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期 刊 ：中国中药杂志 2007年 32卷 12期 页码：1167.

关键词：微波炮制；补骨脂；均匀设计；回归分析；

Keywords:micro- wave processed, Psoralea corylifolia, uniform design, regression analysis,

摘 要 ：目的：以补骨脂素、异补骨脂素的总含量、出膏率为指标,优化补骨脂微波炮制工艺。方法：采用均匀试验设计,利用高效液相色谱法测定补骨脂素、异补骨脂素含量,通过逐步非线性回归、等高线图优化提取工艺。结果：补骨脂最佳微波炮制工艺为：食盐溶液浓度20%、浸泡时间6 h、强微波、微波时间270 s。模型预测值的绝对误差分别小于6%和0.3%。结论：回归模型可以对实验结果进行高精度的预测,表明微波炮制补骨脂工艺可行。

Abstract:Objective：To optimize the herb processing process for the total contains of psoralen and isopsoralen and the rate of extract in Psoralea corylifolia by micro-wave herb processing.Method： The contains of psoralen and isopsoralen was obtained by HPLC.The micro-wave herb processing process was optimized by the way of uniform design and contour map.Result： The optimum process was：20% as salt concentration,4h as immerse time, micro-wave strength as strong ,270seconds as micro-wave time. The absolute error of the predicted value from the models were smaller than 6% and 0.3% respectively.Conclusion： The regression models are notable and reasonable, which can forecast results precisely.

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