnƒ„
¿Ø
$
c
( :8C
©UstuWȬ:
$
èŠ#ÑÒ
ÍD
$
KѪUstu™
$
UsÑÒÉ@Ý|ÑÃ$
X[®)
$
Eq„{^ŒUs©aÑÒ
$
ʼnƒ„Ö
!
$
&cØÙ
(
!™áÖB®Ý,Í{ƒ´Â
$
U
stu™Nñ×IDáfg
$
”à!™áÖB
!$$ /R/\R
r

fg•ÁtØ4.
$
‡\q#Ñ
ÒÍD
%
UsÑÒÉ@”|ÑÃ$X[D4.f
g
$
ʼnƒ„Ö
:$
!cØÙ
(
çI!™áÖBe
ÖÌ&
:8C
IJM2UOKLUsƒ„”Uâ

$
qg
*
Ý8
)(
/)%&/
t
)4
Çt
)
v
*$&
o
*
p
!!!!!! ! ! ! ! ! !!!! ! ! ! !
.^Ve)4$:JJWO!)
GO_@WK@6$ *$&
8*!
!™áÖBQ
:8C
IJM2UNOPKLy)ÝU)z{ƒRS
!
(
Ps-$#z(
BK_VO*!ITO-S.T.76/KS@?1O.1 _.U6+O?RMSK1U MOK@S+O?RMS?1 :8C5?1UW-OU MOK@STK?VW@O@KSJ!
(
Ps-$#z(
©Ä
ã:y)
=R
¡²y)
=R
mUz{
=R
ŸUâz{
=R
mUz{
=
¡²y)
=R/!$$ R
r
ŸUâz{
=
¡²y)
=R/!$$ R
r

*)$, s*,# )&,# s)$,% ,$& s$,$( $,#4 s$,$ $,)) s$,$* $,** s$,$*
¾§!™áÖB
*), s*,) )**,4 s)*,) ,$# s$,$( $,%* s$,$% $,)) s$,$) $,** s$,$*
:8C *)$e# s$e& *(%e(
s*)e&

e&4
s$e$

e$$
s$e$#

$e
s$e$*

$e)&
s$e$*

!™áÖBÂÍ{
o:8C *)#e s$e# *4e( se4 e)(
s$e$4
)
$e4)
s$e$#
)
$e&%
s$e$
*
$e)*
s$e$*
*
!™áÖBxÍ{
o:8C *)*e( s)e) )$$e s)e4 e)4
s$e$%
)
$e4# s$e$% $e&(
s$e$*
*
$e)*
s$e$*
*
3,
Q²©
)Xe
¾§!™áÖB©
)©
)Ae
!™áÖBÂÍ
{
o:8C
©
)Ie
!™áÖBxÍ{
o:8C
©
(
g
*!
!™áÖBQ
:8C
IJM2UNOPKLUs©a
­zƒRS
![I$t*$$
G?Re*!ITO-S.T.76/KS@?1O.1 -K@U?K-M?JS.]KSM.V.R?-KV-MK1ROJ
.T:8C5?1UW-OU -M@.1?-MOK@STK?VW@O?1 @KSJ![I$t*$$
& $^!
!™áÖBQ
:8C
IJM2UNOPKLÃ
‹
3A93
ƒRS
!
¾§!™áÖB©…Q²©Ã
‹
3A93
./2ÃD
(
…Q²©þs
$:8C
©Ã
‹
3A93
@{4.OÂ
!Hu$e$(
!™áÖB
!$$$$ /R/\R
r

©Ã‹
3A93
@{4.wx
!Hu$e$(
çI!™áÖBC}
:8C
IJƒKL
Uâ)
$
…wxË
3A93
@{Dð
$
qg
)(
& \^!
!™áÖBQ
:8C
IJM2UNOPKLU
s©a
D>9B
Ý
AA3[*
8¦ƒRS
!POJSO@1
_V.S?1R
x#_,.I
$
…Q²©st
$
¾§!™á
ÖB©Us©a
D>9B
Ý
AA3[*
\q./2Ã
D
$
F
:8C
©
D>9B
8¦4.´6
!Hu$e$$
AA3[*
ƒ8¦4.wx
!Hu$e$(
ÝÀ!™á
ÖB
!$$$$ /R/\R
r

