免费文献传递   相关文献

Characteristics of changes in urinary NGAL, KIM-1 and IL-18 in Phytolaccae Radix-induced renal injury in rats and significance of combined detection

尿液NGAL,KIM-1,IL-18在商陆所致的大鼠肾损伤中的变化特征及其联合检测的意义



全 文 :K°
=YC7!ZV;06!V7064
]0±²²[ª«
•³´r[D\°]Gª¸Äµ%[@¶
TÒN
!
ÓÔÔ
!
ÕÖI
!
!
7Ë×

áj]_}B ŒÞ@›œmn] 
!
áj
K36K35#
$
x*
%(

.
T‡•³´À¥ÌrœlÂÃ.qGj‰{YI|½u
$=YC7%#
•³´Äj
06$ZV;06%#
u}—
064
$V7064%
]0±²²[ª«•³´r[D\°]Gª¸Äµ%[@¶

© 
. ^18]-F
ª«â…6ê0±‡~°=
#
nÛ·
$
ã
Ç
S3!K3 E/IE
<6
/:
<6
%
ÙÑA“Ù
!
S°±Ã
52 :
{
P! 6S! K6! K4! 52! SK :
ž¯Q
N
K[
!
>6ÃÎHÖ¥

ã\6Œ
ßµ%Qó9½u
$)H%#
u½u
$C7b%#
K—’
$b[=%#
QYÅ
$A>%!

a)H! aC7b

!
G¸¹ÁG”
$/7V?C%
µ%K
°
=YC7! ZV;06! V7064
<

Iw
N
2w«èé•XL¥Ù¬}í]¿D
>DA
^o^_¿Qó
N
K°!ÀG¸Äµ%[^
oTU

ª“
.
ܕª«
S3! K3 E/IE
<6
0±‡~°
52 :
*²•³´
!
•6,_tÂÃDœ
#
½u,âê‚&L¥¼R
!
ï
j–Ø6³´*a

iA“Ùj^
!
¿Û·Ù
b[=!A>!a)H
™s«|åÓ
!
{
K6
8
aC7b
v¢3=m<°ØÜÇé
=YC7!
ZV;06!V7064
{
P
8Ԙ™3=
!
{
6S
8´¿Û·ÙŒèv¢œCE
$%g3e36%!
ïj–=Û·Ù
ZV;06
}èv¢D
>DA
6Œ„F[^oTUê
3e4SL! 3e45P! 3e4L5$%g3e36%!
ÕÕ=
b[=!A>
‡

f¸Äµ%[TUk
3eUSP
ª«
.
K
°
=YC7! V7064! ZV;06
g]|Ô­_™%Jµ½•³´[€ã
#
€N
!
xè_=[ÝǜÑØI°Eœ

ª¸Äµ%Sg
µ=µ¨ég

$
yz{
%(=YC7&ZV;06&V7064&
¸Äµ%
&

&>DA
$
|AY
%(K36K3262364
$
}~ 4 c
% (
­ æ i - s © ƒ „ € N . =
$ UP5 %
u v
$K33UAb2KK43P %&
­ æ
)
i ª ‹ Ç a Ü
*
ø ù i ª ¬ u
$K33UWX3U23K033K%&
_*SÄI™P~uv
$K363O^ 53%
$
v-€
%(
!
JR
!
67
!
ȃ„5
!
¶7ã8
!
²ØrNj
ÇGª×Oœ݃„
!)*+.$3K6%265KKSPK!/0%-1+. TE]6ULUQT-0
9&&e#&%e#
$
-€‚
%(
õ|ï
!
¶7ƒ„ã
!)*+.$3K6%265K5325!/0%-1+.+1T0
1`*1PK2QT-9&&e#&%e#
((
Ç̜•³´@æçY*K[|ª©•
X¬L

ûѶ©[€RÇÌA•X[ÏBE
›
!
™÷;)*N‰?

TS꩖
#
¤Ý
#
°E[•³´ãÌÀ¥ÌAæ睐
#
=>ÑÇ
ÌϜ™%
#
Ýøèäi&@¶

vh
!
]A
rDz²[•³´j‰ƒ„r
!
ãG•³´À¥
̵%[V֝Y–¹g

¤ƒ„µ›rÇ0
±
!
±ª«‡~°
!
6Œ•³´K°À¥Ì[
D!
0Ä%ä•ßg!Àµ%ÑÙ¬}í]è
é
!
Ý¿À¥Ì[µ¨égGª¸Äµ%]0
±•ÏœÝr[Ý_

–êrǕϜ[
æçhݵp‹™/
!
êæ畳´[g=µ
p‘’

!
ÁÂ
!Y!
ÊÌ
(
Ãë
1^8]-F
ª«
$643 jK3% E
Ð
634
Ü
!
öã¿[
!
o_*->
0
‘⧨ÊÌè—(µp
!
H*Æf
?AXZ$
Ç
%K3340336L!
óõ¸

_*r<Ç
ª]§¨ÊÌrà0ùÑ,¥
!K3 iK2 l
ÄÌ
!6K 9N6K
9
.|I“ó–
!
ÊÌ*loQOѼ‡

!Y#
ÇÁ
(
ã0±
!
0±ø0±L
!
äQ–Ó
!
–Ó
‹ØzrǼsL÷è—(µp
!
Ãf
63663SL
‘“
K363
÷Ã
,
r­ÇÒ
-)
0±Z·%ԅ”
*
G
7«5Å
6(
!
%&0±ÇÁr0±Ø£ß[Y·6

KeU2 %E/E
<6
$
ãÇ
%!

