免费文献传递   相关文献

Effect of Tongluo Xingnao effervescent tablet on learning and memory of AD rats and expression of insulin-degrading enzyme in hippocampus

通络醒脑泡腾片对AD大鼠学习记忆和海马胰岛素降解酶表达的影响



全 文 :BSTUVWXž
3H
ŸNYZ[›
M\]^˜_`aQR…§¨
3äA
!*
!
åæ
*
!
‰c
!*
!
çEè
!*
!
tÓá
!*
!
!
*®é
)
c
ª«€ÃMv…†QR_YñwN5bcdefg+yt©
!
ª« ¤¥
#)%%
*c
¤¥ÃGM.ª
!
ª« ¤¥
#)%% )c
Ã5ÃGHªI
!
JK
$$%$$#

fg
#!
P~
#
Â@BSTUVWXž
3
!
*4)
M\qX³Ú۟NYZ[›M\]^˜_`aQR…§¨
$
–wQ§
CqÚÛÕ{|–
*

#
ûÌ
3
!
*4)
M\qXÚ۟NÜÝ
$
ž;ܟNÖÞ¦–ÜݞIO
+
!ΆO
!c& /F/\F
e
+
BSTUVWXü
+
$
+
ˀ¢O
!%c#$)c%($c7 F/\F
e
$
qÖM\qX|ŒpÁ…ŸN–ì/)O
$$ /A/\F
e
$
ws

ì
$
”?p¸e,
7$ M$
݂
9.VSN
ÁÝäœàŸNYZ[rÛ
$
݂É5OPD›i=¦()žŸNM\]^˜_`
aQR‘fÍ¢¦
*
‚
#
BSTUVWXrÍLOÖTŸNÍ]Þfà›…ßÈGûx
$
LO~}”ìÂwà›vó3
HËäT웳ËvQ3HËäTì
$
WøIƒÞì?
$
£ÜÝO³ÆGLOV­
!!u$c$$
­rÍLOÕüM\O]^
˜_`aƒA™[
$
ÕüM\O]^˜_`a…QR
$
£ÜÝO³ÆGLOV­
!!u$c$*
ƒ
#
BSTUVWXsGÕ
ü
3H
ŸNYZ[rÛ
$
ý‘M\]^˜_`aQR…·‚
$
Õ§wꚷ‚£ÕüM\]^˜_`aŽG€
*

hij
#!
BSTUVWX
,
YZ[
,
M,
]^˜_`a

kl)(
#!*$)4$)4)

y z { P
# !
% ú
%
¼ Ÿ ˜ ,  ~
&
& ( ¼ Ÿ ‡ 
!*$)BD$7$)$$*4$$(,
©ªÑ q)()}®æ¶4)
!*$Cb$$&,
©ª)›()}®æ„Pfp)
!
¼à
,
©
ª
%
ŸóR
&
À)
!*$$8B$7,
©ª€È}B›&¼à
)
!*B3$&,
¥24¬‹e’()À¶4
4
üþ{f†‚ý°
)
!*HDQZ)*C?4$$*

mdno
#!
!
=%ü
$IEW#!$*( #($$*)$Y4/LSW#M.-6X2*#,
-./

no„…
#!
Ñà
$IEW#!$*(#($$*)$Y4/LSW#[RL1F5S10SE((2
#),-./
!!
[\]M^#
!3W[RES/EVrNMSNELNE$3H
ñó±
£qª–—#€…¦øÐfŽ #
$
e#Þ~•ð
$
÷ø¥–
#
á΍Á抅v

°gEŠ<
-.
*
3
!…Zeñ)*Iÿ–
3H
…$XR×ÎùÚ<
˜
-*.
* 3H
Ā7þ
3
!¬|›’¯º·
$
FgIÙ
…
3
!µ¿¥2ЎâµÈ‰¬|¦øjŽ
*
<=
}~
3
! IÙ¬|›’¯âµD…
3
! §¥–
3H
§®…¼9Œ×
* %
a_`·‚
&

