Abstract:Objective To explore the effect ofAcorus gramineusand its component α-asarone on the ability of the experimental you-ng rats with epilepsy induced by pentylenetetrazol(PTZ)to move and memorize.Methods Wistar young rats were randomly divided into normal control group(NC),epileptic model group(A),phenobarbital sodium group(B),A.gramineusgroup(C),and α-asarone group (D).The epileptic model was established by ip PTZ 60 mg/kg and rats in all groups were given the tested drugs by ig.Changes of move-ment in inclined plate test,over hanging test,autonomic movement test and changes of spatial learning ability and memory in Morris water maze test were observed in Wistar young rats.Results The ability of rats in groupAto writhe body,suspend body,and move automatically as well as spatial learning ability and memory were obviously decreased,which had positive correlation to the extent of eclampsia.Group B is secondary to group A.There were significant differences between the above mentioned results and the other three groups(P<0.05).But there was no obvious difference among group NC,group C,and group D.Conclusion The damage of moving and learning ability and memory function of the young rats caused by frequent epilepsy paroxysm induced by PTZ could be reve-rsed more efficiently by α-asarone and A.gramineus than phenobarbital sodium.