,
r­ÇÒ
-
ÓÔ

Ç°ÜÝ
.
#ã0±¼s
6 IE!
a
2
ý·Ð½‡

U3 %1
©^
!
VÇ°|ò€úû¾
!
7€~ú
53 %1!
Mw¡›
!
H¯›°

ûYÐ~ú
K
5

Ä
>›°
!
]
L3 i43 l
<£Ø
233 %7!
Ô&
K E/%7
<6
[0±‡~°

æ›hÏaн‡ìز×<

!Y$
çÛ
(
ã\!Àµ%çÛ
.)H$7663K326%!
C7b$7663S3K6%!b[=>6 $A6K2%!>K $C6K2%!A>
>6$/6K4%!>K$/6KP%!
Œo¦¤<éæ睐Ü-
ñ~åÀãä

ª«
=YC7!ZV;06!V7064 /+V?C
çÛ¸
!
jl_
/66L5/
{
5P
ï{
K5
–
K36K
÷
6K
³
(((((( ( ( ( ( ( (((( ( ( ( (
B&+e5P!V88a*(K5
@*#*%d*F!K36K
*kêøãÌøùè—(
!
Ãf
K36666
!Y%
ßà
( -^]*F8KLU2$C+1-#*

%
=é°j|
Šß
&
I2üc,@J
$G9&]&0:1&:*-F-T:*]*#]*F!
H@C%
µ%à
&
¦¼
P343
OlÊã\6Œß
$
¦¤
JV0
)CAJV
—(ãä
%&bX26
»|vXw
!D7_;H[? @HPK
=6O¬¾(X#
AAV$
¦¤¶;Ñ;I]ñ~åÀ
ãä
%&)9*F%&;Z5
GÀß
$
w2_*ßàè—(
%
#
…”
#Y!

#
ÜÇÑÖ¥
(^18]-F
ª«§¨hQ\œ

6
ó
!
â…6ê0±=Û·Ù
#
0±nÛ·Ù
#
A“Ù
!

5L
Ü

6e±Ãܕ
K!6 E/%7
<6
0
±‡~°Ñ‡·Ð½‡
!K3
!
7/E
<6
!
:8ÜÇ
6
5
!

52 :!
ÆÇïj–
P :
3ÎèéÊÌ]ÜǖšGïj–[|Ÿ…ì
Gî?R´

6eÜÇ{
P!6S!K6!K4!52!SK
8
#¿Ù
4
ÜÊ̋ÑôF3
$
ïj–#[-Zè
L
ÜÊÌ
%!

L 9

!
ÊÌ]ôF3~1OY1
‡

:ÜÊÌ#KôF37MÊÓ~NžQ

¿
#[-¿Ù6e#
L
ÜÊÌ
!
‚4¾ÎH
!
#=†
•XMÊÙ¬L¥]µC

#Y#
9Óã\!Àµ%
(
¿7š-¿ÙÊÌ[Q
°
#
K°
2 333 F/%1
<6

62 %1
¾G#_ó
°
!
OlÊã\6Œßµ%Qó
)H!C7b!b[=!A>&

a)H!aC7b
è«K[|
<43 l
͍

#Y$
•³´À¥Ìµ%
(
’çÛ¸h.Ç
!
ž›
/7V?C
…”µ%¿7š-K°[¤r
=YC7!
ZV;06!V7064
[Z·

͍[¤µ%h
S l

!
û
KR+
!

5 333 F/%1
<6

62 %1
¾G#_
󛝵%

#Y%
•Ù¬}í]èé
(
A¿7š-¿Ù©•À
¤
!

63f
>ó;rùÔ
!
ÜÝ56Îs
!

J/
È|¾I]vXw«èé•Ù¬}í]D
V•XLD­6ê
2
‡¸
.)
O
*!
•Ù¬01
»9
&) j*!
«XE9
$
*DÀ][ÂÃDœJß
î
%&) h*!
«³´
$
*D_™[ÂÃDœJßî
!
LDs6Pœ
%&) hh*!
r³´
$
*D•6,J•
6¦01D!
LDs™Pœ
%&) hhh*!
i³´
$
*D.v[•6,J•6¦01D!
LDs‚

%
6e.E
3 iS
6

A{
P!6S
8¿Ù^•
À¤
!
#t¢à=Ù¬|
S l!Ke2f
Qü,b°
rùÔ
!
ÜÝ KÎs
!
ÌÈ|
!
sÖ2wèé•6
¦Ñ•6, X01

#Y&
ä.6Œ
(
ä.]6Œ\›
?H?? 64e3
ä.
&r

.·šÂ#
Fj(
¼½
!K
ٚ^_ž›
!
µ¨
!
…C?œ7
7?@
…”
#
…CY?7
@a*]s8
…”


‡¸šÂMÊRKO[Ƒ(µ¨
!