3
! ’¯$sG
¼9·‚
$
w$
:HY
ñU$EG…
3
! _`a¿
ó
-)4&.
$
ÀÁò
3
!_`a
!
m
:HY$
µBIW
3
!
ˆÈ8…’¯RN¼û
3
! Usƒ·ŒÈÁñ
3H
§®›‡Q…lÔ¿ó
$
É)*Ê>õN#€c«
*
BSTUVWX7ª²Ý,O¥
$
sGBSTU
$
`
jꚅ·‚
$
‘óO*xQð
$
ë~€sG±
²
3H
YZ[ßr
+
ý‘M\‘Ú˜QR
+
}~M
›
J8a4)
QRÝ·‚
-4#.
$
4ˆý‘U
8
3
!’¯…{
$
{ãÓwž
3
!
*4)
g
3H
ŸN
YZ[rÛÎM:HY
…QR…§¨
*
!
¯H
V!
,{
!
BSTUVWX
$&c F
Š|,
=
X
$
7
4‘óOB~
$
¸<
*$$$)$&,
p†Ùiãs
!

Ü
$
°¯
!
$%

~,GHIJ|¬
$
¸<
$$)73*
V(!
Ú{
!8H
ŸN
$8@K
&
$) d&

$
aËpÔ
$
ȼ
!*$$ l*$ F$
7©ª·&{cœÚ{
fÕ{
$
Ú{<
8ª
*$$(4*&*
V&!
›€
!
N¾~€‡X0
!3
!
*4)
$8SF/L
IJ
¬
,8Q@
óA
#GN4$$(9$
äAŸN
:FJ$
23…l
ƒ|{()GHIJ
,
AA
+
QA›
H3Z
L§›€
˜A723$Ïp_|{GHIJ|¬
*
V_!
Ñê
!HP4
ŸNUÌÈÍ°Ñ
!
¥2Ԟ&
(GHIJ
, 83Y8?:; 7$ h$*
ZÚ¬&å
!NLENRS1 ]VE-SNS.1 <.c$ATM,9I4*$$ 9.VSN
ÁÝä
!
¥2Ԟ&(GHIJ
,:/LFE4@V.@WXN#c$
i=
¦©Ð
!
n%
9EMSL<5GEV1ETS-N$ :1-c*
/)#(*/
v
)(
Õv
%
x
*$)
q
7
r
!!!!!! ! ! ! ! ! !!!! ! ! ! !
.^Wc)($:NNXE!%
8E]TE/GEV$ *$)
(!

(V!
ÜÝ~ÝΦO
!3
!
*4)
ÐÀ
$c7g
|ŒpÁ
!
򜝖
* F/A
e
$)% f
Ú,^šÈ
%* R
CD
݂
*
ç{Cž~ÝÜÝ
-4#.
*
žŸN‚
$c)g
Ð
„³ÑC£•8µÅ
!)$ /F/\F
e
$$%
Â
$
Ýc
$
ž
ŸNḈUÌÈÍ°ÑÁ
$
‚?û
%g
àzô•
7j®cÂ
$
‚Åy/)恟N®c`$ŽC—
¯ó}K
c -/
pf—³
$
`å*ç
$
œŽ¦‡c
ÓOPÎÕ<
$
›ÂؖŸNUÌÈÍ°i%
$
‰
ŸN*çÂ
)c$ //$
Áþ
*c$ //
C‚Åy¬&å
å¯èÕ
$
‚

&
A
â‘~êBèÕ¯(C‘ÀŸ
NÁþM\Í1
$
‘>X
)c) //$
gÇ!qX

&
A
ϵš
3
!
*4)
$
qX!–

&
A//S1
e
$
þ

/S1
qX?é
$
ä>
* /S1$
gê>
,
–~lԁ‚
þM\1qX

&
A
ϵš
3
!
*4)
$
;¥³Ú۟N
ÜÝ
*
)Âí
$
7j
$
ì/)OqXÝæe…
|ŒpÁ
$
)ÂB7ÏP

$
*
žÀ…ÜÝÚ{
#IȼÖÞ¦–

O
$
µÜÝO
+
!5ܞIO
!c& /F/\F
e

›BSTUVWXü
+
$
+
ˀ¢
O
!%c#$)c%($c7 F/\F
e
$
wO
$
r
$
q֖
¸ì
$
r`ôŸN
$
–~r·lÔ
$
M\Í1qX