©
D>9B
8¦…
:8C
©
./2ÃD
$
F
AA3[*
ƒ8¦4.´­
!$$ /R/
\R
r
©
Hu$e$$$ /R/\R
r
©
Hu$e$(
çI!
™áÖBe´6
:8C
IJUs©a
AA3[*
ƒ8
¦
$
‡QOƒ
D>9B
8¦RS
$
qg
&$(
)!
–ð
!™áÖB÷á$Ç$Ùò¿B[½
$
~D
Qÿr2UsÃƒ„
$
fgM2UNOPKLU
sÑÒde”Ãj¢N
$
ûœUâ)¤!./ƒ
UÃ$¦§
,5)$ -
$3A93
÷ƒ(ô˜Y½UÃ
$9ÅÖËÆHƒÉ#ÆH
$
Ë
3A93
ƒoñ…
M2UNOPÝþð
$
wxË
3A93
@{Qf
gM2UNOPDß
,5%-
(
é~»©Yv‹Œc
Š
$
á$Ç$ƒQ½Ùò¿BáÖBQDEF
ØGHkKLr2UsÃƒ„~D…†¦§
ö‘}…
3A93
R¸BPDð
,(-
(
Øl
$
鋌
’½ä•–ß!™áÖBQ
:8C
IJKLM2
UNOPƒC}¦§ƒ‘}÷؅
3A93

BPDð
(
‹Œ_,84
$
!™áÖBQ
:8C
I
JƒKLM2UNOP~D…†¦§
$
efgŸ
UâdeÝ_
$
ö¦§‘}…¹|
3A93

BPDð
(
!!-B1 :
÷UstuÂìD2ƒ¹ÀXü
$
÷Us
ƒ„‰ŠàìDƒÃ‹~.¿
$
åUsÑ҃„Q
$
eK{:ˆìÃ
,*-
(
¢¿‹Œ_,84
$:8C
kr2UsÃKLË
-B1 :
oñOÂ
,*-
(
é
‹Œ_,84
$
!™áÖB
!$$$$ /R/\R
r

e
±./wx
:8C
ákË
-B1 :
ƒÈ±
$
çI!™á
ÖBQUsƒ„~D…†¦§
( /R/\R
r
DEF
ØGH£Ý,
% U$
eÖ./wxUeŸïÝZ[
de
$
鏐‹Œ84
$:8C
eÖ4.wxKL
[>$
/&%&/
t
)4
Çt
)
v
*$&
o
*
p
!!!!!! ! ! ! ! ! !!!! ! ! ! !
.^Ve)4$:JJWO!)
GO_@WK@6$ *$&
!!
8
)!
!™áÖBQ
:8C
IJM2UNOPKLUs©a­z›cƒRS
!#z
BK_VO)!ITO-S.T.76/KS@?1O.1 SMOUOR@OO.TM?JS.]KSM.V.R?-KV-MK1ROJ?1 /6.-K@U?KVS?JJWOJ?1 :8C5?1UW-OU MOK@STK?VW@O@KSJ!#z
©Ä
Ustu™Nñ #ÑÒÍDNñ UsÑÒÈÉNñ |ÑÃ$X[Nñ
r o
&
r o
&
r o
&
r o
&

$ $ $ $ $ $ $ $ $ * 4 $ $
¾§!™áÖB
$ $ $ 4 * $ $ % & $ $ * % * $
:8C $ $ & % $ $ $ $ $ $ $ 4
!™áÖBÂÍ{
o:8C $ * 4 $ $ $ $ $ % ) $
!™áÖBxÍ{
o:8C $ * & * 4 $ $ $ $ $ $ ( ) $
!!
€
#
.³“ÊUs©aƒ„›c
#$
c
$! r
\qDŒ
)
c
$! o

)
!c
$!
&


)
&c
$!