>-:1]
6Œ^_™ÙšL¥³´­[CE

ü;
7&E180
]1#
É*6Œ.P
=YC7hZV;06 hV7064
A¿[¤[
™%¢<_GÉ*…­
!>DA
^o.P>^_¿À
¥ÌG¸Äµ%™%¢<[^o«TU
#
|n,š
#
^oÓÀ
%g3e32
êCEèä.]@¶

$

$Y!
Qóã\!À
(b[=
ÜǾƒè3=×<°
|n

iA“Ùj^
!
=Û·Ù]h
5
7š-ƒ
è_3
!
ªr{
K6
8v¢œ3=
$%g3e36%!
{
K4
8˜™v¢œ|n
$%g3e32%!
ýØ{
52
8
&

·Ù{
6S
8;è3=ì,CE
!
{
K6
8´˜™«
|
!
{
K4!52
8Œèv¢œ|n
$%g3e36%
A>
ÜǾ<°œ|n

iA“Ùj^
!
=Û·
Ù_ê‰K
!
¿7š-Œèv¢CE
$%g3e32
J
%
g3e36%&
nÛ·ÙZ{
52
8èv¢D$%g
3e36%
fYZ۷ٚè|Ô[·é‰F

ïj
–0Â7
!
¿Û·Ù
b[=!A>
iA“ÙŒ,CE


6
¼
6(
0±‡~°Aª«Qó
b[=!A>
[vw
$
#
Fj(!1M4%
)-d+*6()9**`*#]&`H9T]&+-##-*>-:1.& F-]8*Fa%b[=-: A>1 :1`*F*]]1%*G&1]$
#
Fj(!1M4%

N:
b[=N%%&+/7
<6
A>N
!
%&+/7
<6
A“Ù nÛ·Ù =Û·Ù A“Ù nÛ·Ù =Û·Ù
P S3U j323 S35 j326 S5U j32L K633 j6L3 K323 j6K3
64P2 j645
6!5%
6S S55 j3LL S22 j3LU SP6 j32P K265 jK35 K5P2 j566
K344 jK53
K%
K6 SS3 j3S3 S53 j3L4
256 j3L2
K!S%
KS54 j6L3 KS65 j65L
6UP2 j66L
K!S%
K4 LK5 j355
26S j34P
K%
22S j3P4
6%
KPK2 j65U K2P2 jKP6
KKL5 j6PP
K!5%
52 256 j3S5
S56 j362
K%
23S j3S5
S%
K4L5 jK3P
KSL5 jK33
K%
K665 j665
K!S%
SK 263 j662 S43 j32L SK4 j3P6 K5P2 j323 KSP2 jKKK K233 j52L
((
?
.
iA“Ùj^
6%
%g3e32!
K%
%g3e36&
inÛ·Ùj^
5%
%g3e32!
S%
%g3e36$
d
6!K!
¼
K!5
Z
%
/K6L5/
{
5P
ï{
K5
–
K36K
÷
6K
³
(((((( ( ( ( ( ( (((( ( ( ( (
B&+e5P!V88a*(K5
@*#*%d*F!K36K
(()H
™è<°œ3=

iA“Ùj^
!
nÛ·_
ê‰K
!
{
P!K6!K4!52
8Œèv¢œ3=
$%g
3e36%!
ÆǾ,CE
&
=Û·Ù{
K6
8´˜™3=
!
{
52!SK
8ôèv¢œ3=
$%g3e36%
Dd
6
C7b
=Û·ÙiA“Ùj^<°«|åÓ
!
{
K4
8_A“ÙÑn۷ٌèv¢œ|n
$%g
3e36
J
%g3e32%
nÛ·µ%_™=A“Ù
!
Z{
P
8èv¢œCE
$%g3e36%
Dd
6
Ce)H& beC7b
d
6(
0±Aª«Qór
)HNC7b
[vw
$1M4%
,1Ee6()9**`*#]&`H9T]&+-##-*>-:1.& F-]8*Fa%)HNC7b1 :1`*F*]]1%*G&1]$1M4%
$Y#
K°ã\!À
(a)H.
¿Û·Ù]¿7š-<
°«|åÓ
!
iA“Ùj^
!
{
P!6S!52!SK
8Ώ
v¢œ|n
$%g3e32
J
%g3e36%
Dd
K
aC7b.
iA“Ùj^
!
nÛ·Ù{
K6!K4
8
#
=
Û·Ù{
K6!K4!52
8[èv¢œ3=
$%g3e32
J
%g3e36%
inÛ·Ùj^
!
=Û·Ù[
aC7b
]
{
K4!52
8ôèv¢3=
$%g3e36%
ïj–¾¿
Û·ÙiA“Ù,v¢CE

Dd
K
Ce

a)H& be

aC7b
d
K(
0±AK°
)HNC7b
[vw
$1M4%
,1EeK()9**`*#]&`H9T]&+-##-*>-:1.& F-]aF1-FT)HNC7b1 :1`*F*]]1%*G&1]$1M4%
$Y$
•³´À¥Ì
(
iA“Ùj^
!
¿Û·ÙÙK
°À¥Ì
=YC7!ZV;06!V7064
]{
P
8Ԙ™3
=
!
{
6S
8´Œèv¢œCE
$%g3e36%!
mD<°Ø{
52
8

ïj–=
#
nÛ·Ù¿µ%_}=
A“Ù
!
ìZ=Û·Ù
ZV;06
èv¢œCE
$%g
3e36%
ij\7š-nÛ·Ù^_
!
=Û·Ù{
6S
8
a=YC7!ZV;06!V7064!
{
K6
8
ZV;06!V7064
ô
èv¢œ3=
$%g3e32
J
%g3e36%

