Abstract:L9(34) orthogonal design was adopted to inspect the consumption of white sugar, water and ethanol and the duration of raw material mixing in relation to the granule-attaining rate in pre- paring Luohanguo-Chrysanthemum granule medicine. The result shows that with a consumption of 170kg of white sugar, 6000ml of water and 800ml of ethanol and a duration of 8 minutes, the granule attaining rate reaches about 80%.