&
A
|ŒpÁ·–ì/)žIO
*
¯ì/)O›
ÜÝOŸNp¸eÕÝÈe…|ŒpÁÏ
$
w2p
OŸNp¸#†…,{
$
e,Èe–
$ /A/\F
e
$
wl

ì
$
”?p¸e,
7$ M*
(V(!9.VSN
ÁÝäà›ŸNYZ[rÛ
!
Í]
Þf›”ìÂwç{Cž‘f
-4#.
$
¦`ZÛßÈG
ûx›vó#HËäTì
+
ƒÞËäTìÎøIƒ
Þì?
*
(V&!
v4~ݛ]^˜_`aQRÁƒœà
!

ìe,
*& R
Â
$
CEŸN
$
ÅyÑÒÓÖÑUOP
$
ô•ÇÍ
$
V{hÐÂ
$
f”?§y—X
$
XYK
*$ d)$
&
/$
w%


*
X
$
—XMåë*Â
8@
Ô
fÉ5OPDM†
*
sÈlÔçIðj‘f
*
jÖM\—X݂
:/LFE4@V.@WXN#c$
i=¦©
Бfi=¦
$
w—v4à

їX
$
wїX…
w,àÍ1°ÖÞjÖ
)
,É
$
փA÷
*
fG
ƒA™[àÍA#–…[ÑÒÓ?¥
*
é
Ž
#
•“$
4
“$QRþ=>¥
$
êŽ=>¤–à$
*
(V_!
ж¦
!
?–
>l,

$
pO?–^
`š¦¤‘fª<˜lV¦
!O1E4PL53;O^ 3$
lVsT݂
*
œœ
$
lV•sT݂
*r
œœ
*
&!
{L
&V!
BSTUVWXž
3H
ÜÝYZ[rۅ
§¨
!
7Q

›Q
*

$
ÜÝO£ì/)O³Æ
$
ßÈGûxLO~}
$
vó#HTìLOÖT
$
vQ
#HTìLO~}
$
øIƒÞì?LO³Ë
$
GLO
…жÇq
!!u$c$,
e,O£ÜÝO³Æ
$
B
STUVWXü
+
$
+
ˀ¢OßÈGûxÆÜÝO
LOÖT
$
øIƒÞì?LOÙ
$
vó#HTìL
O~}
$
vQ#HTìLOÖT
$
GLO…жÇ
q
!!u$c$*
Q
!
BSTUVWXž
3
!qXÜݟNßÈGûx…§¨
!

>l,$&m7
ILGWE!YUE-TN.UI.1FWX.DS1F1L.EUEViEN-E1TTLGWET.1 WLTE1-5.UEN-L]S1F.US10E-TS1F3
!
S1 TRERS]].-L/]XNVLT/.MEW
!

>l,$&m7
O`
€¢
=F/\F
e
ßÈGûx
=N
ìÒ
M
ìÒ
* M
ìÒ
) M
ìÒ
& M
ìÒ
M
ì/)
e 7c l
c

%c l
&c
*
c$ l
c*
*
%c l
)c#
*
c) l
c)
*
ÜÝ
e *$c) lc* (c lc 7c* l%c# *&c l#c$ #c& l#c%
鎞I
c& %c l
*c%

c# l
%c

(c& l
c*
*
(c% l
)c
*
7c* l
&c

BSTUVWX
%c# *c( l*c) *c( l
#c(

(c% l
c$
*
*c( l
c)
*
(c7 l
&c$
*
)c%( $c7 l$c$ %c l
)c&
*
(c# l
&c&
*
$c7 l
&c)
*
(c# l
)c&
*
c(7 (c( l#c$ c l
c7

