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期 刊 ：中国中药杂志 2005年 30卷 17期 页码：1328.

关键词：隐丹参酮；羟丙基-β-环糊精；包合物；溶出度；

Keywords:cryptotanshinone, hydroxypropyl-β-cyclodextrin, inclusion compound, dissolution,

摘 要 ：目的:制备隐丹参酮-环糊精包合物,提高隐丹参酮(CT)的溶出度。方法:绘制CT-羟丙基-β-环糊精(HPCD)相溶解度曲线,以确定包合比例;采用湿研磨法制备隐丹参酮-环糊精包合物;利用体外溶出度、差热分析、红外光谱等方法研究包合物的性质。结果:CT与HPCD的包合比例为1∶1,CT-HPCD包合物在45 min的溶出度可达到原料药的21.6倍。结论:包合物能显著提高CT的溶出度,包合物包结作用的热力学键力是CT分子的羰基与HPCD分子的羟基形成氢键。

Abstract:Objective: To prepare cryptotanshinone(CT)-cyclodextrin inclusion compound and improve dissolution of CT. Method: Inclusion ratio was determined by plotting the phase solubility curve of CT versus hydroxypropyl-β-cyclodextrin (HPCD). CT-cyclodextrin inclusion compound was made by wet grinding method. Properties of the inclusion compound was investigated by in vitro dissolution test, DTA and IR spectrum. Result: Inclusion ratio of CT versus HPCD was 1∶1. Dissolution of CT-HPCD inclusion compound at 45 min was 21.6 times of material drug. Conclusion: Dissolution of CT was improved remarkably in CT-HPCD inclusion compound. The complexation force of the inclusion compound was hydrogen bond formed by carbonyl group of CT and hydroxyl group of HPCD.

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