K
$Y%
L¥]
(
Iw
.
L¥ØI•6,ê‚


·Ù³´KR_©
!
{
6S
8´Ôè6Pœ•6,_
tÂÃDœßîÆW
!
{
K6
8´•6,,Ì~V*
D½u,â
!
Ø{
52
8Œè¼R

nÛ·Ù{
K6
/56L5/
{
5P
ï{
K5
–
K36K
÷
6K
³
(((((( ( ( ( ( ( (((( ( ( ( (
B&+e5P!V88a*(K5
@*#*%d*F!K36K
((
¼
K(
0±‡~°Aª«K°
a=YC7!ZV;06!V7064
[vw
$Fj(!1ML%
)-d+*K()9**`*#]&`H9T]&+-##-*>-:1.& F-]aF1-FTa=YC7!ZV;06! V7064 1 :1`*F*]]1%*G&1]$Fj(!1ML% E/7
<6

N: (
Ùe
a=YC7 ZV;06 V7064
P

6 54KeU5 jPSeK3 52e5S j6eS4 5UeP2 j6e56
nÛ·
6 SS6eS3 jS4e3P 5LeP5 j6eK6 S6e3L jKeSU
=Û·
6 SPLeL3 jU5eU2 5Le42 j6eSL 5UePL j6ePP
6S

P53eK6 j665e6K 6UeKP j6e46 6PeP3 j6ePP
nÛ·
6 S3Ue3L
j6SSeK3
K%
53ePK j5e5L
K%
K4eL2 j5eKS
K%
=Û·
6 KSPeK5
jUKe36
K!5%
SKe65 j4e55
K!5%
S3e54 j4e24
K!5%
K6

2ULe66 jLPe63 K4eLU j5e26 KLeP5 j5eSL
nÛ·
6 KLPeL3
j4Ue43
K%
S3e5P j6eUK
K%
54e53 j6e45
K%
=Û·
6 KUKeSK
j44e55
K%
SPePU j6e2L
K!S%
S2e4K j6e23
K!S%
K4

L45eS4 jSUeU5 SLe53 j5ePU 52e54 jKe2U
nÛ·
P43eLP
jPSe4U
6%
25e54 jLeU3
5UePU j5e4U
6%
=Û·
P6Le2U jL4eKU S4e6K jSeKP 5LeLS j5e3S
52

2SSeSK j6KPe4P 6PeL3 j6e43 6Le3U j6eP2
nÛ·
6 526e2P
j632eU3
K%
S4e5U j2eL3
K%
SLe22 j2e44
K%
=Û·
6 S5UeL5
jL6eUL
K%
23e54 jSe43
K%
S4eSU jSeL4
K%
SK

6 2PKe5P jU3eK2 54eK4 j6e45 52eU6 jKe55
nÛ·
6 222e22 jU3eUL S3e65 jKePU 5Pe6L j6eP5
=Û·
6 LS4e2K jLLeKL
SSeSP j6e5S
K!S%
5Pe2P j6e66
8´KR6Pœ•6,_tÂÃDœÆW
!
{
K4
8
´Z7*D•6,,âÑ6Pœ•tYšY»¼
!
Œ<°Ø{
52
8

{
SK
8¿Û·Ù³´;è
›«

Ì
>-:1]

!
=Û·Ù{
6S!K6!K4!52!SK
8
!
nÛ·Ù{
K4!52
8[³´­_A“ÙŒè
v¢œCE

YZ۷ٚè|Ô[·é‰F

D
¼
5!
d
5
((
2w
.
]_©[
K
7š-
!
iA“Ùj^
!
=
#
nÛ·ÙÊ̕٬Xè01ŒèE9D!
*D
•6,ÂÃØ6,°XÊbÆW
!
•6,_tÂÃ
×~è{g
!
SËYI³
!
ècÏ
&
=Û·ÙÂÃ
à01ƒ›e

Dd
S
$Y&
À¥ÌÙÄ6Œ
(
¿À¥ÌG¸Äµ%ÙÄ
[
>DA
^oG6Œ0•û«
!

S#
d
2 iL
H
|À¥Ì
=YC7!ZV;06!V7064
¼RK_=[µ¨é
g
!C[A
6eê
3e4SL!3e45P!3e4L5 $%g3e36%
f
b[=
Ñ
A>
[^oTUŒ6
3e2
.P&
7&E18]1#
É*…­ê
. %M6N 6 h
*
<$ <62e24U h3e36KW
6
h3eSU4W
K
<3eS5KW
5
%
(
ij\[H|À¥
Ìj^
!
¸Äµ%ÙÄ
a=YC7hZV;06 hV7064
[^
o«TU
$C[A3eUSP%
.vfª

mi
b[=
Ñ
A>
j^
!
ÙÄ[µ¨égô読µ=
!
èv¢œC
E
$%g3e36%
¼
5(
0±²²[ª«•XL¥³´­6¸G
>-:1]

