全 文 :中草药ChineseTraditionalandHerbalDrugs第36卷第9期2005年9月·1285·
化学成分
GrosmomosideI,anewcucurbitane
fromfruitsofMomordica
triterpenoidglycoside
grosvenort
YANGXiu—weil,ZHANGJian-yel,QIANZhong—min92
(1.StateKeyLaboratoryofNaturalandBiomimeticDrugs,SchoolofPharmaceuticalSciences,andMedical
andHealthyAnalysisCenter,PekingUniversity,Beijing100083,Chinaj2·Polytechnic
UniversityofTheHongKong,Hongkong,China)
Abstract:ObjectiveTocarryoutasystematicstudyonthechemicalconstituentsinthefruitsofMo—
mordicagrosvenori.MethodsToisolatepurecompoundsbyusingrepeatedcolumnchromatography,
whilethestructureofan wcompoundwasdeterminedbydetailedspectralanalysis.ResultsFo rcucur—
bitanetriterpenoidglycosides,mogroside11E(I),mogroside噩(Ⅱ),grosmomosideI(111),and
mogrosideV(1V)wereisolatedfromthe50%ethanolicextractofthefruitsofM.grosvenori.Conclusion
GrosmomosideI isan wcompoundidentifiedasmogrol一3一O—pD—91ucopyranoside一24一O一{[pD—glu—
copyranosyl(2—1)]一[pD—glucopyranosyl(6—1)]一pD—galactopyranoside}andtheotherthreecompoundsare
knowncompounds.
Keywords:MomordicagrosvenoHSwingle;triterpenoidsaponin;grosmomosideI
罗汉果中一新葫芦烷型三萜皂苷 光果木鳖皂苷I
杨秀伟1,张建业1,钱忠明2
(1.北京大学天然药物及仿生药物国家重点实验室北京大学医药卫生分析中心,北京 100083;
2.香港理工大学应用生物及化学科技学系,香港)
摘 要:目的 研究罗汉果中的化学成分。方法 用各种色谱法分离和精制纯品化合物,通过各种谱学方法鉴定其
结构。结果从罗汉果乙醇提取物中得到4个葫芦烷型三萜皂苷,分别为:罗汉果皂苷Ⅱe(mogrosideⅡE,I)、罗
汉果皂苷11I(mogrosideⅢ,I)、光果木鳖皂苷I(grosmomoside,1)和罗汉果皂苷V(mogrosideV,N)。结论
光果木鳖皂苷I为一新化合物,鉴定其结构为罗汉果醇一3一O—pD一吡喃葡萄糖苷一24-0一{[pD-III:匕喃葡萄糖基(2—1)]一.
[pD一吡喃葡萄糖基(6—1)]一pD一吡喃半乳糖苷{mogrol一3一O—pD—glucopyranoside一24一O一[pD—glucopyranosyl(2—1)]一
[pD—glucopyranosyl(6—1)]一p—D—galactopyranoside),其他3个化合物为已知化合物。
关键词:罗汉果;三萜皂苷;光果木鳖皂苷I
中图分类号:R284.1 文献标识码:A 文章编号:0253—2670(2005)05—1285—06
1 Introduction
MomordicagrosvenoriSwingleisaplantgrow—
inginGuangxi,Hunan,Guizhou,Guangdong,
andJiangxiProvincesofChina.Thefruitsofthe
plantareusedintraditionalChinesemedicineasa
pulmonarydemulcentandemollientforthetreat—
mentofdrycough,soreth oat,direth st,consti—
pation[¨.Anumberoftriterpenoidsaponinswere
previouslyreportedfromthisplant[2一引.Inthispa—
per,theisolationandsturctureelucidationofa
newc curbitanetypetriterpenoidglycosidenamed
asgrosmomosideI(In),andknowncompounds
mogrosideⅡE(I),mogrosideⅢ(Ⅱ),and
mogrosideV(Ⅳ).arereported
2 Materialsandmethods
2.1 Plantmaterial.ThefrutisofM.grosvenori
箨薯品羿:荔凳杀乏116958--),男,博士,教授,博士生导师,北京大学医药卫生分析中心副主任,北京大学天然药物及仿生药物国家重点实作者简介 杨秀伟( ),男,博士 教授,博士生导师,北京大学医药卫生分析中心副主任,北京大学天然药物及仿生药物国家重点实
验室药学与化学分析实验室主任,主要从事天然药物化学研究。
Tel:(010)82801569,62070317E—mail:xwyang@mail.bjmu.edu.cn
万方数据
·1286· 中草药ChineseTraditionalandHerbalDrugs第36卷第9期2005年9月
wereobtainedfromtheAnguoCityin Hebei
ProvinceofChinainApril2001andidentifiedby
ProfessorCaiShao—qing.Avoucherspecimenof
theplantisdepositeda theHerbalriumofSchool
ofPharmaceuticalSciences,PekingUniversity.