*c* l
c

)c) l
%c
*
7c) l
&c7

!!
q
#
£ÜÝO³Æ

!u$c$$
*
!u$c$,
鎞IO€¢ª°–
/F/\F
e
!
Q
*$)
–
*
&V(!
BSTUVWXž
3H
ÜÝM\O]^˜_
`aQR…§¨
!
7i


$
ì/)OŸNM8
:HY
…éŽQR¬{^•“$àXyEM¶y
$
89¦¤¦ø´8
$
G.M¶%q¦øy$%
$
í«Ñ¦øy>ța‘…¿î
$
‰‡+Îâ+
=>¦¤O$la[G
:HY
Ñx
*
ÜÝO
:HY$
/&#(*/
v
)(
Õv
%
x
*$)
q
7
r
!!!!!! ! ! ! ! ! !!!! ! ! ! !
.^Wc)($:NNXE!%
8E]TE/GEV$ *$)
!!
Q
*!
BSTUVWXž
3
!qXÜݟN”ìÂw…§¨
!

>l,$&m7
ILGWE*!YUE-TN.UI.1FWX.DS1F1L.EUEViEN-E1TTLGWET.1 N]L-ENELV-RS1F.US10E-TS1F3
!
S1 TRERS]].-L/]XNVLT/.MEW!

>l,$&m7
O`
€¢
=F/\F
e
vó3HTì
=N
vQ3HTì
=N
øIƒÞì?
ì/)
e
)%c* l7c)
*
7c7 l&c)
*
*c( lc$
*
ÜÝ
e *)c) l)c7 *%c l%c# $c% l$c
鎞I
c&
)7c* l%c)
*
*$c# l#c*

)c$ lc
*
BSTUVWX
%c#
)7c l(c#
*
*c$$ l&c(

*c% lc%

)c%(
&c& l%c*
*
7c7 lc
*
*c# lc&

c(7
&$c* lc(
*
*$c7 lc)

*c& l$c7

É5è$ׅ
$
éŽQR³ï
$
ðLËþ`ôO
,
B
STUVWXpe,OŸNM\O
:HY
…QRA
ÆÜÝOè$×X
$
QRðLÀ
$
Õ§BSTUV
WXsGý‘
:HY
QR…·‚
*
3c
ì/)O
,Zc
ÜÝO
,鎞IO
,Hc
ü€¢O
,Yc
$€¢
O
,Kc
ˀ¢O
*
i
!
BSTUVWXž
3H
ŸNM:HY
…QR…§¨
!$ j&$
KSFc!YUE-TN.U:HYE6]VENNS.1 .1 3
!
*4)
S1MX-EM WELV1S1F
L1M /E/.V5M5NUX1-TS.1 S1 VLTN!$ j&$
&V&!
BSTUVWXž
3H
ÜÝM\]^˜_`
aƒA™[…§¨
!
7Q
)

$
£ì/)O³
Æ
$
ÜÝOM\O
:HY
ƒA™[LO_Ë
!!u
$c$,
BSTUVWXp€¢O£ÜÝO³Æ
$
ƒ
A™[AÆÜÝOLOü
!!u$c$*
Q
)!
BSTUVWXž
3
!qXÜÝM\]^˜_`aƒ
A™[…§¨
!

>l,$&m(
ILGWE)!YUE-TN.U.UI.1FWX.DS1F1L.EUEViEN-E1TTLGWETS1 TRE
:HYLiEVLFE.]TS-LWME1NST5.1 3
!
*4)
S1MX-EM WELV1S1FL1M
/E/.V5M5NUX1-TS.1 S1 VLTN!

>l,$&m(
O`
€¢
=F/\F
e
+6
ì/)
e $c)
l$c$%
*
ÜÝ
e $c$( l$c$#
鎞I
c& $c%
l$c$&
*
BSTUVWX
%,# $,&$
l$,$)#
*
),%( $,$(
l$,$#
*
,(7 $,$%)
l$,$$

_!

