免费文献传递   相关文献

Liposoluble constituents from Iodes cirrhosa and their neuroprotective and potassium channel-blocking activity

微花藤脂溶性化学成分及其神经保护与钾通道阻断活性



全 文 :#|}
#
Z—›vœ^_Ú6GªÍAži
Ÿm ¡‘‡
£¤Ä
R#X
#
A
R
#
Eœy
R
#
¥¦§
R
#
¨.©
R
#
<Ùª
R
#
\«z
R
#
.y
R
#
.%º
R
#
ÔÕ
R
!
!Rb
58E¬F¬G #õCDE¬G HåIJK 5EHå@FGñHÃ?I
è(éwêëìí
#

RMMMLM%
Xb
58E¬F¬G #õCDE¬G EHAåòóIJK
#

RMMMLM
$
ƒ;
%!

&
ƒ„Z—›
S#$1/:,4&#/0
[^_Ú6
!
>C6š^ÄÌ>Ëã̇•¶

œ
,
®“‘¢}zùÓ>Ë
6šö^
!
>m Tôrz_ÕÔª01

m £Só[…©Ç¿
9?DQ
MG±²•IÜâC^ÄÌ[Í±²Až‡>
ËUV

®“DZGÑ±GŸm R/ە¶ÜâC^ÄÌ[Ÿm R/‡>ËUV

žŸ
,
³Z—›ì
`Lh

µ$Ì[~B~Us$Ø66šS
XR
^ÄÌ
!
6šÕÔê
R
#
!Q
#
<
ý¨sj݄
<`$!!%!RX<
ýØ
$!%#
[ª¡~BU
$#%#
Q
#
<
×9vE¡èhBU
$$%#Q
#
<
~°†s
<

Ø
E
$%%#
vivB
$&%#
Íj¡
$%##
<
¨sÍj¡
$(%#
Íj¡

#
>
.<
]^äåoà
$)%#
ükl~U
$*%#
üklà
$!+%#;<
®¯°‘Q
$!!%#
GÈB²U
$!#%#
GÈB
$!$%#X!Y<
ý²†s
<
R!_<
Ϥ
$!%%#
ÈYm³
$!&%#
×^³
$!%#
ÈYmB
$!(%#
×^B
$!)%#
®¯B
$!*%#
nýB
$#+%
Ñ6ýB
$#!%
]
R v
RM
SY
I/&-C
SR
>(9
!
^ÄÌ
$!%!!*!!+!!%!!&!!)!#+
C£Só¾
1.<1dLd<9?DQ
±²[…•IAžz6aê
R\\h!
R__h!RQ\h!RQ\h!R_Qh!R_Lh!RQ\h!RN`h
Ñ
RQMh
^ÄÌ
!
]
R vRM
SL
I/&-C
SR
>(9]
X
¢Ÿm R/ە¶Ü
â_ŒÍoK<(Ç<

ž 
,
^ÄÌ
!
ê‹^ÄÌ

²è^Ä̌êp5³—›CÉÌr€T

^ÄÌ
$!%!!*!!+!!%!
!&!!)!#+
CÍ±²y腕IAžE“

^ÄÌ
!
yèŸm ¡‘‡

$
„…†
%!
Z—›
&
mcdø
&
^_Ú6
&
Ÿm ¡‘‡
$
8‡$f
%!XMRMRXMXMR_
$
ˆ‰Eq
%!
­ænëø_stuv
$QMNXLM__!XM_QXMQM%&
­æ
k-s¨ƒ„€?
$`\Q%
/3
$XMM_7RQLRN`MY!XMMY7LM_\MR%&
_ŽØz5_FÑH‹pß%/3
$;3AMLR_%
$
Š>‹
%!
!
ÅÇà
!
_`
!
‚&³ÙÇÌ^_ƒ„
!A(&,$MRM%
NQRL_\N`!-!!
Z—›
S#$1/:,4&#/0 A4%Geb
êmcdø
;G$G<
)$G($(
Z—›C
S#$1/
ÉÌ
!
ò[›£
!
ÆMNqr
›
!
—á›

6V•ò­7*
#
8þþØÑüþ؏
Güþ`|Ã
R(

Z—›[ìê7*ϒ“Ç
!
y
èh?×À
!
•FmB[àé
!
“;úû?ÀF
!
JZ
!