2.2 Generalexperimentalprocedures.Infrareds
(IR)weretak no aNexus470FT—IRspectro-
meter(nicolet).Opticalrotationsweredetermined
onaPerkin—Elmer243Polarimeter.1H—NMRand
-3C—NMRspectrawereperformedona Varian
INoVA一500spectrometerinpyridine-d5at500
MHzfor1H—NMRandl25MHzfor13C—NMR.
Chemicalshiftsaregiveni 艿relativetoTMSas
aninternalstandard.ESI—TOF—MSandHR—SI—MS
wereperformedonMDSCIEXAPIQSTARand
APEXⅡFT—ICR(BrukerDaltonics)massspec—
trometer,respectively.MacroporousresinDi ion
101wasproducedbyNankaiUn versityofChina.
2.3 Extractionandisolation.Powderedfruitsof
M.grosvenori(8kg)wererefluxedwith50%
Et0Htoaffordethanolicextract.Theextractwas
suspendedinH20andpartitionedsuccessivelywith
cyclohexane,EtOAcandBu Htoaffordcorres—
pondingextracts,16g(yield0.2%),101g
(1.26%)and569g(7.11%),respectively.The
BuOHextractwasubjectedtocolumnchromato—
graphyoverDiaion101elutingwithH20(10L),
20%EtOH(12L)and50%Et0H(2L),respec—
tively.The500AEtOHfractionwasubjectedto
columnchromatographyonsilicagel(200—300
mesh)andelutedwithCHCl3-MeOH(9:1—1:
1)toyieldsevensub—fractions.Theywerepurified
repeatedlyonsilicagelandpolyamidecolumnchro—
matographytoaffordcompoundI(60rag)from
thesub—fr.2,compoundⅡ(2g)fromthesub—
fr.3,compoundⅢ(40mg)fromthesub~fr.6,
andcompound1V(80mg)fromthesub-fr.7,
respectively.
3 IdentificatiOn
CompoundI (mogrosideⅡE):Awhite
amorphousp wder,C42HTzOl4.IR燃cm~:3417
(oH),1644,1466,1381,171,1076(oligogly—
cosidicgroups),1024,630,586.ESI—TOF-MS
(positive)m屈:801EM+1]+,823[M+Na3+.
1H—NMR(500MHz,Py-d5):aglyconemoietyda—
ta,seeTable1.Sugarmoieties,C3一glc:艿4.85
(1H,d,,一8.0Hz,H一1),4.00(1H,t,,一8.5
Hz,H一2),4.18(1H,t,J=7.5Hz,H一3),4.17
(1H,t,J=7.5Hz,H一4),3.97(1H,m,H一5),
4.33(1H,dd,J一5.0,12.0Hz,H一6a),4.51
(1H,dd,,一2:0,12.0Hz,H一6b);C24-glc:d
4.96(1H,d,,=7.5Hz,H一1),3.92(1H,t,J一
8.3Hz,H一2),4.17(1H,t,J一8.0Hz,H一3),
4.13(1H,t,J一8.0Hz,H一4),3.89(1H,m,H一
5),4.29(1H,dd,J=5.0,12.0Hz,H一6a),4.47
(1H,dd,J一2.0,12.0Hz,H一6b),13C—NMR
(125MHz,Py-d5):aglyconemoietydata,see
Table1.Sugarmoieties,C3-Glc:艿107.3(C一1),
75.2(C一2),78.0(C一3),71.5(C一4),78.4(C一
5),62.8(C一6);C24-·glc:艿105.8(C一1),75.3(C一
2),78.3(C一3),71.6(C一4),78.5(C一5),62.5
(C一6).
