Abstract:The protective effect of total flavonoids of Radix Astragali (TFA)on V79 cell damage caused by H2O2-Fe2 sys-tem has been studied. The results show that total flavonoids of Radix Astragali inhibit lipid peroxides and increase SODactivity. It has also been found that TFA has different protective effect against various damages of V79 cells caused byhydroxyl radical.