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期 刊 ：中国中药杂志 1998年 23卷 09期 页码：554.

关键词：肉苁蓉总甙；超氧化物歧化酶；丙二醛；脂褐质；抗氧化；

Keywords:glycosides of Cistanche, superoxides dismutase, malondialdehyde, lipofuscin, anti oxidation,

摘 要 ：目的：研究肉苁蓉总甙（ＧＣＳ）对小鼠组织的抗氧化作用。方法：采用邻苯三酚自氧化、硫代巴比妥酸（ＴＢＡ）和荧光法，分别测定小鼠心、肝、脑、肾组织中ＳＯＤ活性、ＭＤＡ及脂褐质含量。结果：ＧＣＳ（１２５ｍｇ／ｋｇ，２５０ｍｇ／ｋｇ）组能显著提高脑、肾组织中ＳＯＤ活性，２５０ｍｇ／ｋｇ时提高心、肝组织中ＳＯＤ活性，并显著降低各组织ＭＤＡ及脂褐质含量。结论：结果提示ＧＣＳ能有效地提高机体组织抗氧化能力，防止组织脂质过氧化损伤。

Abstract:Objective:To study the anti-oxidative action of GCS in the tissues of mice.Method:Contents of superoxide dismutase (SOD),malondialdehyde (MDA)and lipofuscin in the heart,liver,brain and kidney of mice were measured,using pyrogallic acid,thiobarbi turic acid(TBA)and fluorescent technique respectively.Result :It was found that the GCS (125mg/kg,250mg/kg)had a significantly higher SOD activity and lower MDA contents in brain and kidney than that in control group.GCS(250mg/kg)enhanced SOD activity in the heart and liver, declined contents of MDA and lipofuscin in all tissues.Conclusion:The results suggest that GCS could increase the antioxidative action in vivo significantly and prevent lipoperoxidative damages in tissues.

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