CompoundⅡ(mogroside11I):Awhiteamor—
phouspowder,C48H82019.IR艘cm~:3419
(OH),1640,1465,1382,171,1076(oligogly—
cosidicgroups),1024,630,586.ESI—TOF—MS
(positive)m/z:963[M+1]+,985[M+Na3+.
1H—NMR(500MHz,Py—d5):O.80(3H,s,Me一
30a),O.88(3H,s,Me一1813),0.89(1H,d,,一
5.5Hz,M一2113),1.05(1H,m,H~158),1.10
(1H,m,H一15a),1.12(3H,s,Me一26),1.28
(3H,s,M一1913),1.28(3H,s,M一2713),1.40
(3H,s,M一2913),1.43(1H,m,H~1613),1.47
( H,m,H一20a),1.49(1H,m,H~23a),1.52
(3H,s,Me一28a),1.61(1H,d,J=7.0Hz H一
813),1.63(1H,d,J一6.0Hz,H一7a),1.64(1H,
m,H一17a),1.67(1H,m,H一2313),1.70(1H,m,
H一2213),1.73(1H,m,H一22a),1。82(1H,m,H一
16oc),1.93(1H,t,J一10.5Hz,H一113),1.98
(1H,m,H一1213),2.03(1H,m,H一12a),2.04
(1H,t,J一10.5Hz,H一2a),2.26(1H,dd,J=
5.5,17.5Hz,H一713),2.40(1H,d,J一10.5Hz
H一213),2.74(1H,d,J一10.5Hz,H一10a),2.88
(1H,d,J一10.5Hz,H—la),3.64(1H,m,H一
3a),3.72(1H,d,J一10.0Hz,H~24a),4.16
(1H,d,J一8.5Hz,H一1113),5.43(1H,d,J一
6.0Hz,H一6).Sugarmoieties,C3-glc(A):艿4.80
万方数据
中草药ChineseTraditionalandHerbalDrugs第36卷第9期2005年9月·1287·
Table1 NMRdataand13C_lHcorrelationofaglyconeofgrosmomosideI anmogrosideIE(inPy—d5)
HSQC
C H 粕;J/Hz & HMBC
grosmomosideI mogrosideIE grosmomosideI mogrosidelE
+:AandCarepresentedforglueosylgroupatC3ofgrosmomside
(1H,d,J一7.5Hz,H一1),3.83(1H,m,H一5),
3.90(1H,t,J一8.5Hz,H一2),4.11(1H,t,J=
7.5Hz,H一4),4.13(1H,t,J=7.5Hz H一3),
4.32(1H,dd,J一4.5,9.0Hz H一6a),4.47
(1H,dd,J一2.0,9.0Hz,H-6b);C24-glc(B):艿
4.86(1H,d,,一8.5Hz,H一1),4.19(1H,m,H一
5),4.02(1H,t,J一8.0Hz,H一2),4.03(1H,t,
J一8.5Hz,H一4),4.14(1H,t,J一4.5Hz,H一
3),3.93(1H,dd,,一4.5,9.0Hz,H一6a),4.92
(1H,d,J=8.5Hz,H-6b),C24-glc(C):艿4.85
(1H。d,L,一7.5Hz,H一1),3.89(1H,m,H一5),
4.00(1H,t,J=7.5Hz,H一2),4.22(1H,t,J=
I angalactosylgroupatCz4ofgrosmomosideI,respectivelyinFig.1.