!
s³ø>
!
?I‡ùÆ
X(

Z—›CÉ
Ì{è
R`
¢
!
6V•½Ã`tGÇt
!
ò­ä
_
¢
R(

EFCjn7*Ïb[Z—›
$SL:,4&#/0
A4%Geb%
>ˈqHå[^_Ú6ƒ„

h7
Q<_(
2
 ˆ³Z—›
`Lh
~¡µ$Ì~B~Us$¾[
(œØ6S[†‹òvûª‹^ÄÌ

£72
 ³~B~Us$Ø66šS[
R
‹^ÄÌ
$
f
R%
Ѫé
XM
Ñï^ÄÌ[6š
#
01ÕÔi
‡•¶0Œ

]C^ÄÌ>˝ÍAž‡[•
¶r
!
]
R vRM
SY
I/&-C
SR
>(9
!
^ÄÌ
$!%!!*!
!+!!%!!&!!)
Ñ
#+
C£Só¾
9?DQ
MG±Íl
±²Æ±²
$1.<1dLd<9?DQ%
‰Ô¼m–yèw£
[AžE“

^ÄÌ
!
]
R vRM
SL
I/&-C
SR

KŸm ¡‘‡

f
R!
^ÄÌ
!
[
R
.<
R
.O1d$
(p
%
i
‰Š[
.=7$.
#
%

-QNRR-
{
QY
ï{
`
—
XMRR
÷
L
´
!!!!!! ! ! ! ! ! !!!! ! ! ! !
U/&bQY! ;004(!`
=$B! XMRR
!!
^ÄÌ
!
êv};ƒ
!;3
Kzw½K¨s
$Q
QR\ GI
SR
%
ÑÐu܊
$R YQX!R YRM GI
SR
%
[±¯
IJÐ
&-1;<=1
ÝK,6mšm
*VK_YQ =c
?$(
c
!.3-1;<=1 *VK__RbQ\M ` =c.(
c
櫦
6mšê

QM
.
_N
O
X
$G$&G5 __RbQ\X \%!
YvÑ(ê
^ÄÌ
!
[
R
.zOP)ÝK
X
jÿ¥
Ä[܊[mnf!
YbLX$R.!5!2ZYbM .e!.Ñ
Lb_\$R.!5!2ZYbM .e!.S†5²s
[mnf!
QbNY$R.!55!2ZRXbM!_bM .e!.Ñ
QbQX$R.!55!2ZRXbM!_bM .e!.]âP)
!
w
½
N
²s[mnf !
, RbXY $Q.!0!..$Q.!0!.Z9
]!
RbML jXbM_
w½Ø6kÜ[‘`²sÑ
$
L
%
5²s[m[‘kÐnf

^ÄÌ
!
[
RQ
<
?=3
ÝK
QM
‰nf
!T-8A
zw½¥¦‰nf6

N
²s‰
#N
5²s‰
$
ªr
X
ê
0V
X
¥

%#w‰
$
wx
X

0V
X
¥^‰
!L

0V
Q
¥^
‰
%
Ñ
`²s‰nf


R
.
Ñ
RQ
z(
)i7«2 
L(
[j݄â„Ú
R!Q
#
<5#B5%/KB4%0<
`$RR%!RX<5()([rz()Ç;j
Å
!
ýF[)a]•
!
^ÄÌ
!
[
R
.zr
.†âPI`%!
RbXX&
®
!
]^ÄÌ
!
[
R
.
Ñ
RQ
<
?=3
zr
!
Œw½z`vx°s[nf
!
µ½^
ÄÌ
!
*iñ7«
L(
2 ^ÄÌ[£vx°sF
ãÌ

^ÄÌ
!
[01m 
XT¦§ªÙ



.1g
¦§fz6C
?=3
zr›ƒ
jS[‰Ñ[mnf>ˈ,/:C


R
.<
R
.
O1d
zrj‰nf[‚
!
/ƈª[mg’j
ÿ¥Ä[01t™
$
üf
R
r(p²½
% .=7
zr
!i
.
!X_

!
0Ä¥¦[mщ[^_I`
!
/Æ=¨
s6aSƒ]
_

®
!.i

!.j
‰
!
Æ.=ÜŠ6aI•
<`$Ñ
_
$
f
R%
^ÄÌ
!
[
.Ñ
.[­6~šÑ¥Ä;(
Œi7«r
R
#
!Q
#
<5#B5%/KB4%0<`$RR%!RX<5()(2$5(G$)/$2(
[ŸOjZ
!
i,/Ôù¼
Ñ
[
1âjZ

,
!
^ÄÌ
!
[01/Ôê
R
#
!Q
#
<
ý¨
sj݄
<`$RR%! RX<
ýØ
R
#
! Q
#
<5#B5%/KB4%0<`
$RR%!RX<5()((
!!
ÁÂ
8(%W)<-&I(%Q_Q
?Kß
&U$%$) ;)/E$_MM
L
LMM =.e
+зß&Ô
$
œÛÐê~À
%&=<
G%/I$00>42/0V(G<,&2I$-AOJ
L
>GG4A/J1 9=1<
9RMM1
[zß
&;1OG/IPJ&$0#
ÙÄyš}zß
&
>*&()2.8RXMM
â â é ˜ j } z ß
! 3V
RN
}z—
$RM IIvXLM II!L
!
I%&
—}z’“GT
4}z’“
$
ªÌö^Nå
%& 1(V#$5(KC.$8#$%I$G$
˜%
%
Z—›ÇÁjn7*Ïb
!
Í
7*´*|3qK§N#•ÕÔêZ—›
Sb:,4>
4&#/0 !
ÉÌÀ£
$?/bd@MXMRR%
Žè•Ç̃„²
ÉÌÀ£z