(
g
)!
!™áÖBQ
:8C
IJM2UNOPKLË
3A93
ƒRS
!
(
Ps-$#z(
G?Re)!ITO-S.T.76/KS@?1O.1 VONOV.TJO@W/3A93?1 :8C5?15
UW-OU -M@.1?-MOK@STK?VW@O?1 @KSJ!
(
Ps-$#z(
g
&!
!™áÖBQ
:8C
IJƒM2UNOPKLUs©
a
D>9B
8¦ƒRS
!
(
Ps-$#z%
G?Re&!ITO-SJ.T.76/KS@?1O.1 O7]@OJJ?.1 .TD>9B ?1 MOK@SJ
T@./:8C5?1UW-OU MOK@STK?VW@O@KSJ!
(
Ps-$#z%
83D$93D$ E^ 8D
Ý
oE^ U0=U3
/K7
”OÂ
rE^ U0=
U3
/?1
$
…9D“ga½k
,4-
(
!™áÖB
!$$$$
/R/\R
r

e—\Nñƒfg
:8C
ákƒnDŒ
Ãj¢N¨~
$
çI!™áÖBQM2UNOP
KLƒUde~D…†¦§
(

$:8C
©KLm
!!
…Q²©þs

Hu$e$)
…Žb©þs
*
Hu$e$$
)
Hu$e$(
g
!
!™áÖBQ
:8C
IJƒM2UNOPKLUs©
a
AA3[*
8¦ƒRS
!
(
Ps-$#z#
G?Re!ITO-SJ.T.76/KS@?1O.1 O7]@OJJ?.1 .TAA3[* ?1 MOK@SJ
T@./:8C5?1UW-OU MOK@STK?VW@O@KSJ!
(
Ps-$#z#
Uz{
=
y)s-”ŸUâz{
=
y)s-…Q²©
þs¿./´Â
)
Usʼn©aÝÒ84
$:8C
©U
s©aƒ„®)
$
ÖUs©atu™ØÙ
$
…“ga
Â_,½k
,4-
(
!™áÖB
!$$$$ /R/\R
r

e
./wxM2UNOPKLmUz{…y)ƒs-
”ŸUâz{…y)ƒs-
)
4.Ì&Us©aƒ
„Nñ
$
aö÷Ì&
:8C
ákM2UNOPKLU
s©atu™‘Ø4.
$
FQ#ÑÒÍD
%
UsÑÒ
Èɔ|ÑÃ$X[4.fg
(
çI!™áÖB
efgUNOPKLUâ)ÝUsƒ„
(
3A93
÷½Q8@2½!™¨ˆ]
!;C8
C}
Í
$
e±wx8@2½!™¨È±
(
‹Œ84
$
M2
UNOP·àË
3A93
ȱ4.´Â
$
y8Ž­
3A93
e´6UÃ$äZƒ«Ë
,5#-
(
¢¿8
4
$:8C
IJƒr2UsÃKLË
3A93
@{
/%&/
t
)4
Çt
)
v
*$&
o
*
p
!!!!!! ! ! ! ! ! !!!! ! ! ! !
.^Ve)4$:JJWO!)
GO_@WK@6$ *$&
./´Â
,(-
(
鏐_,84
$:8C
IJM2UN
OPKLË
3A93
@{t^ŒKL4.´Â
$
Ý
À!™áÖB
!$$$$ /R/\R
r

