---

期 刊 ：中国中药杂志 2008年 33卷 01期 页码：82.

关键词：反复呼吸道感染；儿童；中药；卡慢舒；免疫干预；辅助性细胞(TH)；

Keywords:recurrent respiratory tract infection, children, Chinese materia medica, carboxymethyl, immune intervention, t-helper lymphocyte,

摘 要 ：目的:探讨中药对小儿反复呼吸道感染的免疫干预影响。方法:随机分为观察组和对照组,观察组采用中药,2次/天口服。对照组用口服卡慢舒,<4岁,每次3 mL;4~7岁,每次5 mL;>7岁,每次7 mL。每日3次。两组疗程均为8周。治疗前后两组测定血IL-12,TNF-α,IL-6,IL-13,IL-2,IL-4的变化并进行分析。结果:中药治疗后患儿的IL-12,IL-2的含量比治疗前升高。而TNF-α,IL-13,IL-4,IL-6的含量比治疗前降低。与对照组同期比较P<0.01,观察组治疗前比较P<0.01。随访1年,观察组临床呼吸道感染年均次数明显减少,与对照组比差异有显著性(P<0.01)。结论:中药能有效干预儿童反复呼吸道感染,增强儿童的抗病能力。

Abstract:Objective: To explore the effect of Chinese materia medica on immune intervention of infantile recurrent respiratory tract infection.Method: Thirty-one children of recurrent respiratory tract infection were randomly divided into two groups: therapy group was treated with oral Chinese materia medica(b.i.d),control group was only treated with oral carboxymethyl liquor(<4 years,3 mL;4-7 years,5 mL;>7 years, 7 mL,t.i.d).The change of IL-12,TNF-α,IL-6,IL-13,IL-6 and IL-4 in different time were observed and analyzes.Result: Compared with the control group,the level of IL-12 and IL-2 was significantly increased after treatment of oral Chinese materia medica(P<0.01),however,the level of TNF-α,IL-13,IL-4,and IL-6 was decreased after treatment(P<0.01).During one years‘ follow-up study,the frequency of respiratory infection every year of therapy group was significantly decreased than that of control group.Conclusion: Chinese materia medica could prevent infantile recurrent respiratory tract infection effectively,increase humoral immunity function and ensure normal growth in children.

---