---

作 者 ：孙月娥,王卫东,李超

期 刊 ：中国中药杂志 2010年 35卷 6期 页码：794.

关键词：溶栓；抗栓；溶栓药物；微生物；纤溶酶；临床应用；

Keywords:thrombolysis, antithrombotic, thrombolytic drug, microorganism, fibrinolytic enzyme, thrombolytic drugs, clinical application,

摘 要 ：心脑血管疾病是严重危害人类生命健康的疾病,溶栓疗法是目前最重要的治疗方法之一,微生物是溶栓药物的重要来源。已临床使用的溶栓药物主要是纤溶酶原激活剂类,存在许多缺陷。作者通过对不同来源溶栓酶特点、溶栓作用和临床应用状况的分析, 评价了其疗效与安全性,为开发新型高效溶栓药物、预防和治疗血栓栓塞性心脑血管疾病指明了方向。

Abstract:Cardio-cerebral vascular diseases endanger people‘s health very seriously.Thrombolytic therapy is effective in curing thrombotic diseases at present.Microorganism is an important source of thrombolytic drug. Plasminogen activators are widely used as thrombolytic drugs clinically, while they are still exists some defects. This article analyzed research and development status of kinds of thrombolytic drugs from microorganisms, and evaluated their clinical efficacy and safety, aiming at showing the direction to search new and effective thrombolytic drugs and prevent and treat thromboembolic disease.

---