7.5Hz H一4),3.93(1H,t,J一7.5Hz,H一3),
4.34(1H,t,J一3.0Hz,H一6a),4.46(1H,d,
J=10.0Hz,H一6b).”C—NMR(125MHz,Py—
d5):aglyconemoiety,艿26.6(C一1),29.4(C一2),
87.8(C一3),42.2(C一4),144.1(C一5),118.3(C一
6),24.4(C一7),43.3(C一8),39.9(C一9),36.7
(C一10),77.6(C一11),40.9(C一12),47.2(C一13),
49.5(C一14),34.4(C一15),28.1(C一16),50.9
(C一17),16.9(C一18),26.2(C一19),36.1(C一20),
18.6(C一21),32.9(C一22),29.4(C一23),92.6
(C一24),72.5(C一25),24.1(C一26),26.8(C一27),
27.6(C一28),26.1(C一29),19.1(C一30);sugar
万方数据
·1288· 中草药ChineseTraditionalandHerbalDrugs第36卷第9期2005年9月
moieties,C3一glc(A):艿107.3(C一1),75.3(C一2),
77.9(C一3),71.2(C一4),78.4(C一5),62.8(C一
6);C24一glc(B):艿106.2(C一1),74.9(C一2),78.5
(C一3),71.9(C一4),76.2(C一5),70.3(C一6);C24一
gle(C):d104.7(C一1),75.3(C一2),78.4(C~3),
71.5(C一4),78.0(C一5),62.3(C一6).
CompoundⅢ(grosmomosideI):Awhite
amorphousp wder,C54H92024.IR熄cm一:3384
(oH),1643,1465,1381,171,1075(oligogly—
cosidicgroups),1029,629,580.ESI—TOF~MS
(negative)m/z:1223[M一1]一;ESI—TOF~MS
(positive)优/2:1147[M+Na]+;HR—SI—MSm/
2:calcd.forC54H92Na024:1147.5870;found:
1147.5846[M+Na]+.1H—NMRand13C—NMR
(500MHz,Py—d5)spectralanalysis,seeTabl s1
and2.
Table2 NMRdataand”C-IHcorrelationofsugarmoietiesofgrosmomosideI( nPy—ds)
CompoundIV(mogrosideV):Awhiteamor—
phouspowder,C60H】02029.IR《窦em~:3419
(OH),1642,1465,1381,169,1075(oligogly—
cosidicgroups),1033,633,588.ESI—TOF—MS
(negative)m/z:1285[M一1]一;ESI—TOF—MS
(positive)m/z:1309EM+Na]+;1H—NMR(500
MHz,Py—d5),aglyconemoiety拶:0.90(6H,S,
Me一30a;Me一186),1.04(1H,m,H一15B),1.06
(3H,S,Me一28a),1.06(3H,d,J=6.5Hz Me一
2118),1.12(1H,m,H一15a),1.30(3H,S,Me一
27),1.31(3H,S,M一1913),1.43(3H,S,M一26),
1.45(1H,m,H一168),1.49(3H,S,Me一296),
1.51(1H,m,H一20a),1.54(1H,d,J一7.5Hz,
H一86),1.59(1H,d,L厂一7.0Hz,H一7a),1.62
(1H,m,H一17a),1.76(1H,m,H一226),1.78
(1H,m,H一22a),1.86(1H,m,H一23a),1.97
(1H t,J一10.0Hz,H一18),2.03(1H,m,H一
23a),2.06(1H,m,H一16a),2.10(1H,m,H~
126),2.12(1H,m,H一12a),2.17(1H,t,J=
12.5Hz H一2a),2.24(1H,dd,J=7.0,17.5
万方数据
中草药ChineseTraditionalandHerbalDrugs第36卷第9期2005年9月·1289。
Hz,H一76),2.46(1H,d,J一10.0Hz,H一28),
2.78(1H,d,J一10.OHz,H一100c),2.98(1H,d,