$1ML%
)-d+*5()9*8-%G+*Ra-]1]T-: >-:1]C-+T8181 G-]9&+&E1#-+
F-I &`F-]I1:*T1$aFT1:a#*: dTH9T]&+-##-*>-:1.$1ML%

N:
Ùe
< j h hh hhh >1
P

( L 3 3 3 3 35L6 6
nÛ·
S K 3 3 3 32KP 4
=Û·
5 5 3 3 3 3L66 6
6S

( L 3 3 3 3 3KPP 4
nÛ·
5 5 3 3 3 3233 3
=Û·
6 5 K 3 3
3PKK K
6%
K6

( L 3 3 3 3 3K23 3
nÛ·
5 6 K 3 3 3SPL U
=Û·
3 6 S 6 3
3PP5 6
K!5%
K4

( L 3 3 3 3 36US S
nÛ·
6 5 K 3 3
32LS 4
K%
=Û·
3 K 5 6 3
3PS3 P
K%
52

( L 3 3 3 3 36US S
nÛ·
6 5 6 6 3
32KP 4
K%
=Û·
3 3 5 5 3
3PPP 4
K!5%
SK

( L 3 3 3 3 3KKK K
nÛ·
K 5 6 3 3 32SL 5
=Û·
3 S K 3 3
3P56 2
K%
%
‡,
rÇ0±F0±LÉÌ0±
%26!.-++- -+01(-
>&.de
ÑÐe0±
%e-54,0+-1- 7e
[eåë

i
/S6L5/
{
5P
ï{
K5
–
K36K
÷
6K
³
(((((( ( ( ( ( ( (((( ( ( ( (
B&+e5P!V88a*(K5
@*#*%d*F!K36K
((
Ce
A“Ù
&be
nÛ·
6S :&Ae
=Û·
6S :!
_tÂÃÆW
&@e

·
K6 :!
_tÂÃDœ
& /e
=Û·
K6 :!
•6,,â
& ,e
nÛ·
K4
:!
šY»¼& Ye
=Û·
K4 :!
•6,,â
& Je
nÛ·
52 :!
Õ^
6,,â
& Ve
=Û·
52 :!
•6,ßî

d
5(
0±‡~°Aª«•XÙ¬[vw
$
Iw
!rK33%
,1Ee5()9**`*#]&`H9T]&+-##-*>-:1.& F-]I1:*T]188a*1
:1`*F*]]1%*G&1]$dT+1E9]%1#F&8#&G*!rK33%
Ce
A“Ù
& be
0±Ù
!
XÊbÆW
& Ae
0±Ù
!
×{g
!


d
S(
0±‡~°Aª«•XÙ¬[vw
$
2w
%
,1EeS()9**`*#]&`H9T]&+-##-*>-:1.& F-]I1:*T]188a*1
:1`*F*]]1%*G&1]$dT*+*#]F& %1#F&8#&G*%
¼
S(
0±²²[ª«•³´À¥Ì
>DA
^o‘(
)-d+*S()9*>DA#aFk*G-F-%*]*F8&`%-FI*F81 F-]F*-+10
$aFT1:a#*: dTH9T]&+-##-*>-:1.
À¥Ì
^o
TU
À+
-C
%
U2f
|n,š
« _
b[= 3SLL 332U 32S4 3526 3246
A> 3K5L 33SP 3333 36SS 35KU
)H 3LS6 3323 336K 32S5 3PS3
C7b 3SPU 33L3 3P3P 35L6 32UP
a)H 3K4S 33L2 3333 362L 3S6K
aC7b 3SUL 332U 3US3 3546 3L66
a=YC7 34SL 3323 3333 3PSU 3US5
ZV;06 345P 33S4 3333 3PS5 3U56
V7064 34L5 33S3 3333 3P42 3US6
( a=YC7 h
ZV;06 hV7064
3USP 33K5 3333 3U35 3UUK
d
2(
%ä•ßg!À[
>DA
^o
,1Ee2()9*>DA#aFk*&`#&k*]1&-+1:1#-]&F8
d
L(
•³´À¥ÌGÙÄ[
>DA
^o
,1EeL()9*>DA#aFk*&`F*-+1$aFTd1&%-FI*F8-: ]9*#&%0
d1-]1&

!
œ
!
èÏ

æ‡Vj
!
m­üw
!
ÎÏÀ0

æ
ç‚&›=>Q6ɛeœâ®
#
d|œ•÷
#
•
‡j
#
†&L
#
|œ_,÷‡

RÐèÄ›0±K
RdœrÏ[5Å
K05(
!
ðFèYZ­àǵÌ%
WÑÃł_…ì
!
æçhȨ̂¨Æ§ªVè
n][²Dœ
S(

¤ƒ„€R™5ܕ0±‡~°
!
ª«•³´
•6,LDê‚

=Û·Ù³´KR_©
#
­

!
{
6S
8Ôè6Pœ¿D

{
K6
8´¿Û·
ٌ¼R•6,_tÂÃÆWßî
!
m<°ØÜÇ

!
=
#
nÛ·ÙVj5KR½u,â
!
m(væ
(f™
!
ÜÇ
2
óôèé*•tY6Pœ÷ÂÃf
­
!
šY»¼\‡

ïj–Ø6³´*a

2wè
é]_©[
K
7š-
!
¿Û·Ù•6,Xè01
ÔèXÊbÆW
#
×{g‡E9

b[=!A>!a)H
]Üǖš™¼R<°[«|
åÓ
!
AYR¡vhØ,pu[Îì

j‰ƒ„V
è1M|Z—Ñ

ì
aC7b
{
K6
8´v¢œ
/26L5/
{
5P
ï{
K5
–
K36K
÷
6K
³
(((((( ( ( ( ( ( (((( ( ( ( (
B&+e5P!V88a*(K5
@*#*%d*F!K36K
3=
!
<°ØÜÇé
!
*µ½•³´[€ã