e4.wxË
3A93
ȱ
(
çI!™áÖBC}
:8C
IJKLM
2UNOP¦§…wxË
3A93
ȱDð
(
3A93
Ÿy8÷Ö
65
GÛø:l6Øø—…
y
$
ŸXü°l6ø—œ|]
!D>9B
¦§Êñ
™
$
ÏXüȑ]ȑš
)
öR¸Ùò÷”2ø—
°l62øÙȑ]
!AA3[
›‘Ø¥l6Ý2ø
Ù
( AA3[
÷½QÒìXü]
$
¼Ÿ
*
J9b
$
AA3[
Ý
AA3[*$
ö$
AA3[*
­¼Ÿ˜Ö8Vb
½!™¨ˆ]
!O;C8
8¦Øك©a$
$
üUs©
aÝÃ$!
,5#$)-
(
鏐_,84
$:8C
eIJU
s©a
D>9B
8¦´­
$
”wxUs©a$
AA3[*
ƒ8¦
(
!™áÖB
!$$$$ /R/\R
r

e
4.´6
AA3[*
ƒ8¦
$
‡QOƒ
D>9B

RS
(
çI
$
!™áÖBBŽðÆ
:8C
IJƒU
s©a$wxƒ
AA3[*$
F̄
3A93
@{
(
òØáÞ
$
!™áÖBQ
:8C
IJKLM2U
NOP~DC}¦§
$
ö‘}…´6Us©a
AA3[*
ƒ8¦
$
’FwxË
3A93
ȱDð
(
!™áÖB÷½Q,‰¦§=ðƒ,¿
$
³
´§˜]¤Ób\#
%
\tu™
$
QM2FeÅ
·àeƒZFAztu™
$
ö—•èuc&
x
,&5-
(
!™áÖB[~DC}ÉÊÑÒ´Ó
$
&’ÉÊÑÒno
$
C}ÉÊÃ$š!¦§
)
…O§Ù
%
±òhH
%
C¦Ý

ü0ýþ!ÿ
ÉÊ,¿¥ˆ¿§e´á¤µ
$
”wxˆ™¤ƒ
,¦§
,#-
(
鏐‹Œ_,’½ä45ß!™
áÖBQKLM2UNOPƒ…†¦§…‘}
$
½†Ñ
$
؃ã!™áÖB§˜]¤M2UNO
Pç…ߏ×
$
Q½†Ñ
$
û؋Œ!™á
ÖB÷ØQÿÉÊ,ákUeƒ„~D…†¦
§ç…ß)òSÚ
(