3
!âµÈsGÉM\/Ž
$
£
3H
¦øy‘Ú
HI–—#€
$
§¨Ó‘Ú2·ŽÎEFßr2F
gZ[jk
*
_`jkñ
3
! ¬|ZN
+
Fg¦ø
H&…¼9uv¿ó
*
]^˜_`a
!:HY
ñó±
89¹`sG !ïӔì{|€‡+
!
°¤
+
Á!
_`]^˜…a
$
\éþ¥d¦øy…=><
+

ÑÒÓr2_`
3
!
$
ëarBI/ÍKð͛_`
3
!èò׍È8…
3
! ÁƒÎ=>8…
3@@
-&.
*
:HY
QRÓ_Wñ
3
! µ¿
$
QRÙr_ËU8
3
!Áƒ
$
8Ù
3
7_`a$·‚E–¼9
-%.
*
æ
UOPòœex
:HY
Àqª£UO|¶…€‡
+ÁƒÓ_
$
CqU˜wñ
3H
U$
$]?

$:HY
ŽLOÓ_
-(47.
$:HY
ºÚÃ
4$$*I=4<
2LO
Óò
:HY
…QRÁƒíŽuæŠ
3H
…e#Ãó
W
$
뷂2r
:HY
òi
3].Y
8
&
Ý°ý€
-$4 .
,:HY
3
!
&$=&*
Áƒ
LOÕü
-*.
$
ë:Nè@…ŠU„P¦øyÀ
3
!…_`nô
-).
*
ý<§®…{LrL§
-&.
$

&
rª?
:HY
ý<:N
$:HY
…QRW
*
(
$
N
¾~4¹ZeLO³:
*
{›EF…
3@@
?ý<
]^˜jA:NN¾~4¹W›
:HY
ŽÓ_
$
3
!ÁƒFü
-.
*
Á提AQð
$:HY
…Ž
ñÍU8
3
! …¢ÁsG¼9·‚
*

$
1
:HY
ŽFüT
$
2´ˆâ†
=
cↀ‡´a
Z
B
S
$
}~
J8a4)
!…Ž
$

ILX
€‡…­ô†
D
-#.
*
4cœ{LQð
$
BSTUVWX•)2
LOÖT
9.VSN
ÁÝäàÍTŸN…ßÈGûx
$
£ÜÝO³ÆGLOV­
!!u$c$$
‰®2L
O~}”ìÂwàÍTvó#HT웃ÞËäT
ì
$
LOWøIƒÞ…ì?
$
£ÜÝO³ÆGLO

$
ðBSTUVWsG±²
3
! M\qXÚ
ÛÜÝYZ[ßr…·‚
,:HY
É5ODœà{
/#(*/
v
)(
Õv
%
x
*$)
q
7
r
!!!!!! ! ! ! ! ! !!!! ! ! ! !
.^Wc)($:NNXE!%
8E]TE/GEV$ *$)
LQð
$3
! M\qXÚ۟NM:HY
LOËQ
R
$
£ì/)žIO³ÆGLOV­
!!u$c$$
B
STUVWXp€¢OŸNM:HY
QRÆÜÝ
OLOW
!!u$c$$
Õ§BSTUVWX2
WëŸNM:HY
…QR
$
àw2BIÕü
:HY
Ž‰ý‘
3
! …_`
$
ˆ‰RNò×U8
3
!
̚…·‚
*
p†Ùiãs
!
!Ά

ñó±üj

+
œ¤¥Ž
+
2>Ž…‹5a}~€
$
rÍÕ
ü$õ©Ð
$
/`ñŸUc+›ýWצø‘Ú$
à,‹œ
$
ˆ‰±²ÚÛĀ…ÿÇßr
$
É[
G_`
3
! …·‚
*
4›œL§
$
!ŒÜOŸ
NM:HY
QRÓÀ
$
ÉGc«‹5a}~€
!
ˆDŽ…ð