# !
µ$6š
ºÃZ—›ì
YbR W*!
Í
`Lh
~¡ŸÛµ$
Q
5
!
85
Q #!
µ$˜ÍOÊJœÛšû
Y_M *
šû6ו
_ C
(r
!
“~B~Us$
$_ Cv_%!

S~B~UÑ(j
X
Ø6

~B~UØ6
$RLL *%
>˒“—}z6š
!
ÅÓÙ
<
~B~U
$LMwR jYMw
_M%#
~B~U
<
²¡
$XMwR jMwR%
ù(n”
!
n”˜
ÍT4}z¸&
!
Ä>ÙÚjœ¸S
`
n”
Ø6
$>j;% >$
ÅÓÙ
<
~B~U
LMwR%
Ø6K
v};ƒ
!
“;ƒÍ
1(V#$5(KC.—}z
$
ÅÓ
Ù
<
r{
<
²¡
LwLwR

!
¬Q?.n”œÛ
9Œ“,n”Hå
%
ö^^ÄÌ
#$XYM I*% 7
$
ÅÓÙ
<
~B~U
LMwR%
Ñ
T$
ÅÓÙ
<
~B~U
XMwR%
Ø6r6aK0n
!
ÍÅÓÙ
<
‘Ek0n
6aS^ÄÌ
$$RXM I*%
Ñ
%$Q_M I*% -$
ÅÓ
Ù
<
~B~U
_wR%
Ø6
$RbX *%
Í
1(V#$5(KC.—}zxl6šö^^ÄÌ
& $XY I*%
Ñ
$QL
I*% J$
ÅÓÙ
<
~B~U
Yw_%
Ø6rÚ¾Kä
O}Ñ-}-í0n
!
͑Ek0n6aS^Ä
Ì
*$_YM I*%
Ñ
#!$LX I*%&J
n¾[l˜Ø6
$XbY *%
Í
1(V#$5(KC.—}zxlö^
!
Ø͒
“—
$
ÅÓÙ
<
‘E
`wR

%
}z6šS^ÄÌ
($QL I*%!*$YL I*%!!%$Y I*%!!&$XY I*%!!$`
I*%!!($N I*%!!)$XX I*%!!*$L I*% @$
~B~
U
<
²¡
XMwR!_L *%
Ø6͒“—}z
!
r{
<
²¡
$RMMwR jYwR%
ù(n”
!AC
¸&Ä>jœ¸
S
Y
`Ù¸
$@
R
j@
Y
% @
X
$
r{
<
²¡
LMwR

Ø6
!RbQ *%
i
@
Q
$
r{
<
²¡
XLwR
nӯ6
!Lb*%
`Ù¸6aÍ
1(V#$5(KC.—
$
r{
<
²¡
RwR

%
}zxlö^
!
6aS^ÄÌ
!$\ I*%!)
-_NRR-
{
QY
ï{
`
—
XMRR
÷
L
´
!!!!!! ! ! ! ! ! !!!! ! ! ! !
U/&bQY! ;004(!`
=$B! XMRR
$LX I*%!#+$_Y I*%&@
_
$
r{
<
²¡
RLwR
nӯ
6
!XbY *%
`Ù¸Íxj
J&$0#
—}z
$M j_Lh

( œ ˜ ù ( n ”
%# 1(V#$5(K C.—
$
r{
<
²¡
RwR%
}zÑxj
.8C
ÜÝ}z
$
²
¡
<
(
_MwYM%
6šS
!!$RX I*%!!#$QL I*%!!$
$X\ I*% .$
r{
<
²¡
`wR%
n”Ø6KäO}
0n
!
Ͳ¡k0nS^ÄÌ
!+$QLM I*%
$!
^ÄÌ01ÕÔ
^ÄÌ
!!
v};ƒ
&
+
(
XM
.
cYXbLy$GMbLM!
$G(2/)(%&;3
,
I$K
Q QR\!X `X_!R YQX!R YRM!R LRN!
R _L`!R Q\Y!R XYR!`NN!NMQ GI
SR
&$ c%<-1;<=1 *V
K_YQ =c?$(
c
!_\` =cD(
c
&.3-1;<=1 *VK
__RbQ\M ` =c.(
c
$G$&G5
QM
.
_`
O
X
6/%__RbQ\X
\%&
R
.Q
!LMM =.e%
!
,QbNY$R.!55!2Z
RXbM!_bM .e!._bM .e!.QbQX$R.!55!2ZRXbM!_bM .e!.2Z\bM!.YP%!RbYY$R.!I!.<\$%!RbQ`$R.!I!.<\P%!YbLX
$R.!5!2ZYbM .e!..$R.!I!.RY$%!Mb`Q $R.!I!.RbQM $ R.!I!.$R.!I!..RbXY$R.!0!...RQ
Q
!RXL
=.e%
!
, \YbM $$<_%!_NbN$N%!RLXbQ$<`%!__bN$$XNbQ $R`%!Q`bR $$R\b` $QM%
^ÄÌ
#!
v}-n
&-;<=1 *VK_YN$=
c-
%&
R
.Q
! LMM =.e%
!
, _bLX $ R.! 55!2Z
RRbM!_bM .e!.0!.Mb``$Q.!0!..2ZYbM .e!.Q
%&
RQ
$T&
Q
!RXL =.e%
!
, QYbL$$$<\%!R_LbL$$XNb` $RN%!QLbQ $$XQb\ $X`%!XQbL$Q
%!R\RbM$O.
Q
%
_¢()i7«
Y(
2 [[ª¡~BU
$P$4(%()<
B&$G(2$2(%
()|Ë