ÆǾ
Œïj»9


=YC7!ZV;06!V7064
{
6S

v¢œ3=
!
ïj–é=Û·Ù
ZV;06
}èv¢œ
3=

0ÄL¥³´
!
ªD\[©–œGãÌ]
@¶&*¨Æ
>DA
^o6Œ„F[µ¨égÕ
Õ=
b[=
Ñ
A>!
mCExèä.]@¶


ĵ%[
>DA
TUßت
3eU2
•³´%ä[µC…”ûã\!ÀJL¥µ
C
!
ø@³´}Ú¾[¼R
!
]©–†°|Ô[ÝÇ
œ

•÷;±°€R.™¡è™%Ý_[•³´À
¥Ì
=YC7!ZV;06!V7064
‡
!
ÝǜŒt
b[=
Ñ
A>!
>]æç•X¬L
#
Ç̜•Ïœ
#
à8,}Ñ
Ò¾[•³´‡™¯°´*.|Ô[©–™%E
›

j^Qó
!
K°À¥Ì*,a´S°ž¯
!
æ
çµ%[§›œSŒ

ZV;06
@|¡C.½uY
!
]…•rY¼k
!
]
»9Ú±•XrèX“¼k
!
ì€ã†QJrϜ
³´7
!
ó6\•‘6,_tÂá¼k
!
ZV;06
[®ßg,„¾[äÌg²m¡K°]
K
2(
!
ÄYµ%K°r
ZV;06
‡ñ*šÞݕX
°e@•6,³´R´
ZV;06
[Ý_‰K¼R]
A†QœJ•Ïœ8²[•³´[©–ÑA•
6,_tÂÃ[=°Eœ

ìm[KR7š|Ÿ
]•³´€ã¾[
6K iKS 9
~3=Ï|
!
q®]v
vÛ8²[•³´
#
|ϥL
#
K/ÇÈJª€ÈÄ
”´[•³´r¼kYv¢

=YC7
@{YI|½u æõr[|5
!

iTŽ|þ0điÂÃrŽ[KI
!
H¯•ÂÃ
×ã
#
¾jGP?

‚&]f´ÂÃ*JÈr¼k
!
]•X•‘6,s¨œ
L(

Ï_tÂÃ)*‚_
7åv¢=¼k
P(

ª·ƒ„Ƨ
!
A–¼[†Q
œJ•ÏœÊÌËâ
!
KRdœ•³´¾pÇ*]
QóGK°rµ%*
=YC7
m¡X@Jsļk
Š6Œ
!=YC7
@Eê|R©
#
R*+[`8sÄ
G¼käÌ]•Xr·µ%K;

V7064
@|¡‚&oH*xiÂÃäã[1÷
…ÂÃÄj

dœ•³´¾]•‘6,_tÂÃ~
·`8¼k
!
Ã~[¤à@½uG
#-G8-8*06
Vªo
,‘œ[hþ}~K\ê‘\}~
4(
!
¾MÑ6,
°r

K
V7064
[ÝÇ_=
!
A†Qœ•³
´xè°Eœ
H-F1I9
‡
U(
µKmV*EêVdœ
•6,ß€©â[dœ•X¬Lr,6˜;
[èéNx

YZ[À¥ÌA•³´Ýøxè¿l[t-
ÑÝ_
!
ì@ϙ¡À¥Ì¸ÄÝ7
!
ªµ¨ég
]|Ô­_Sê‰K
!
g²S9/[ۗ•³´

|Næ烄ÐÌƧÀ¥Ì¸Äµ%[Ý
_
63066(

A
a=YC7hZV;06 hV7064
[¸Äµ%
!
­
®|uæ烄v½
.
K
=YC7
]Ò¾
K 9
˜™¼
kf™
!
Ò¾
L 9
*k0_
&
K
V7064
‡ñ]Ò¾
L 9
˜™æ(3=
!
Ò¾
6K 9
*k0_

=!À[<°
7šsj‰œ

>µKK
=YC7
ÑK
V7064
*E
Ꝑ•³´[©–™%œe5ÀÁÌ
6K(

f
ZV;06
]•³´€ã[
6K iKS 9
~D\Ï|
!
¼R
K|Ô[š¾œ

²
!
s[
5
!À[ÙÄ
!
²Ù
Ú_¼RK
)
#yČ
*
[0ą~
!
²7š6Ò_
;§`
)
JÞ&Ï
*!
—ò.•³´[©–¹g

ë)7«5Å
65(
!
s՞›.0Ä
7&E18]1#
É
*[
>DA
^o6Œ…”

ƒ„r
a=YC7h
ZV;06 hV7064
ÙÄA0±²²[ª«•³´Ëâ
[
7&E18]1#
É*…­
!
*›Éî[¤[³´™%

V%Ô[K°
=YC7!ZV;06!V7064
[Z·_ôх
­Ô*&*/[¤[™%¢<_

iÙÄ]/Ëâ
[R}U_j^
!
<ª¥*d•³´[]