2ý‘]^˜…¦F
-%.
$
‰I¢QR
…]^˜r£
3
!¤¥{î
:HY

:HY
…ŽÓ
_
$
ˆ‰³UOP$
3
!…_`›’¯
-(.
$
@ñó
,÷ûXÀ…ö÷x3
*
<=
$
°›4{
L¤ìÕ§BSTUVWX2BIÕüŸNM…
:HY
Ž
$
ˆ‰ý‘
3
!…_`›’¯
$
RN±²
3H
¦ø#ŒH&›YZ[ßrÝ·‚
$
É
:HY
¯Ó_`
3

$
Êr_`]^˜
$
ÀBSTUVW
Xñô+ž$õ›Ï$wx1¦
:HY
Ž¬|§
¨Îñô+¬|wx•kM†Êb‘ó쏐
*

pqrs
#
- .!3W[RES/EVrN3NN.-SLTS.1c*$$( 3W[RES/EVrNMSNELNEUL-TNL1M USF4
XVEN-C.c3W[RES/EVrNHE/E1T$*$$($&!*#$c
- * .!?LVM5C3$ 3S`` S1NJ3c3W[RES/EVrNMSNELNE# TREL/5W.SM -LN4
-LMER5].TRENSN-C.c8-SE1-E$77*$*#!$&#(&c
- ) .!ALKEVWLK9$JVEE1 a;$OMM.8c:1TVL-EWXWLVL/5W.SM4GETLS1
3W[RES/EVrNMSNELNE-C.c;LT>Ei# ;EXV.N-$*$$%$(!%#&77c
- & .!ASX QD$JXL1 ?C$ZE-\ETIAc+& 2$*?.L1M $& 2$2.MEFVLMLTS.1
.U3
!
]E]TSMEG5]E]TSMLNEN-.X]WEM T.EV5TRV.-5TEN-C.c@E]4
TSMEN$*$$%$ *(!*# *)&c
- .!
=%ü
$

$
Ñà
$
Ý
c
BSTUVWXž
3
! M\qX
Ú۟N
TLX
€‡†D€`òi€‡
›
J8a4)
QR
…§¨
-C.c
_P,-.
$*$)$*(!*#&$c
- # .!
Ñà
$
=%ü
$