J一10.0Hz,H一1a),3.66(1H,m,H一3a),3.73
(1H,d,,=8.0Hz,H一24a),4.13(1H,d,J=
8.5Hz,H一1113),5.44(1H,t-like,H-6).Sugar—
moieties,C3-glc(A):艿4.78(1H,d,,一8.0Hz,
H一1),3.91(1H,dd,J一5.0,8.5Hz,H一2),
4.23(1H,m,H一3),4.28(1H,m,H一4),4.00
(1H,t,J一5.0Hz,H一5),4.32(1H,dd,J=
5.0,12.5Hz,H一6a),4.76(1H,d,t,一12.5Hz
H一6b);C3-glc(B):艿5.14(1H,d,,一7.5Hz,
H一1),4.03(1H,dd,J一5.0,8.0Hz,H一2),
4.26(1H,m,H一3),4.24(1H,m,H一4),3.88
(1H,m,H一5),4.36(1H,dd,,=5.0,11.7Hz,
H一6a),4.50(1H,d,,=11.5Hz,H一6b),C24-glc
(C):艿4.90(1H,d,J一7.0Hz,H一1),4.14
(1H,m,H一2),4.20(1H,m,H一3),4.18(1H,
m,H一4),4.02(1H,m,H一5),4.89(1H,d,J一
12.5Hz,H一6b),3.93(1H,dd,J=5.0,11.0
Hz,H一6a);C24-glc(D):艿4.84(1H,d,J=7.5
Hz。H一1),4.02(1H,m,H一2),4.22(1H,m,H一
3),3.91(1H,m,H一4),4.02(1H,m,H一5),
4.50(1H,d,J一11.5Hz,H一6b),4.36(1H,dd,
J一5.0,11.5Hz,H一6a);C24-glc(E):艿5.43
(1H,d,J一7.5Hz,H一1),4.06(1H,m,H一2),
4.17(1H,m,H一3),4.08(1H,m,H一4),3.93
(1H,m,H一5),4.47(1H,d,J=12.5Hz H一
6b),4.30(1H,dd,,=5.0,12.5Hz,H一6a).
13C—NMR(500MHz,Py-d5):aglyconemoiety,8
26.6(C一1),29.3(C一2),87.3(C一3),42。1(C一
4),144.1(C一5),118.2(C一6),24.3(C一7),43.3
(C一8),39.9(C一9),36.5(C一10),77.7(C一11),
40.9(C一12),47.2(C一13),49.5(C一14),34.3
(C一15),28.3(C一16),50.9(C一17),16.9(C一18),
26.1(C一19),36.2(C一20),18.9(C一21),33.0
(C一22),29.2(C一23),91.9(C一24),72.6(C一25),
24.3(C一26),26.8(C一27),27.4(C一28),26.1
(C一29),19.2(C-30);sugarmoieties,C3-glc(A):
艿106.8(C一1),75.2(C一2),78.4(C一3),71.4(C一
4),77.1(C一5),70.1(C一6);C3-glc(B):艿105.4
(C一1),75.1(C一2),78.3(C一3),71.4(C一4),
78.1(C一5),62.5(C一6);C24-glc(C):艿103.4(C一
1),82.2(C一2),76.2(C一3),72.6(C一4),77.8
(C一5),70.0(C一6);C24-glc(D):艿104.6(C一1),
75.O(C一2),78.2(C一3),71.2(C~4),78.0(C一
5),62.3(C一6);C24-glc(E):艿105.2(C一1),75·7
(C一2),78.2(C一3),72.3(C一4),78.2(C-5),
63.4(C一6).
4 Resultsandiscussion
TheBu Hextractofa 50%ethanolicextract
ofthefruitsofM.grosvenoriwasappliedtochro—
matographedovertheDiaion-101elutedwithHzO,
20%EtOH,and50%EtOH,respectively,togive
correspondingfractons.The50%EtOHfraction
wasfurtherpu itiedoversilicagelandpolyamide
columnchromatographyresultingintheisolation
ofthecompoundsI—IV.respectively.