q‚ƒ
#
, -!
øJ½
e
!™áÖBQUÃ$9Ń,‰¦§”ö‘}‹
Œ’“
,Y-e
$%,%
$*$*$ *!) # $e
, * -![W 8 B$BK1RQ$ 8MO1 QG$OSKVeD@.SO-S?NOOTO-S.T.76/KS@?1O
.1 -M@.1?-@KSMOK@STK?VW@O,Y-eYDM6J?.V8-?$*$$# !#
)#)e
, ) -![.1R5E?8$ EO?E$ XK.5GO1RQ$OSKVeK1U W1UO@V6?1R/O-MK1?J/J.T.76/KS@?1OKRK?1JS?J-MO/?-/6.5
-K@U?KV?10W@?OJ.T@KSJ,Y-eDM6S.SMO@>OJ$*$$($ **!%# 4(e
, & -!>.RO@^ EeBMOMOK@STK?VW@OO]?UO/?-,Y-e:1SYI1N?@.1 >OJ
DW_V?-[OKVSM$*$$$%!&#($%e
, -!8?_KVE$ 3RK@+KV8 <$ [./ODA$ OSKVeBMO@.VO.TKJ6//OS@?-
U?/OSM6VK@R?1?1O!3A93 ?1 O1U.SMOV?KVU6JTW1-S?.1 K1U -K@U?.5
NKJ-WVK@U?JOKJO,Y-eON$*$$$#!*#(*e
, # -!X.RO@>[$ 8WV?NK1 E9$ 8-M+OUMOV/I$ OSKVeDVKJ/KKJ6/5
/OS@?-U?/OSM6VK@R?1?1OK1U ?1-?UO1-O.T-K@U?.NKJ-WVK@U?JOKJO
K1U UOKSM ?1 SMO-.//W1?S6,Y-e, % -![JW ?1O]@OU?-SJ-V?1?-KV.WS-./OJ?1 ?J-MO/?--M@.1?-MOK@STK?VW@O
,Y-e3SMO@.J-VO@.J?Je*$*$**!*#$&e
, ( -!E?L$PK1RL$HW.Q$OSKVe>ORWVKS?.1 .TO1U.SMOV?KV1?S@?-.75
?UOJ61SMKJOK1U KJ6//OS@?-U?/OSM6VK@R?1?1O_6/KS@?1OKSO1W5
KSOJ?J.]@.SO@O1.V5?1UW-OU K-WSO/6.-K@U?KV?10W@6?1 @KSJ,Y-eY
DMK@/DMK@/K-.V$ *$*$#&!(#$%e
, 4 -!d@O1O\ D$ d/O-.NKY$ dW-O@.NKA$ OSKVe:J.]@.SO@O1.V5?1UW-OU
MOK@STK?VW@O?1 SMO@KS?JKJJ.-?KSOU +?SM 1?S@?-.7?UO5UO]O1UO1S
TW1-S?.1KVKVSO@KS?.1J.T-K@U?K-TW1-S?.1 ,Y-eIW@Y[OK@SGK?V$
*$$4$ !*# &$e
,$-!XO10K/?1 :Y$ YKV?VYI$ BK1 EX$ OSKVe:J.]@.SO@O1.V5?1UW-OU
/6.-K@U?KVT?_@.J?J?1 @OVKS?.1 S./6.-6SO1O-@.J?J,Y-eOJ$
4(4$#!)##%e
,-!
!)
$
¹U
$
²§¨
$
!
e
!™áÖBQKLaË_˜Ic
r2Usµqƒ…†¦§”‘}
,Y-e
$%†Í-.
$
*$*$(!&$&e
,*-!CaX@?O1 DY$ 8/?SM AI$ d1O-MSOVBY$ OSKVe?JKJO1J?S?NO$ J]O-?T?-_?./K@\O@.T-K@U?K-?10W@6?1 VK_.@KS.@6
K1?/KVJ,Y-eEK_ 31?/$*$$#$&$!*#)e
,)-!d.1?JM?[$ 86U.+d$<..\OYDeA?/OSM6VK@R?1?1OU?/OSM6K/?15
.M6U@.VKJO]@./.SOJO1U.SMOV?KV@O]K?@KTSO@NKJ-WVK@?10W@6,Y-eY
3/<.V,&-!
¬F*
$
—]Ô
e
!™áÖB
!
áÖH

]¤M2Ób\#
%
\tu™ƒ—‘…³´
,Y-e
Jù,
$*$$%$4!#e
,-!
¿©ª
$
•««
$
Åà
$
!
e
!™áÖBQM2FeÅ·à
Ë
99D54
Ý
B:9D5
ƒRS
,Y-e
M.QBKa
$
*$$($*4!#(&e
,#-!
é¬à
$
ïËg
$
ÐH±
$
!
e
áÖB…!™áÖBÿÉʦ
§”ö‘}ƒ‹Œ’“
,Y-e
$,,…³´,‰
$*$*$*)
!)#)#4e
/#%&/
t
)4
Çt
)
v
*$&
o
*
p
!!!!!! ! ! ! ! ! !!!! ! ! ! !
.^Ve)4$:JJWO!)
GO_@WK@6$ *$&
ME@B?SB.P??K?SB@K@ND,-BE.A?@ASCE@A.SC?-EBK-./GE?-AF4><4
,?B-J@/.I,L-BCU-D .A.I@LE@B?E?A@/+.AFGS?FSCE@A.SC?-EBK-./GE?.AE-BI
P3;HQK1R

$ L` QO5MWK
*
$ L:C;H3?5c?1
*
$ Q` 3;QK51?