^ÄÌ
$!
v}-n
&;3
,
I$K
X `XM! X NLR!
R \QR!R YLR!R YRN!R _Y\!R QN\!R QYX!R XRR!R R`\!
`N_!N\N!\XR GI
SR
&-;<=1 *VKY\N$=
c-
%&
R
.$T&
Q
!LMM =.e%
!
, Xb\` $R.! 52!2ZRQbL!QbL
.e!.$
%!_bLX
$R.!55!2ZRXbM!LbM .e!.RRbM .e!.RX%!RbQL!RbR`!RbRQ!Mb`M!MbN`!MbNN!MbN\!MbNY
$($G# Q.!0!.QR.! P%0! $.
X
%
R_
.
Q
(&
RQ
Q
! RXL
=.e%
!
, QNbN $$<_%!LLbM$N%!YRb\ $<`%!Q\bM $$XYbL $R`%!QRbM $$XQb_$OO<%!XXb` jX`b\<$.
X
%
R_
.
Q
(!R_bR<$.
X
%
R_
.
Q
(
_¢()i7«
\(
2 [
Q
#
<
×9vE¡
èhBU
$ Q
#
<#B5%/KB2$2(%
()|Ë

^ÄÌ
%!
v}-n
&;3
,
I$K
X `LN! X `XL!
R \QR!R YLR!R YR`!R _L_!R QNN!R X_Q R MX_!`N_
GI
SR
&-;<=1 *VK_NX $=
c-
%&
R
.Q
!LMM
=.e%
!
, Xb\L$R.!52!2ZRQbL!QbL .e!.$R.!25!2ZRQbL!LbM .e!.55!2ZRXbM!_bL .e!.-LNRR-
{
QY
ï{
`
—
XMRR
÷
L
´
!!!!!! ! ! ! ! ! !!!! ! ! ! !
U/&bQY! ;004(!`
=$B! XMRR
$R.!0!.$($G# Q.!0!.2ZYbL .e!.0!O.
Q
%&
RQ
Q
!RXL =.e%
!
, QNb`$<
R%!XQbY$R\bL$QYbN$RQ%!_QbY $$QMb` $X_%!RYbL $$Q
%!
R\RbM$O.
Q
%
_¢()i7«
N(
2 [
Q
#
<
~
°†s
<

Ø
E
$Q
#
<$G(2/KB<4%0/)(%
()|Ë

^ÄÌ
&!
v}0n
&;3
,
I$K
Q LNY! Q _LM!
X `_M!R YNL!R Y_X!R _LR!RXQ _!R M_X!NYX GI
SR
&
-;<=1 *VK_LY$=
c-
%&
R
.Q
OT!LMM =.e%
!
, QbMY$R.!55!2ZRRbL!LbM .e!.555!2ZRMbL!RMbL!LbL .e!.XQ%!MbY` $Q.!0!.Mb`L$Q.!0!.$($G#!R.!P%0!.
X
RQ
$T
Q
OT!RXL =.e%
!
, Q`b`$$\%!_Rb` $RR%!XYb` $$LMb_$XX%!XNbY $RRMbR$_¢()i7«
`(
2 [viv
B
$P(24&)G$G5%
()|Ë

^ÄÌ
!
v}-í0n
&-;<=1 *VK_RX
$=
cb
%!Q`\!QY`!QLR!QMM!X\R!XLL!XX`!XRQ!NQ!
LL&
R
.Q
OT
Q
!LMM =.e%
!
, QbQN$R.!I!
...$R.!55!2ZRLbM!\bL .e!.YbL .e!.$Q.!2!2ZYbM .e!.RQ
Q
OT
Q
!RXL
=.e%
!
, QNb_ $$<_%!R_XbY$$X`bM $R`%!_RbQ$$XRb\$_¢()
i7«
RM(
2 [Íj¡
$02*I$02$#
<
/&%
()|Ë

^ÄÌ
(!
v}0n
&-;<=1 *VK_XN$=
c-
%&
R
.Q
!LMM =.e%
!
, QbLL $R.!I!.LbX`$R.!P%0!.Mb\R$Q.!0!.2ZYbL .e!..$Y.!5!2Z\bL .e!..e!.RQ
Q
!RXL =.e%
!
, QYb`$<
R%!QRbN $L%!RXLb_ $`%!QYb_$RQ%!LLbQ $$XRbR$X_%!QRbN $$_¢()i7«
RR(
2 [
#
<
¨sÍj¡
$#
<#B5%/KB02*I$02(%/&%
()|Ë