CompoundsI,Ⅱ,andⅣwereidentifiedas
mogrosideⅡE,mogrosideⅢ,andmogrosideV
(Fig.1),respectivelybymeansof1Dand2D
NMRspectroscopictechniquesincluding1H—NMR,
13C—NMR,1H 1HCoSY,NOESY,DEPT,
HMQC,andHMBC.
R
Rl R2
I:mogr”ide118
GAI。 GBI‘
II:mogroside1Ii OIc GIo二Gk
A B C
III:grosmomosideI GIc B0a1.L土Glc
A f: c
DGIc
Iv:mogrosideV Gk上kkc牟—~b
A B f÷D
Gk
E
Fig.1StructuresofcompoundsI一Ⅳ
CompoundⅢwasobtainedsa whiteamor—
phouspowder,showeda p sitiveLi berman—Bur—
chardeaction,whichsuggesteditwasa triter—
penoid.ItsIRspectrumshowedstrongabsorption
bands(3384and1075cml)forhyd oxylgroups
andtheoligoglycosidicstructure[引.Themolecular
formulaC54H92024wasdeducedfromthemolecular
ionatm/z1147EM+Na]+initsESI—TOF—MS
andconfirmedbyHR—SI—MS(1147.5846EM+
Na]+,calcd.1147 587o),anditwasupported
by13C—NMRandDEPTspectra.The13C—NMR
万方数据
·1290· 中草药ChineseTraditionalandHerbalDrugs第36卷第9期2005年9月
spectrum(Table1)ofcompoundⅢsuggesteda
triterpenoidwithabasicstructuresimilartocucur—
bitane—glycosides[7|.whichrevealed24carbonsig—
nalsfortheglyconeportionand30carbonsignals
fortheaglyconeportionincludinga quaternary
oxygenatedcarbonsignal(艿72.2)。threeme in
oxygenatedcarbonsignals(艿87.2,77.7,and
87.9),atertiaryolefiniccarbonsignal(艿144.1)
andamethineolefiniccarbonsignal(艿l18.2).
Comparingw ththe13C—NMRspectrumof
compoundI(mogrosideⅡE)whichismogrol-3一
。一pD—glucopyranoside一24一。一pD—glucopyra—
noside,compoundⅢhasmogrol一3一O—pD—blu—
copyranosidemo ety,whiletwosugarresidues
wereaddedandthechemicalshiftofC24was
changed.Thissuggestedthatwoadditionalsugar
residuesb correlatedwithglucopyranosylgr up
ofC24.AfteracidhydrolysisofcompoundⅢ,D—
glucoseandD—galactosewerdetectedbyPPCand
comparedwithauthenticsamples.The1H—NMR
spectrumofcompoundⅢdisplayedsignalsoffour
anomericprotonsat艿4.74(d,,=7.5Hz),4.99
(d,,一8.0Hz),5.08(d,J=8.0Hz),5.27(d,
J一8.0Hz),whichcorrelatedwiththecarbonsig—
nalsat8106.8,101.7,105.2and106.0,respec—
tively,intheHSQCspectrum.IntheHMBCand
1H一1HCOSYspectraofcompoundⅢ(Fig.2),the
signalofglucose(A)anomericprotonat艿4.74
wascorrelatedwiththatofmogrolC3at艿87.2and
艿4.74,3.91,4.10,4.09,3.83,4.30,4.47be—
longedtothesamespinsystem;thesignalof
galactose(B)anomericprot nat艿4.99wascorre—
latedwiththatofmogrolC24at艿101.7and艿
4.99,4.05,4.05,4.03,.97,4.37,4.70be—
longedtothesamespinsystem;thesignalofglu—
cose(C)anomericprotonat艿5.08wascorrelated
withthatofgalactoseC6at艿70.1and艿5.08,
4.03,4.15,3.92,3.97,4.24,4.47belongedto
thesamespinsystem;thesignalofglucose(D)
anomericprotonat艿5.27wascorrelatedwiththat
ofgalactoseC2at艿83.5anda5.27,4.04,4.09,
3.89,4.07,4.26,4.44belongedtothesamespin
system.Therefore,theglucose(A)wasconnected
Fig.2Somek ycorrelationsobservedinHMBC
(H—-C)forcompoundⅢ
withtheC3ofmogrol,galactose(B)wasconn ct—
edwiththeC24ofmogrol,theglucose(c)wascon—
nectedwiththeC6ofglucose,theglucose(d)was
connectedwiththeC2ofgalactose(Fig.2).The
largeJvaluesindicatedpglycosidicl nkagesinall
cases.Theori ntationoftheprotonatC24wases~
tablishedbytheNOESYcorrelationsofH一24with
H一23andlargeJvalues(H一24,d,,=8.5
Hz)[2—4’引.
