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期 刊 ：中国中药杂志 1999年 24卷 02期 页码：104.

关键词：补肾健脑1号合剂；学习记忆；抗疲劳；兴奋性；

Keywords:Bushenjiannao l decoction, learning and memory, anti fatigue ability, excitability,

摘 要 ：目的：观察补肾健脑１号合剂的抗痴呆作用。方法：采用东莨菪碱及环己亚酰胺致小鼠学习记忆障碍模型，以水迷宫为学习记忆评价指标。并观察该药对小鼠自主活动性和抗疲劳能力的影响。结果：补肾健脑１号合剂中剂量（１５ｇ／ｋｇ）及大剂量（４５ｇ／ｋｇ）能显著改善东莨菪碱致学习记忆障碍的作用；大剂量有显著改善环己亚酰胺致学习记忆障碍的作用，且显著提高抗疲劳能力；自主活动性组间均无显著性差异。结论：补肾健脑１号合剂能显著改善小鼠学习记忆障碍，提高抗疲劳能力，对中枢神经系统兴奋性无显著影响。

Abstract:Objective:To observe the anti dementia effect of Bushenjiannao 1 decoction on mice.Method:The learning and memory tests were realized with a water maze on the learning and memory impact of mice induced by scopolamine and cycloheximide.The effect of Bushenjiannao l decoction on the independent activity and anti fatigue ability of mice were also investigated.Result:Bushenjiannao l decoction used at a medium dose of 15g crude drug/kg and a higher dose of 45g crude drug/kg could significantly improve the learning and memory abilities of mice injected with scopolamine.Higher doses could improve these abilities of mice injected with cycloheximide,and also improve the anti fatigue ability of mice.No significant differences were observed in the independent activity of mice between the groups.Conclusion:Bushenjiannao l decoction helps improve the learning and memory abilities and enhance the anti fatigue ability,but has no effect on excitability of the central nervous system.

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