^ÄÌ
)!
v};ƒ
& $ c%<-1;<=1 *VKL`=c?$(
c
&
R
.Y
!_MM =.e%
!
, Qb_Y
$R.!I!.$Q.!0!.YbN .e!.XX%!LbMR $R.! 55!2ZRYbM!_bN .e!.$Q.!5!2ZYbM .e!..2ZNbM .e!.QbYQ$R.!55!2ZRMb_!LbY .e!.I!.RQ
Y
!RMM =.e%
!
, Q\bL
$$$<`%!QYb`$$-YNRR-
{
QY
ï{
`
—
XMRR
÷
L
´
!!!!!! ! ! ! ! ! !!!! ! ! ! !
U/&bQY! ;004(!`
=$B! XMRR
LYb` $XM%!XRbY$$XLbY$Xi%!\\bL$Yi%
_()i7«
RM(
2 [Íj¡

#
>.<
]^äåoà
$02*I$02$#

#
>.<
*&4G/VB%$)/05(%
()|Ë

^ÄÌ
*!
äO}-í0n
&-;<=1 *VKR`X
$=
c-
%.&
R
.Q
OT
Q
!LMM =.e%
!
, YbRY
$R.!5!2Z`bL .e!._%!Yb\N$R.!0!.O=(%&
RQ
Q
OT
Q
!RXL =.e%
!
, RYRbX$<
X%!RRQbQ$Y%!RLRb\$<\%!RMQbN$RM%!LYb\$O=(%
_()i7«
RX(
2 [ük
l~U
$0G/V/&(2)%
()|Ë

^ÄÌ
!+!
äO};ƒ
&J>7<=1 *VKQ\=c?$(
c-
&
R
.Y
!LMM =.e%
!
, YbQX
$R.!5!2Z`bL .e!._%!\bRL$R.!0!.O=(%! LbM\ $ R.! 5!2Z\bL .e!.RQ
$T=1O<$
Y
!RXL =.e%
!
, RYMbL$R__bX$<_%!RM`b\ $\%!RMQbM $$O=(%!``bY$$<_i%!\\bR$_()i7«
RQ(
2 [üklà
$0G/V/&)%
()|Ë

^ÄÌ
!!!
-}ùÿ
&;3
,
I$K
Q _MM!R \R`!
R Y_`!R LN`!R LRQ!R __X!R XYR!R RR_!`\L!NRQ
GI
SR
&$ c%<-1;<=1 *VKQYM =c.(
c
!QNX =c
?$(
c
!$ S%<-1;<=1 *VKQLN = S.(
S
&
R
.$T
Q
OT!LMM =.e%
!
, Yb`Q $R.!5!2ZXbM .e!.<
X%!YbY`$R.!5!2ZNbM .e!.NbM!XbM .e!.YbQL$R.!5!2ZRLbL .e!.<\%!YbYQ$R.!5!2ZXbM
.e!.55!2ZNbM!XbM .e!.LbL .e!.<\i$%!XbN_$R.!55!2ZR_bM!NbM .e!.<\i
P%!_bY_ $R.!55!2ZNbM!LbL .e!.RQ
$T
Q
OT!RXL =.e%
!
, RX`b` $R_Yb\$Y%!R_XbN $<\%!RRYbM $$RR\b_$Ni%!RY`bM$<`i%
_()i7«
R_(
2 [
;<
®¯°‘Q
$G&/E$I5(%
()|Ë

^ÄÌ
!#!
O};ƒ
&;3
,
I$K
Q QL`!R YNY!
R YX`!R YMR!R LRY!R __Q!R XYN!R R\N!R RYM!R RR_!
`\N!NRX GI
SR
&$ c%<-1;<=1 *VKLLQ =c?$(
c
!
LY`=cD(
c
! $ S%<-1;<=1 *VKLX` =S.(
S
&
R
.Y
!LMM =.e%
!
, XbR\ $X.!I!.<
X%!LbRL$R.!555!2Z` bL!QbM!QbM .e!.$R.!55!2ZLbL!QbM .e!.<_%!LbML$R.!I!.Rb`Y$X.!I!.$R.!5!2ZNbM .e!..e!.$R.!5!2ZRYbM .e!..2ZRYbM .e!.RQ
$T=1O<$
Y
!RXL =.e%
!
, \Xb_ $\MbN$R\Qb\$<\%!RXLbQ$Qi%! R_NbQ $<_i%! RRLbN $R_LbL$<\i%!RRQbY$R{%! RR_b\ $RRLbN$N{%!RYYbM$<`{%!LRb` $O=(%
_()i7«
RL(
2 [GÈB²U
$I(2#B&Q!L<5<@6(/B&^4)$2(%
()|Ë