›_²£
!
™5ܕ
S3!K3 E/IE
<6
0±‡~°
*²ª«•³´
!
•6,ê‚&ØI
!
•6,_
tÂÃÆWßî
#
½u,âê‚&¼R
!
³´­i
Û·s»j‰

%ä•ßg!À
b[=
Ñ
A>!
žè
v¢œ3=
&
f•³´À¥Ì
=YC7!ZV;06!V7064
[v¢D\™©9Óã\!À[3=ÑL¥³´
[KR
!
]|Ô­_™%Jµ½.Ç̜•³´
[€ãрN
!
ª¿l°è[ãÌ]@¶`¼RK
A•³´ØI[°Eœ

ª¸Äµ%¼RKc=[
µ¨Ý_
!
g²S©
#
S+/[™½Ñۗ•³´[
ìí
!
*›Ç̜•³´[Ý

$
ƒ„…†
%
6 ((
õ!
!
õ7:
!
ýWV
!
‡
e
0±ÇÁr0±Ø£ß[Z·

O(e
7ª­<­Ç
! K363! K6$2%.63LLe
K ((
1ãø
!
„ãD
!
„)
!
‡
e
dœ0±rÏ
63
Žæç6Œ
O(
r­N¾<]¤¥
!K332!64$6%.5Ke
5 ((
/tÓ
e
r-<0Ä=>dœ0±rÏ
KL
Ž
O(e
BHr<
Ǫ]]5
!K363!5S$K%.KK6e
S ((
õW¡
!
C*ñ
!
/À[
!
‡
e
rÇ0±`€6«®¢ÂÃX
*<[§¨ƒ„
O(e
r­tãiN%¤¥
!K336!U$2%.S6e
2 ((W9-EW!Ja%G9F*T8b@!b&Fa*]F*OBe?9*::1E&`]9*aF1-FT
/L6L5/
{
5P
ï{
K5
–
K36K
÷
6K
³
(((((( ( ( ( ( ( (((( ( ( ( (
B&+e5P!V88a*(K5
@*#*%d*F!K36K
d1&%-FI*1I1:*T1$aFT%&+*#a+*06$ZV;06%18F*Ea+-]*: dT;CH
I1-8*8-: $a.]-%*%dF-*F*E1&O(eOC%?&#=*G9F&+!K33P!
64$63%.KP36e
L ((Z$*+:8* 7!A&!+-: Ob!b&F*E--F: =eJa%- *a]F&G91+E*+-]10
-8*-88-]*: +1G&#-+1 -: 9&%&+&E&a8GF&]*181 F-]-: %&a8*
O(eb1[%b1&G9T8C#]-!K333!6S4K$6NK%.KPKe
P ((;189F-O!;-\! HF-:-C!*]-+eV:*]1`1#-]1& &`*a]F&G91+E*+-0
]1-8*0-88-]*: +1G&#-+1 -8-&k*+*-F+TaF1-FTd1&%-FI*F`&F
18#9*%1#F*-+1$aFTO(eOC%?&#=*G9F&+!K335!6S $63%.
K25Se
4 ((;*+1I&kB_!/#:*F)!,-]acc1Y!*]-+eV%G-1F*: V7064 GF&0
#*881EGF&]*#]8#-8G-8*060:*`1#1*]%1#*`F&%18#9*%1#-#a]*F*0
-+`-1+aF*O(eOA+1 Vk*8]!K336!63P.66S2e
U ((H-F1I9 A>!O-1C!;*+1I&B_!*]-+e[F1-FT1]*F+*aI1064 18
-d1&%-FI*F&`9a%- -#a]*]ada+-F*#F&818O(eC%OZ1:*T
@18!K33S!S5$5% .S32e
63((
&ã­
!
üãk
!
ú#Ý
!
‡
e7&E18]1#
É*Ñ
>DA
^o݀
ݵ%–¡K½u]^A©–•6¦¬L[Ý_
O(e
r­r-<0ĕL¤¥
!K366!6K$4%.LU2e
66((
éÎã
!
š÷Œ
!