Fromtheseresults,thes ructureofcorn—
poundⅢwasestablisheda mogrol一3一O一口一D—glu—
copyranoside一24一O一{[pD—glucopyranosyl(2—1)]一
[pD—glucopyranosyl(6—1)]一pD—galactopyrano—
side),namedasgrosmomosideI.
References:
[-1-1ChPEs].VolI.2000.
[2]TakemotoT,AriharaS,NakajimaT,eta1.Studiesonthe
constituentsofFructursMomordicae.I.Onthesweetprin—
eiple-J].YakugakuZasshi,1983,103(11):1151—1154.
[3]TakemotoT,AriharaS,NakajimaT,eta1.Studiesonthe
constituentsofFructusMomordicae.I.Structureofsa—
pogenin[J].YakugakuZasshi,1983,103(11):1155—1166.
[4]TakemotoT,AriharaS,NakajimaT,eta1.Studiesonthe
constituentsofFructusMomordicae.I.Structureofmogro—
sides[J].YakugakuZasshi,1983,103(11):1167—1173.
[53SiJY,ChenDH,ChangQ,eta1.Isolationndetermina—
tionofcucurbitane—glycosidesfromfreshfruitsofSiraitia
grosvenorii[J].ActaBotSin,1996,38(6):489—494.
[63YangXW,ZhaoJ,CuiYX,eta1.Apairofnewgeometri—
callyisomerictriterpenoidsaponinsfromtheseedsofAescu—
luschinensis[J1.ChinChemLett,1999,10(11):925—928.
E7]KasaiR,N eRL,NashiK.Sweetcucurbitane—glycosides
fromfruitsofSiraitias mensis(chi—ziluo-han—guo),a
Chinesefolkmedicine[J].AgricBiolChem,1989,53:
3347—3349.
[83SakakibaraJ,HottaY,YasueM.Studiesonthecons—
tituentsofLyoniaovalifoliaDrudevar.ellipticaHand.一
Mazz.XX.Structureoftriterpenoidglucoside,lyofolicacid.
(4).Correlationofprotolyofoligenicac dwitheycloartenol
口].YakugakuZ sshi,1975,95(9):1085—1091.
