Abstract:Objective: To compare the penetrating rate of muscone in different inclusion complexes and liposome. Method: The transdermal effect of muscone in different inclusion complexes and liposome was studied comparatively on rat skin with 40%EtOH as the absorption solution and with an improved Franz diffuse cell. Result: Among the different inclusion complexes and liposome, the penetrating rate of muscone in the HP-β-cyclodextrin inclusion and the liposome were higher than muscone,and that of muscone in the β-cyclodextrin inclusion is the lowest. Conclosion: the HP-β-cyclodextrin inclusion and the liposome can hence the muscone transdermal speed.