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期 刊 ：中国中药杂志 1998年 23卷 07期 页码：429.

关键词：芫花；离体子宫平滑肌；前列腺素；异搏定；抗早孕；

Keywords:Yuanhua, uterine muscle strips, prostaglandin, verapamil, anti-early-pregnant,

摘 要 ：目的:观察芫花根皮水煎剂对人工动情期大鼠离体子宫平滑肌条的作用,以探讨其作用机理。方法:将离体子宫平滑肌条悬挂于离体平滑肌灌流肌槽装置内,采用分离加药的方法以观察结果。结果:芫花根皮水煎剂可兴奋大鼠离体子宫平滑肌并有剂量依赖性关系;阿托品、酚妥拉明、六烃季胺、苯海拉明不能阻断芫花兴奋大鼠离体子宫平滑肌的作用;异搏定可完全阻断芫花兴奋大鼠离体子宫平滑肌的作用,前列腺素合成酶抑制剂消炎痛可使芫花的兴奋作用降低。结论:芫花对未孕大鼠离体子宫平滑肌条的兴奋作用,可能是通过作用于平滑肌细胞膜的Ca2+通道和部分刺激前列腺素合成、释放的途径实现的。

Abstract:Objective: To explore the mechanism on the effect of Yuanhua on the contractile activity of isolated uterine strips in rats under artificial oestrum Method:Isolated strips were suspended in a tissue chamber in which Yuanhua was added with some antagonists of inhibitors or without Result: Yuanhua could excite the uterine smooth muscle strips in a dose dependent manner, but atropine,phentolamine,hexamethonium and diphenhydramine could not inhibit this exciting actionThis exciting effect could be inhibited completely by verapamil and decreased by indomethacin(inhibitor of prostaglandin synthase)Conclusion:The exciting effect of Yuanhua on un pregnant rats in vitro might be related to an action on the cell membrane Ca²⁺channel as well as to a partial stimulation of synthesis and release of PG.

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