$ b[I;HD?1R

$ 93D?1R
*
$ A3:HW?5U.1R
)
$ L` F?1R5_?1
*
!
!eF&03($4H/(+$)$1=$ ;,#1P, ?&%,+)I#,7&-,3=$ ],#+/*# %$$$&$ 5/,#)
*eF&03($45%,$)$1=$ !&#&)M$-0,3)$4;,#1P, ?&%,+)I#,7&-,3=$ ],#+/*# %$$$&$ 5/,#)
)eF&03($4H/(+&*3,+).#1,#&&,#1$ 6+/$$)$45/&(,+)#% ?3&,)-.#1,#&&,#1$ D,),I#,7&-,3=$ D,),#$$ 5/,#
,4JIBE-SB-!6J[?SB.P?# B.?1NOJS?RKSOSMO]@.SO-S?NOOTO-SJ.T.76/KS@?1O.1 -M@.1?-MOK@STK?VW@O?1UW-OU _6?J.]@.SO@O1.V
!:8C K1U S.._JO@NO?SJOTO-SJ.1 3A93/OSK_.V?J/]KSM+K6?1 :8C5?1UW-OU -M@.1?-MOK@STK?VW@O?1 @KSJeAK+VO6@KSJ+O@OR?NO1 .76/KS@?1O!$$$$ /R/\R
r
.@KV6T.@& UK6Je[OK@STK?VW@O+KJ?1UW-OU ?1 @KSJ_6JW_-WSK1O.WJ?10O-S?.1
.T?J.]@.SO@O1.V! /R/\R
r
/U
r
KSSMO(
SM
UK6T.@ +OO\e8O@W/]K@K/OSO@J$ MKO/.U61K/?-]K@K/OSO@J$ [OK@S+O?RMS$ K1U M?J5
S.]KSM.V.R?-KVNK@?K_VOJ+O@OK1KV6JOUeI7]@OJJ?.1 .T]@.SO?1 VONOVJ+O@O/OKJW@OU _6POJSO@1 _V.Se8?IG/B# C76/KS@?1O!$$$$ /R
/\R
r
J?R1?T?-K1SV6KSO1WKSOU JO@W/-.1SO1S.T-B1 :$ ?/]@.NOU VOTSNO1S@?-VOJ6JS.V?-K1U U?KJS.V?-TW1-S?.1 K1U VOTSNO1S@?-WVK@@O5
/.UOV?1R$ @OUW-OU SMO:8C5?1UW-OU /6.-K@U?KV]KSM.V.R?-KV-MK1ROJ-./]K@OU +?SM :8CR@.W]e:1 KUU?S?.1$ .76/KS@?1O!$$$$ /R/
\R
r
J?R1?T?-K1SV6@OUW-OU JO@W/VONOV.T3A93!Hu$e$$ 1.@/KV?ZOSMO@OUW-OU U?/OSM6VK@R?1?1OU?/OSM6VK/?1.M6U@.VKJO*
!AA3[* O7]@OJJ?.1 !Hu$e$$ _WSMKU 1.OTO-S.1 SMO?J.]@.SO@O1.V5?1UW-OU W]@ORWVKSOU ]@.SO?1 K@R?1?1O/OSM6VS@K1JTO@KJOJ O75
]@OJJ?.1e0@AS/GI.@A#C76/KS@?1O-.WVU K/OV?.@KSOSMOO7]O@?/O1SKVNO1S@?-WVK@@O/.UOV?1R?1 :8C5?1UW-OU -M@.1?-MOK@STK?VW@O?1 @KSJ
K1U SMO/O-MK1?J/?1N.VNOU ?1 @OUW-?1RJO@W/-.1SO1S.T3A93K1U ?1-@OKJOU AA3[* O7]@OJJ?.1e
,W?D U@EFI-!.76/KS@?1O) ?J.]@.SO@O1.V) -M@.1?-MOK@STK?VW@O) 3A93) D>9B) AA3[*
F@.#(_)\`OS[S,,()(&

„…-0
!
–——
#
/%%&/
t
)4
Çt
)
v
*$&
o
*
p
!!!!!! ! ! ! ! ! !!!! ! ! ! !
.^Ve)4$:JJWO!)
GO_@WK@6$ *$&