万方数据
罗汉果中一新葫芦烷型三萜皂苷--光果木鳖皂苷Ⅰ
作者: 杨秀伟, 张建业, 钱忠明, YANG Xiu-wei, ZHANG Jian-ye, QIAN Zhong-ming
作者单位: 杨秀伟,张建业,YANG Xiu-wei,ZHANG Jian-ye(北京大学,天然药物及仿生药物国家重点实验
室,北京大学,医药卫生分析中心,北京,100083), 钱忠明,QIAN Zhong-ming(香港理工大学
应用生物及化学科技学系,香港)
刊名: 中草药
英文刊名: CHINESE TRADITIONAL AND HERBAL DRUGS
年,卷(期): 2005,36(9)
被引用次数: 8次
参考文献(8条)
1.中国药典一部 2000
2.Takemoto T;Arihara S;Nakajima T Studies on the constituents of Fructurs Momordicae. I . On the
sweet principle 1983(11)
3.Takemoto T;Arihara S;Nakajima T Studies on the constituents of Fructus Momordicae. Ⅱ . Structure
of sapogenin 1983(11)
4.Takemoto T;Arihara S;Nakajima T Studies on the constituents of Fructus Momordicae. Ⅲ. Structure
of mogrosides 1983(11)
5.Si J Y;Chen D H;Chang Q Isolation and determination of cucurbitane-glycosides from fresh fruits of
Siraitia grosvenorii 1996(06)
6.Yang X W;Zhao J;Cui Y X A pair of new geometrically isomeric triterpenoid saponins from the seeds
of Aesculus chinensis[期刊论文]-Chinese Chemical Letters 1999(11)
7.Kasai R;Nie R L;Nashi K Sweet cucurbitane-glycosides from fruits of Siraitia siamensis (chi-zi
luo-han-guo ),a Chinese folk medicine 1989
8.Sakakibara J;Hotta Y;Yasue M Studies on the constituents of Lyonia ovalifolia Drude var. elliptica
Hand.Mazz. XX. Structure of triterpenoid glucoside, lyofolic acid.(4). Correlation of
protolyofoligenic acid with cycloartenol 1975(09)
本文读者也读过(10条)
1. 凤瓜果实中新的五环葫芦烷葡糖苷和三萜[期刊论文]-国外医学(中医中药分册)2003,25(4)
2. 从异株泻根根中分得的葫芦苦素烷型三萜苷的抗炎和抗肿瘤促进作用[期刊论文]-国外医药(植物药分册)
2003,18(2)
3. 黎海彬.王邕.李俊芳.李小梅.LI Hai-bin.WANG Yong.LI Jun-fang.LI Xiao-mei 罗汉果的化学成分与应用研究
[期刊论文]-食品研究与开发2006,27(2)
4. 齐一萍.唐明仪 罗汉果果实的化学成分与应用研究[期刊论文]-福建医药杂志2001,23(5)
5. 廖日权.李俊.黄锡山.黄艳.何星存.苏小建 罗汉果化学成分的研究[期刊论文]-西北植物学报2008,28(6)
6. 杨秀伟.张建业.钱忠明.YANG Xiu-wei.ZHANG Jian-ye.QIAN Zhong-ming 罗汉果中新的天然皂苷[期刊论文]-中
草药2008,39(6)
7. 丁艳丽.邓旭明.蔡辉.王芳生.王学林.张聿梅.杨峻山 苦味西葫芦化学成分的研究[期刊论文]-中国药学杂志
2002,37(9)
8. 周欣欣 罗汉果的化学成分及其开发应用[期刊论文]-中医药学刊2003,21(9)
9. 石军飞 蒙药木鳖子的化学成分研究[学位论文]2008
10. 关健.潘辉.赵余庆.GUAN Jian.PAN Hui.ZHAO Yu-qing 苦瓜中新葫芦烷型皂苷的研究[期刊论文]-中草药
2007,38(8)
引证文献(8条)
1.杨秀伟.张建业.钱忠明 罗汉果中新的天然皂苷[期刊论文]-中草药 2008(6)
2.杨秀伟.张建业 应用2D NMR技术研究罗汉果醇及其苷的结构[期刊论文]-波谱学杂志 2007(3)
3.陈瑶.贾恩礼 罗汉果化学成分和药理作用的研究进展[期刊论文]-解放军药学学报 2011(2)
4.张晟.陈祥贵 降血糖植物皂苷研究进展[期刊论文]-中药材 2007(5)
5.肖刚.王勤 罗汉果研究进展[期刊论文]-上海中医药杂志 2006(11)
6.朱靖静.邹坤 葫芦素类四环三萜化合物的研究进展[期刊论文]-三峡大学学报(自然科学版) 2009(5)
7.熊绵靖.唐其.马小军 罗汉果三萜皂苷生物合成规律研究探讨[期刊论文]-广东药学院学报 2011(5)
8.张宏.李啸红 罗汉果化学成分研究进展[期刊论文]-安徽农业科学 2011(8)
本文链接:http://d.wanfangdata.com.cn/Periodical_zcy200509002.aspx