$
Ý
c
BSTUVWXžÚ۟N‘Ú
˜QR…§¨
-C.c
$,,Œ£™š
$*$*$*(!)#(&c
- % .!
Ô/±
$
øR
$
(.L
c
]^˜_`a[\]M^#e#
Þ~$…‘’
-C.c
|Î&
$*$$7$*!#*#c
- ( .!
Ò0
c
E莣œEèŽÚÛp
#
ù#j#£[\]M^#
-9.c
23
#
&ѹÖ
$*$#*%&c
- 7 .!aXV.-R\S1 :^ $J.T.8,3W[RES/EVrN
!
4L/5W.SM ]E]TSMEN]E-SUS-LW4
W5S1TEVL-TN+STR L1M SNMEFVLMEM G5S1NXWS1 MEFVLMS1FE1[5/E
-C.,KYZ8 AET$77&$)&! # ))c
-$.!
‚Jn
$
!i
c
]^˜_`aý<ºÚÃOٚŽ£ÉeŽ
[\]M^#…€©
-C.c
U£¦ø #-.
$*$$$(!)#
%7c
-.!ZSL1 A$ QL1FCH$ JX.IP$ ETLWc:1NXWS14MEFVLMS1FE1[5/E
L1M 3W[RES/EVMSNELNE# LFE1ETS-LNN.-SLTS.1 NTXM5S1 TRE?L1
-*.!9SWEVZ<$ Y-\/L1 Y3$ 8L/GL/XVTSa$ ETLWc3/5W.SM4GETL
]E.]TSMEWEiEWS1 GVLS1 LVES1iEVNEW5-.VEWLTEM +STR S1NXW5NS1 L-4
TSiST5WEiEWN$& 2$2.-C.c@V.-;LTW3-LM 8-S_83$ *$$)$ $$
!$##**c
-).!KLVSNP$ 9L1N.XVSL1 8$ [5/EVEFXWLTENTREWEiEWN.US1NXWS1$ L/5W.SM GETL4]V.TES1$ L1M
TREGETL4L/5W.SM ]VE-XVN.V]V.TES1 S1TVL-EWLVM./LS1 $& 2$2.-C.,
@V.-;LTW3-LM 8-S_83$*$$)$$$!%#&#*c
-&.!YSNNVS1F93$KLVSNP$.U
!
4L/5W.SM S1 3@@TVL1NFE1S-/S-E]VEiE1TN]WL`XEU.V/LTS.1
NE-.1MLV5]LTR.W.F5$ L1M ]VE/LTXVEMELTR-C.c;EXV.1$*$$)$&$
!##$(%c
-.!KLVSNP$ 9L1N.XVSL1 8$ AESNNVS1F93$ ETLWc@LVTSLWW.NN4.U
UX1-TS.1 /XTLTS.1NS1 S1NXWS14MEFVLMS1FE1[5/ETRLTS1MX-EMSLGE4
TENLWN.S/]LSVMEFVLMLTS.1 .UL/5W.SM GETL4]V.TES1 -C.c3/C
@LTR.W$ *$$&$#&! & #&*c
-#.!PL1FBK$ AS?AcYUE-T.UE1M.FE1.XN
!
4L/5W.SM .iEV]V.MX-4
TS.1 .1 TLX ]R.N]R.V5WLTS.1 S1 -EW-XWTXVE-C.cC;EXV.-RE/$
*$$#$7(!&##%c
-%.!
!¯¾
$
Cåú
$
=D¶
$
Ý
c
‹5a}~€žDŽhm
#§¨…cœ
-C.c
$%#Œ|Œ-.
$*$$&$*$ !7#
(#c
-(.!<..\ HJ$ AEiEVE1[CZ$ 9-9SWL1 @C$ ETLWc>EMX-EM RS]]4
.-L/]LWS1NXWS14MEFVLMS1FE1[5/ES1 WLTE4.1NET3W[RES/EVrNMSN4
ELNESNLNN.-SLTEM +STR TREL].WS].]V.TES1 Y4E& LWEWE-C.c3/C
@LTR.W$*$$)$#*!#))c
/##(*/
v
)(
Õv
%
x
*$)
q
7
r
!!!!!! ! ! ! ! ! !!!! ! ! ! !
.^Wc)($:NNXE!%
8E]TE/GEV$ *$)
*LL?SB@L=@AT/G@ X.ATA-@ ?LL?EP?IS?ABB-K/?B@A/?-EA.AT -AF,?,@ED @L
4>E-BI-AF?NJE?II.@A@L.AIG/.A+F?TE-F.AT ?AYD,?.AC.JJ@S-,JGI
B?3;JQS140SE
$*
$ H3:QXL1
*
$ ?_Q.1F
$*
$ 93QX14T.1F
$*
$ D_8RS40X1
$*
!
$ P3;JQ.1F45L1
)
!c4()*(?-<#,-.8$5(#& !?.2$&$#)E-7F#C.?#*.?7.87,*-3#*$K-,-#?5 #&0 1-2-).%3-&*.
