Abstract:Experimental data indicated that Acanthopanax giraldii given intraperitoneally in nuce had pronounced in-hibitory effects on the CNS. It reduced the spontaneous activity , prolonged the hypnotic time of pentobarbital sodi-um and antagonised the amphetamine-induced hyperactivity. The results suggest that the sedative effect of A. gi-raldii is probably different from that of diazepam , but perhaps similar to that of reserpine.