^ÄÌ
!$!
O};ƒ
&;3
,
I$K
Q Q_N!R YNY!
R YQM!R YMX!R LRN!R __L!R XYR!R R\N!R RR\!`\N
GI
SR
&$ c% S-1;<=1 *VKLQ`=c?$(
c
!LLL=c
D(
c
! $ S%<-1;<=1 *VKLRL =S.(
S
&
R
.$T
Q
OT!LMM =.e%
!
, XbRY$X.!I!.I!.$R.!I!.Y$%!XbM` $R.!I!.Yb\Q$X.!5!2ZNbM .e!.NbM!XbM .e!.YbXR$R.!5!2ZRYbM .e!.NbM!XbM .e!.YbXN$R.!5!2ZRYbM .e!.RQ
Q
OT!
RXL =.e%
!
, \_b` $-\NRR-
{
QY
ï{
`
—
XMRR
÷
L
´
!!!!!! ! ! ! ! ! !!!! ! ! ! !
U/&bQY! ;004(!`
=$B! XMRR
\MbN$<_%!\XbR $RX\b`$_i%! RRLbY $RRLbR$X{%! R_\bM $RXQbM$`{%
_()i7«
RY(
2 [GÈB
$Q!L<
5G$6(/B&^4)G$G5%
()|Ë

ªé^ÄÌ¥)ª
;3!=1!
R
.Ñ
RQ
()6aÕÔê
X!Y<
ý²†s
Ϥ
$X!Y<5I(<
2#/KBR\(
!
ÈYm³
$V%/2/G$2(<
G#4$&5(#B5(!!&%
RN(
!
×^³
$E$)&)!!%
R`(
!
ÈY
mB
$ V%/2/G$2(G#4G$G5!!(%
RN(
!
×^B
$E$)&G
$G5!!)%
XM(
!
®¯B
$G$6(G$G5!R`%
XR(
!
nýB
$$e(&$G$G5!#+%
XX(
!
6ýB
$04GG)G$G5!#!%
XQ(
()|Ë

%!
‡•¶
%[!!
ÍAž‡
!
®“
1.<1dLd<9?DQ
‰ÔMG
±²–
!
m £Só[…©Ç¿
9?DQ
MGÍl±
²Æ±²
$1.<1dLd<9?DQ%
[•IÜâ
!
C^ÄÌ
! #`+
>ˇ•¶

]
R vRM
SY
I/&-C
SR
>(9
!
^ÄÌ
$!%!!*!!+!!%!!&!!)!#+
C£Só¾
1.<
1dLd<9?DQ
‰Ô¼m–yèAžE“
!
…•IAžz
6aê
R\\h! R__h! RQ\h! RQ\h! R_Qh! R_Lh!
RQ\h!RN`h
Ñ
RQMh$Q
5¦§)Œa
!qMbML%
%[#!
Ÿm ¡‘‡
!
\“DZGÑ±GŸ
m R/Ûâm·•¶Üâ
X_(
!
m &Ô
T7>
_
$Q%
oK<([F^;x®±²·/I[F^
!
³
h’ƒx®^ÄÌCDZGŸm G±GŸm
 [E“