@?#0$*$.&#)45$&-,-/-0$$&#)K-,.(?-,.8$5(#& !?.2$&-$ 45-&:0( #)%$ 45$&#,
*c45-&:0( ;&$2-?,$*7.@?#0$*$.&#)45$&-,-/-0$$&-$ 45-&:0( #)%$ 45$&#,
)c45$&# 6#0-37.@?#0$*$.&#)45$&-,-/-0$$&-$ <-$=$&: $$%$$$ 45$&#
-4KIBE-SB.!6K[?SB.P?# I.NTXM5TREEUE-T.UI.1FWX.DS1F1L.EUEViEN-E1TTLGWET.1 WELV1S1FL1M /E/.V5.UME/E1TSLVLTNS14
MX-EM G5S10E-TS.1 .U3
!
*4)
S1 RS]].-L/]XNL1M E6]VENNS.1 .US1NXWS14MEFVLMS1FE1[5/ES1 RS]].-L/]XN$ S1 .VMEVT.]V.iSMEGLNSNU.V
]VEiE1TS1FL1M TVELTS1FNE1SWEME/E1TSLc!
*4)
S1 RS]].-L/]XNcIREVLTN
+EVEMSiSMEM S1T.TRE/.MEW-.1TV.WFV.X]$ TRE3VS-E]T!c& /F/\F
e
FV.X]$ L1M I.1FWX.DS1F1L.EUEViEN-E1TTLGWETRSFR M.NE
!%c# F/\F
e
$/SMMWEM.NE!)c%( F/\F
e
L1M W.+M.NE!c7 F/\F
e
FV.X]Nc3NRL/.]EVLTS.1 FV.X] +LNENTLGWSNREM G5S14
0E-TS1F1.V/LWNLWS1ES1 RS]].-L/]XNcIREVLTN+EVE.VLW5FSiE1 MVXFNU.V7$ ML5N$ .1-ELML5cIRESVWELV1S1FL1M /E/.V5+EVETENTEM
G5XNS1F9.VSN+LTEV/L[Ec://X1.RSNT.-RE/SNTV5L1M S/LFEL1LW5NSN+EVEXTSWS[EM U.VL` XL1TSTLTSiEL1LW5NSN.1 TREE6]VENNS.1 .US14
NXWS14MEFVLMS1FE1[5/ES1 RS]].-L/]XNc8?IG/B# I.1FWX.DS1F1L.EUEViEN-E1TTLGWET-.XWM NSF1SUS-L1TW5NR.VTE1 TREEN-L]EWLTE1-5.U
VLTNS1 TREMSVE-TS.1LW1LiSFLTS.1 TENT$ ]V.W.1FTREVETE1TS.1 TS/ES1 TREUSVNT` XLMVL1TM+EW$ ME-VELNETREVETE1TS.1 TS/ES1 TRETRSVM
`XLMVL1TM+EW$ S1-VELNETREUVE`XE1-5.U-V.NNS1FTRE]WLTU.V/$ NR.+L/.VE1.TLGWENTLTSNTS-LWNSF1SUS-L1-ETRL1 TRE/.MEW-.1TV.W
FV.X]!!u$c$c3MMSTS.1LW5$ ST-.XWM LWN.VE/LV\LGW5S1-VELNETRELiEVLFE.]TS-LWME1NST5.US1NXWS14MEFVLMS1FE1[5/ES1 RS]].-L/4
]XN$ ]V./.TETREE6]VENNS.1 .US1NXWS14MEFVLMS1FE1[5/ES1 RS]].-L/]XN$ L1M NR.+L/.VE1.TLGWENTLTSNTS-LWNSF1SUS-L1-ETRL1 TRE
/.MEW-.1TV.WFV.X]!!u$c$c0@AS/GI.@A# I.1FWX.DS1F1L.EUEViEN-E1TTLGWETRLNTREEUE-TN.US/]V.iS1FWELV1S1FL1M /E/.V5
-L]L-ST5.U3HVLTNL1M ]V./.TS1FTREE6]VENNS.1 .US1NXWS14MEFVLMS1FE1[5/ES1 RS]].-L/]XNc:TNEUE-TS1 ]V./.TS1FS1TEWSFE1-E+SW
GEVEWLTEM T.S1-VELNEM S1NXWS14MEFVLMS1FE1[5/ES1 RS]].-L/]XNc
- ?`D R@EFI.!I.1FWX.DS1F1L.EUEViEN-E1TTLGWET, WELV1S1FL1M /E/.V5, RS]].-L/]XN, S1NXWS14MEFVLMS1FE1[5/E
F@.#)a_(bOS[S,,()&%(&

tu-0
!
|}}
#
/%#(*/
v
)(
Õv
%
x
*$)
q
7
r
!!!!!! ! ! ! ! ! !!!! ! ! ! !
.^Wc)($:NNXE!%
8E]TE/GEV$ *$)