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作 者 ：富琦,唐勇,罗晓琴,杨国旺,何薇,王笑民

期 刊 ：中国中药杂志 2009年 34卷 12期 页码：1570.

关键词：鸡血藤；SSCE；抗肿瘤；机制；

Keywords:Spatholobus suberctus, SSCE, anti-tumor, mechanism,

摘 要 ：目的：研究鸡血藤提取物SSCE体内抗肿瘤作用及机制。方法：采用小鼠移植性Lewis肺癌模型，观察SSCE体内的抑瘤效应，抗转移作用，并通过检测细胞周期及细胞凋亡情况探讨其抑瘤作用机制。结果：低剂量SSCE对小鼠Lewis肺癌的抑制率最高，为28.6%，同时具有抗转移作用，作用细胞周期为G1期，凋亡率各组无显著性差异。结论：鸡血藤SSCE提取物具有直接抗肿瘤及抗转移作用，其作用周期为G1期。

Abstract:Objective: To observe the effect of anti-tumor and mechanism of the extract of Spatholobus suberctus (SSCE) in vivo. Method: The mouse model of Lewis lung carcinoma was used to investigate the effects of SSCE on tumor growth and metastasis. Furthermore, we explored the mechanism of anti-tumor by analyze the cell cycle and determine the apoptosis. Result: The studies demonstrated that the tumor inhibitory rate of SSCE in low dose group was the highest (30.65%) on Lewis lung cancer. SSCE can resist metastasis, at the same time, it can induce cell cycle arrested in G1 phase, whereas, there was no significant difference in apoptotic rate each group. Conclusion: We verified that SSCE exits anti-tumor effect and resist metastasis, furthermore, it can arrest function cell in G1 phase.

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