Abstract:Objective To study the formulation and preparation factors influencing in vitro release mechanism of drug from κ-carrageenan/konjac glucomannan hydrophilic matrix tablets.Methods The matrix tablets containing sinomenine hydrochloride as a model drug were obtained by direct compression method or wet granulation technique.The effects of the ratios of ,κ-carrageenan/konjac glucomannan, the amount of matrix materials,the kinds of diluent agent，tablet size，preparation method，and compressing pressure on release mechanism of the matrix tablets were studied by evaluating the n value in the Peppas equation.Results The release mechanism of the matrix tablets was non-Fickian release that coupled diffusion and erosion modle.With a decrease in the ratio of κ-carrageenan/konjac glucomannan，a decrease in the amount of matrix materials,a decrease in the water-solubility of diluent agents，an increase in tablet size，and a decrease in compressing pressure, the ratio of drug diffusion was increased. Preparation method had little influence on drug release mechanism. Conclusion Drug could be slowly released from the matrix tablets containing -carrageenan/konjac glucomannan as matrix material，the main factors influencing drug release mechanism are the ratio of κ-carrageenan/konjac glucomannan, the amount of matrix materials，the kinds of diluent agent，tablet size, and compressing pressure.