!
‡
e7&E18]1#
É*Ñ
>DA
^oÝ
4
¡
ȀœÊ‚§¨á!À[æçÝ_
O(e
ü<]
!
K363!56$K3%.KL23e
6K((H-F1I9 A>!;189F-O!)91*88* H91+dF&&I J!*]-+e[F1-FTV7064
18- *-F+TGF*:1#]1k*d1&%-FI*F&`-#a]*I1:*T1$aFT-`]*F#-F:10
-#8aFE*FTO(eZ1:*TV]!K33L!P3.6UUe
65((
&­X
e
͛
?H??
E™D·èé_[
>DA
^o6Œ
O(e
r­—Ð+ã
!K335!6U$U%.6626e
2E/G/LDAG0KD0LKBNLE/CWAK0CIG0C/GF 5]6;! _4>-6 /CH4;-64 0C
PEFDB1/LL/A:/H0Q-0CHILAHGAC/10C`IGF 0CG/DK/CH
K0WC0N0L/CLABNLB.M0CAHHADALD0BC
7V_10`*1! X[)1E0]1E! _CDYa-E0]-&
!
! OV=>a&0%1
$/2-1;2-0M10E4,(0!67C,-*0!01-.#2014(484*0+014! /2-1;2-0K36K35! #201-%
6MKDG/LD(8M`ALD0SA. )&*.G+&F*]9*#9-F-#]*F18]1#8&`#9-E*81 *a]F&G91+E*+-]1-8*0-88-]*: +1G&#-+#1 $=YC7%! I1:0
*T1$aFT%&+*#a+*06 $ZV;06% -: 1]*F+*aI1064 $V7064% 1 H9T]&+-##-*>-:1.01:a#*: I1:*T1$aFT1 F-]8-: ]9*81E1`1#-#*&`
]9*#&%d1*: :*]*#]1&e>ADEBH. ^18]-FF-]8!*F*:1k1:*: 1]&]9F**EF&aG8.91E9 -: +&!:&8*$#Fa:*:FaES3! K3 E/IE
<6
/:
<6
%
H9T]&+-##-*>-:1.:*#&#]1& EF&aG8-: ]9*#&]F&+EF&aG! -: &F-+T-:%118]F-]*: !1]9 :18]1+*: !-]*F&F*Ra-+k&+a%*&`H9T]&+-##-*
>-:1.:*#&#]1& &`F52 #&8*#a]1k*:-T8e)9*1Fd+&&: -: aF1*8-%G+*8!*F*#&+*#]*: & :-TP! 6S! K6! K4! 52!SKe)9*--]&%1#-+
--+T818!-8#&:a#]*: &`F*-#9 EF&aGe)9*#&]*]8&`8*Fa%]&]-+GF&]*1 $)H%! -+da%1 $C7b%! d+&&: aF*-1]F&E* $b[=%! #F*0
-]11*$A>% -: aF1-FT)H-: C7b!*F*:*]*#]*: dT%*-8&`d1 *%1#-+--+Tc*Fe)9*#&#*]F-]1&8&`aF1-FT=YC7! ZV;06
-: V7064 !*F*%*-8aF*: dT*cT%*0+1I*: 1%%a&8&Fd*]-88-T$/7V?C%e)9*%&FG9&+&E1#-+#9-E*8&`F*-+G-]9&+&ET!*F*&d0
8*Fk*: dT+1E9]&F*+*#]F& %1#F&8#>e)9*#aFk*-F*-8&`k-F1&a88*Fa%&FaF1*1:*.*8-: ]9*#&%d1*: :*]*#]1& !*F*#&%G-F*: dT
F*#*1k*F&G*F-]1E#9-F-#]*F18]1##aFk*$>DA#aFk*%e:AKI1D. >-]8!*F*E1k* H9T]&+-##-*>-:1.:*#&#]1& -]]9*:&8*8&`S3!K3 E
#Fa:*:FaENIE:-1+T`&F52 #&8*#a]1k*:-T8]&1:a#*I1:*T1$aFT#9-F-#]*F1c*: dT]9*:*E**F-]1& &`F*-+]ada+-F*G1]9*+1-+#*+-:
GF&]*1 #-8]e)9*1$aFT!-8G-F]1-+TF*k*F81d+*:aF1E]9*F*#&k*FTG*F1&:eA&%G-F*: !1]9 ]9*#&]F&+EF&aG! ]9*#&]*]&`8*Fa%
b[=! A>-: aF1-FT)H1 *-#9 :&8*EF&aG %&8]+T89&!*: -:&!!-F: ]F*:eD :-TK6! ]9*#&]*]&`aF1-FTC7b&dk1&a8+T10
#F*-8*: ]1+]9**: &`-:%118]F-]1&e)9*#&]*]8&`aF1-FT=YC7! ZV;06 -: V7064 d*E- 1#F*-81E& :-TPe?1#*:-T6S! 91E9
-: +&!:&8*EF&aG889&!*: 81E1`1#-]:1`*F*#*$%g3e36%e)9*91E9 :&8*EF&aG *k* 89&!*: &]-d+*#9-E*8:aF1E]9*F*#&k*FT
G*F1&:eC##&F:1E]&>DA--+T818! ]9*#aFk*-F*-8&`=YC7! ZV;06 -: V7064 !*F*3e4SL! 3e45P -: 3e4L5 $%g3e36%! F*8G*#0
]1k*+T! %a#9 91E9*F]9- ]9-]&`b[=-: A>e)9*-F*-&`]9*#&%d1*: :*]*#]1& !-8aG ]&3eUSPe2BCL1IK0BC. [F1-FT=YC7! V70
64 -: ZV;06 #&a+: &`F*#-8]-: 1:1#-]*]9*&##aF*#*-: :*k*+&G%*]&`F*-+1$aFT]&8&%*:*EF**! -: 89&!91E9*F8*81]1k1]T
-: 81]*8G*#1`1#1]Te)9*#&%d1*: :*]*#]1& #&a+: a`F]9*F1%GF&k*]9*]*8]*`1#1*#Te
_AF UBGHK((=YC7& ZV;06& V7064& #&%d1*: :*]*#]1&& H9T]&+-##-*>-:1.& >DA
HB0.!+c%#)RL`L..#+!##$##
$
‡ˆAD
(
‰Š
%
/P6L5/
{
5P
ï{
K5
–
K36K
÷
6K
³
(((((( ( ( ( ( ( (((( ( ( ( (
B&+e5P!V88a*(K5
@*#*%d*F!K36K