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期 刊 ：中国中药杂志 1993年 18卷 09期 页码：535.

关键词：荆芥；荆芥炭；止血；量效关系；时效关系；

Keywords:Schizonepeta tenuifolia, carbonized Schizonepeta tenuifolia, hemostasis, dose-response relationship, time-response relationship,

摘 要 ：研究结果表明,荆芥炭的脂溶性提取物StE具有明显的止血作用,在一定剂量范围内,其对数剂量与小鼠的凝血和出血时间的倒数呈显著性线性相关。StE给小鼠ip后0.5h,家兔po后1h即可见到明显的止血作用,其作用维持时间分别为6h及12h。StE的LD₅₀(po)为2.652±0.286g/kg,LD₅₀(ip)为1.945±0.207g/kg。

Abstract:It has been shown that the fatsoluble extract SeE from carbonized Schizonepeta tenuifolia has an obvious hemostatic action. In a given range of dose there is a significant linear correlation between the logarithms of its doses and the reciprocal of the bleeding and coagulating times in mice, Obvious hemostatic action was observed after mice had been administered in ip and po respectively for 0.5h and 1h. The hemostatic time of the former was 6h and the latter 12h. The LD₆₀ of StE in po was 2.652±0.286g/kg, while in ip 1.945±0.207g/kg.

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