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作 者 ：汤湛,徐红燕,王俏

期 刊 ：中国中药杂志 2013年 38卷 13期 页码：2101.

关键词：川芎嗪；凝胶；薄荷油；月桂氮 NFDB3 酮；经皮渗透；

Keywords:tetramethlpyrazine, gel, peppermint oil, azone, transdermal,

摘 要 ：制备盐酸川芎嗪凝胶剂并研究其体外经皮渗透性。采用Valin-Chien双室渗透扩散池,以大鼠离体皮肤为渗透屏障,以HPLC测定川芎嗪含量,考察含药量、薄荷油、月桂氮 NFDB3 酮用量对盐酸川芎嗪凝胶剂经皮渗透性的影响。凝胶剂处方的最佳组合:5%月桂氮 NFDB3 酮+5%薄荷油+8%羧甲基纤维素钠+8%盐酸川芎嗪,12 h累积渗透量平均值为(6 731.87±102.31) μg·cm^-2,渗透速率平均值为(535.02±33.89) μg·cm^-2·h^-1,其体外经皮渗透近似零级过程。盐酸川芎嗪凝胶剂具有较好的经皮渗透特性,有望成为新的给药制剂。

Abstract:The purpose of this study was to prepare tetramethylpyrazine hydrochloride transdermal gel and to study its permeation ability in vitro. The skin permeation ability was evaluated by Valian-Chien permeation cells with isolated rat skin. The concentration of tetramethylpyrazine in samples was determined by HPLC. The optimal formulation was composed with 5% azone, 5% peppermint oil, 8% sodium carboxymethylcellulose and 8% tetramethylpyrazine hydrochloride. The accumulative permeation amount of the gel was (6 731.87±102.31) μg·cm^-2 in 12 h,and the permeation rate was (535.02±33.89) μg·cm^-2·h^-1. The release profile in vitro was in line with zero-order formulation. Tetramethylpyrazine hydrochloride gel prepared in the study would be developed as a novel transdermal preparation.

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