]
R vRM
SL
I/&-C
SR
>(¬
!
^ÄÌ
!
*ÍoK<(Çâ
!
¼Têt
!
*i衑Ÿm 
[E“
!
>|Z\“±GŸm R/ە¶Üâ
>褮
!
Æ.
!
/¦yè|Ô¡‘Ÿm E“
$
¼
R%
¼
R!
^ÄÌ
!
CŸm [E“
^ÄÌ
DZGŸm R/ÛÜâ ±GŸm R/ÛÜ
¶Q>(
[I/&-C
SR
±²·
/IF^
¶Q>(
[I/&-C
SR
±²·
/IF^
RY
R vRM
SL
RQR vRM
SL
RMr^Ÿ L vRM
SX
RQL vRM
SX
NQ
˜~{ R vRM
SX
RMY
R vRM
SX
RMQ
$
Ž‘
%
R (!
…7÷
:
r­É̦
:
{
_Y
ï
=(:
úû
,
ø_KĎ
!
R`NR, L_b
X (!
­ær¦Çè¤3rΣ^W}æ
:
rΣ^
:
{
RQ
ï
=(:
_
,
_ø_ùÓKĎ
!R```, XX\b
Q (!@$) =C!f#$)*dC!C) 1!(2$&:@&BG/05(06%/I2#(%//2/6S#>
$1/:,4&#/09(:9?$28%/5!XMMN!\R$_%, Y_\b
_ (!
ø½¢
!
 |ì
!
¹ƒm
!
‡
:
Z—›~¡µ$Ì(œØI
[^_Ú6
9(:
r­rÇ¥¦
!XMRM!QL$_%, _LYb
L (!d$)*fT!@$/D!9$f9:-45(0I$)(5(%E$2E(0$)5 /2#(%G/)<
0224()206%/I+0)/)410 %04?,3(#409(:8#B2/G#(I02%B!XMMQ!YX
$N%, RR`Lb
Y (!#$W%$E$%2B>D!T$07!=$045$D!(2$&:8(%$G5 )54G(5 /K5$<
2E(%($%$)*(I()20/62%2(%V()/50, V%/54G20/6)(F0W(&(2/)
6%/IP$4(%()B&$G(2$2(9(:A(2%$#(5%/)!R``N!L_$XX%, YMYLb
\ (!7$%(%/0=C!T$E5 9=!8(%(%$8>5 8!(2$&:J$2B$G5 (02(%0
/62%2(%V()(06%/I<4!&4#=()*%0/14,-)*9(:97%$e#(I
1/G!XMMX!RQ$L%, YY`b
N ( !f#$)*gd!f#$/dd!#()*A=!(2$&:>)(F2%2(%V()/5
6%/I +!1(*0!#:4%!#- O&0/,0-)*9(:9>0$) ?$28%/5 3(0!
XMMM!X, NRb
` (!155^41!.$6((eJ!7(*4I1!(2$&:O&($)5(%/&!$)(FV()2$GB<
G&G2%2(%V()(6%/I2#(&($E(0/6;14,)*#(10-$149(:9?$2
8%/5!R`NN!LR$X%, XX`b
RM(!D/HI$.!1$2/?!.$2$)/>!(2$&:12(%/&*&4G/05(06%/I4)-1(>
(0 ?)(F04,/9(:8#B2/G#(I02%B!R``M!X`$\%, XQLRb
RR(!>G#()P$G# .!7()%0G#W(@:9/$))(0$&$G2/)($)5 /2#(%G/I<
V/4)506%/I2#0--1/,0 %4,-:1%/9(:8#B2/G#(I02%B!R``\!_L
$R%, R_`b
RX(!D$B0(%O!D/&/5e(H.:.*#&B/KB*()$2(5 G/4I$%)06%/I1(04>
F#-,)*/,$#,$1/9(:8#B2/G#(I02%B!R``L!Q`$L%, RRNRb
RQ(!A04W$I/2/.!.5$5$1!?0#P(1:/4I$%) $)5 0(G/%5/5
*&4G/05(06%/I P$%W /6@(10 034,:0-0 $)5 @(10 :0%1-/,/9(:
#(I8#$%I74&!R`NL!QQ$R%, Q`Yb
R_(!1$)P/)*!O0$W$P(?!?$204I(=!(2$&:>)2/K5$2E(V/&BV#(<
)/&00/&$2(5 6%/I6&1#B4#*0 :0:0#9(:9>*%GJ//5 #(I!
R``N!_Y$X%, _L_b
RL(!=$=!?$W$I4%$?!.$2/%=:;)#P2/%B(6(G20/) .;UV%/2($0(/62%<%$)5 %(&$2(5 >I5(09(:#(I8#$%I74&!XMMR!_`$\%, `RLb
RY(!a$&5 7!a%$BU!@$&()0$3!(2$&:=$&/)$2(5 6&$E/)/&*&BG/05(0
$)5 Q!L<5G$6(/B&^4)G$G5 6%/IV($%09(:8#B2/G#(I02%B!
R`N`!XN$X%, YYQb
R\(!
}5þ
b
h^ø}^C„¢r^Ç^_Ú6[ƒ„
T(b
ú
û
,
r­ÆѦø_
!R``L,_Xb
RN(!
7¢Î
!
7~¦
!
‚OU
!
‡
:
Jm[^_Ú6ƒ„
9(:

É̃„
!XMM_!XY$L%, LYQb
R`(!
±+ü
!
ªÜd
!
¼O
!
‡
:
8þ¹}^[^_^_Ú6ƒ„
9(:
:ëä̃„i™€
!XMMX!R_$Y%, Rb
XM(!
–ÇÎ
!
¼b
:
׀t\—[^_Ú6ƒ„
9(:
r­Ç_
-NNRR-
{
QY
ï{
`
—
XMRR
÷
L
´
!!!!!! ! ! ! ! ! !!!! ! ! ! !
U/&bQY! ;004(!`
=$B! XMRR
¥¦
!XMML!_M$RM%, \QQb
XR(!
¹
!
¹ˆ
!
Š‚U
:
_hƒ„^_Ú6[ƒ„
9(:
Ç_
_2
!XMML!_M$Y%, LX`b
XX(!/2$%G$C!T(&/*4 8!=$**/)8!(2$&:-6G()20B)2#(00/6

<64)G2/)$&e(5 )/)$)/G$G509(:1B)2#(00!R``\!$Q%, QXNb
XQ(!
¼…
!
ŠD9
!
7£Ž
!
‡
:
†Œ‡ˆ¤^_Ú6ƒ„
9(:
Ç
__2
!XMML!_M$Q%, XLXb
X_(!
&5•
!
4†Î
!
Š+B
:
Ÿm R/Û[âm·•¶Üâ
9(:
Ç__2
!XMM_!Q`$X%, NLb
;0MBKB1IN1AUBCKD0DIACDKLGB.7$2+03-11&$0 /CHDEA0GCAIGBMGBDAUD0RA
/CHMBD/KK0I.UE/CCA1-N1BUW0CV /UD0R0DF
@>?=$/&4/
R!X
! C;?1#()*! f.>?@d$)&)*
R
! f;9$G#()
R
!
1/)*a(K$
R
! .4 9)6()*
R
! #() ?$#/)*
R
! a$)*C)*
R
! a$)*+$/&$)*
R
! 1#9$)*/)*
R
!
$RbD150B#40!#4#3E,#0:!,?1+)B/!0-:1/0-$ M1/#)4:1/J!,(,K0!,#- #38&,-1/1914B0(H1$,:,-1! H,-,/!4#3<$):0!,#-!
S-/!,!)!1#3H0!14,0 H1$,:0! 8&,-1/1C:0$1*#3H1$,:0(+:,1-:1/0-$ 1O,-F J-,#- H1$,:0(8#(1F1! E1,7,-F RMMMLM!8&,-0&
XbS-/!,!)!1#3H1$,:,-0(E,#!1:&-#(#F! 8&,-1/1C:0$1*#3H1$,:0(+:,1-:1/0-$ 1O,-F J-,#- H1$,:0(
8#(1F1!E1,7,-F RMMMLM!8&,-0%
6NKDG/UD(8N_AUD0RA, A/0245B2#(G#(IG$&G/)0224()20/6S#$1/:,4&#/0 $)5 (E$&4$2(2#(%P/$G2E2Bb>ADEBH, A#(G/I<
V/4)50F(%(0/&$2(5 $)5 V4%6(5 PBE$%/40W)50/6G/&4I) G#%/I$2/*%$V#BI(2#/50$)5 2#(%02%4G24%(0F(%(5(2(%I)(5 PB0V(G2%/<
0G/VG5$2$$)$&B00b?(4%/V%/2(G2E($00$B$*$)020(%4I5(V%E$2/) )54G(5 1.<1dLd<9?DQ G(&$V/V2/00F$0(E$&4$2(5 PB=AA
I(2#/5 F#&(V/2$004IG#$))(&c
G#$))(&<%(*4&$2/%0G%(())*I/5(&0b
:AKI1D, AF()2BGV/%2/) /6$) (2#$)/&G(K2%$G2/62#(%//2/6SL:,4&#/0bA#(%02%4G24%(0
F(%((&4G5$2(5 $0R
#
!Q
#
<5#B5%/KB4%0<`$!!%!RX<5()($!%!P$4(%()B&$G(2$2($#%!Q
#
<#B5%/KBQ
#
<$G(2/KB<4%0#
<#B5%/KB02*I$02(%/&$(%!02*I$02$5()(#

#
>.<*&4G/VB%$)/05($)%!0G/V/&(2)$*%!0G/V/&)$!+%!G&/E$I5($!!%!I(2#B&Q!L<5<@G$6(/B&^4)G$G5$!$%!X!Y<5I(2#/KBE$)&G$G5$!)%!G$6(G$G5$!*%!$e(&$G$G5$#+%!$)5 04GG)G$G5$#!%b/IV/4)5 $!%!!*!!+!!%!!&!!) $)5 #+ 0#/F(5 )(4<
%/V%/2(G2E($G2E2(0$*$)020(%4I5(V%E$2/) )54G(5 1.<1dLd<9?DQ G(&$V/V2/00$2$G/)G()2%$2/) /6RbM vRM
SY
I/&-C
SR
F2#
%(&$2E(V%/2(G2/) %$2(0/6R\\h!R__h!RQ\h!RQ\h!R_Qh!R_Lh!RQ\h!RN`h!RQMh!%(0V(G2E&(Bb/IV/4)5 ! G/4&5 )<
G%($0(T7>
_
$$% 6&4/%(0G()G(%(0V/)0() P/2# )/)<0V(G6G$)5 0V(G6GD
c
G#$))(&<%(*4&$2/%0G%(())*I/5(&0$22#(G/)G()2%$2/)
/6RbM vRM
SL
I/&-C
SR
b2BCU1IK0BC, /IV/4)5 ! F$0$)(FG/IV/4)5 $)5 $&G/IV/4)50F(%(0/&$2(5 6%/I2#0*()406/%2#(6%02
2I(b/IV/4)50$!%!!*!!+!!%!!&!!) $)5 #+ 0#/F(5 )(4%/V%/2(G2E($G2E2(0F#&(! (K#P2(5 D
c
G#$))(& A^F TBGHK(!S#$1/:,4&#/0& ;G$G)$G($(& G#(IG$&G/)0224()20& )(4%/V%(G2E(& D
c
G#$))(&HB0,!+a%#)QU_U..#+!!+*!
$
’“$Q
!
—Z˜
%
-`NRR-
{
QY
ï{
`
—
XMRR
÷
L
´
!!!!!! ! ! ! ! ! !!!! ! ! ! !
U/&bQY! ;004(!`
=$B! XMRR