全 文 ：!!!!!!!!!!!!!!!!!!!!
!# $%& ’()
!#$%&’()*+,-./ 01 23 #$#%#4
! 567!#$%&8,-9!#$% &’%#$((%: ;<./12=>0?@ABC DE!FGHIJ
KLMNO’(PQRSLTUV(P>LWX=>&GYZ[\CH]^_L!#$%&8,-;<‘/G
1234Z]abcLde’fgh & ijhGRSklZ]mSnLRSop $ q ’( rp ) q ’( G12
stuvw *$+,’-r .$+.’-xyz{|h}~L12stu ./+#’-r #+#’-C
#$% !F (PQ ,- 1234
&’()* 01.)+%.
’’’’’’’’’’!9)*%+’%,-.% #+,% 2+3455:€‚ƒ„…C†!‡ˆ‰%Š!F3‹&ŒY0
Ž‘’“”•f–—L!F;˜™‘’š›œG=>mUGž*LŸ+ <‹X¡¢
£¤G=>¥(PL^¦§¥¨G©Zª«C!¬V­Z®¯°®±²®³<+V´zY>µ¶w¯·
–¸C¦!‡ˆ3‹‘G‹&ŒYG¹ºL»¼½¾LE¿ÀLÁÂ!ÃÄÅÆÄ‘‡ˆ 6%,’78L
µÅ#Ç‘ ),6%,’’789$:C!Å#‰ÈÉÊ˘ÌÍG=>&ÎL›Ï™ 1 ‘ÐLÑ!ÒÓԏÕ4Ö
×G!Å#ØÙÚLÛÜ#ÝÞf,߉ÛàáGâ&‰Ù<9):C!$%&8ãäå<æ磤G
Žèé9)L%:Lê+æç@ë³<£¤Gì•fŽ¥íîïðC,ñò@ëGóô³<~ÁLõö÷
rGø£ùúûüýCþÿ567!#%Š&=>&Î+,ñ./1234GABLe!#$
GY&Ø%C!%Š&G=>&Îóô&’()*+l&L,ˆHI‰ÉÊ-.®/0.r12.
34(P56L(P>è7L89:®;,?9%:C@AB3C’RSGDEÒ!F
+FGHIJK1234GAB‰L¸¦YZ=L¥MLNYop OÔ§¦_bGPQ 91:C¬RLST
’U!FG(P>LWUVYZ[\L;!g&ŒY–¸V4GªWXYZ[C\]wž^G
±²>Lþÿ_4´‘Û‘>èaGgh®ijh®);/!bc.+de®f‹F <®yz{|h3O’Q
+!%Š&56RSABLTU7%Š&GYZC
! +,-./
!! + ,
gh ijL´Y&RSx
!# klmø‚3noABŒpqr!5ùLstùu =*** Älvwx5‡ˆy‡LŠ;
z{#L5ùC|Õ4NŒYx
O’Qgh®ijh®);/!bc.+de®f‹F <®yz{|hC
!# . 0
}Š$~!#LÆ =>>’8 #Ý’$ =>>’?@ €‚ƒ‰„‚L…f†‡Bˆ‰Š‰L†‡Bˆ‰
‹% %>’?ABL4‰ŒŽ’L‘Š’L“‰”’$ =>>’?@L•–56 ) }‹%Lld’C—
== ‡RSL/ q˜™LO’QÉ© >+=’-LC‹Y’hš+›L,uÜ )>’C?’! =’C? Gœhš‹
fžŸAY’‰‹ ’?ABLŠ§ ¡oƚ¢h >+’78L€ %>’C? ! %>’C?’! 1>’C?G£<¤‰L¤¥‘f
+,ñ;’C? §¨u@©ª‰L«¬ÆO,ñ./­©Ld®RSoÆ ’( G./­
¯’LDEžkG./­©°À12sL°À±²³
12s D9+›k./­´RSk./­:E’+›k./­
* + , - . /
#$%&’& ()*+%,- ). /+)0$,- +)0’
123456 %247
89:45;;7
p 56µ p 7¶
5;;7Ä <5·
¸¹º »L=*// ċL¼CŽ£½³Œ+V4C¾«¿À³>.*.!//.*>>x>%K=/%+CL?
Á»¶³)>>1!>.!)
! ! #$%&’()*+,-./0123456789:
: #$# ;<=>?@ABCDEFGHI %&’( FJ17KLMNOPQRSTUVWXYZ[
\]^_‘ab
! !#$%
WXcd ) efd * e +,-.. gWX23457KLhCQRi]jk .blm . nopSqc *
ehCQRi]krWXYC_[sBtuSvwQx9pWXb
2yz57{LZ[|^|}}tu~TUSi]jm *b m * njS’()*+,€WX12
3‚z5ƒ7{\]tuS € . „WXcd . e +,- 67{L… /012,3S d * e +- 67{L…
+45*6S}†6z57KL‡1ˆ‰6^_[BtuSŠd * e +7- 67KLrt‹ŒSŽpY
‘’“\”•–—ƒŽ˜™ € * „WXcd . e +- ƒ7KL… 8*5+6S d * e +- ƒ7KL…
/2596S7KL[T€ .„šS›r€ * „œ~,ž-S7KL+šSŸ d * e +- ¡¢£Uš
ƒ7KLb¤-0WX¥S¦§¨ : ©ª¨ : ’()*+,\]«¬SWXcd . e +,- fd * e +,-
ƒ7KLQ­s® 8.54,6f /.5/,6S d * e +,- ƒ7KL‡’()+¯,€ * „ƒ*Z /259,6°
±S ¢£Ušƒ“\S nj¤-0²®³´/ƒ./µ¶\9:™45.,6_·¸¹¨ :’()*+,W
Xƒ\]„ºSWXcd . e +,-fd *e +,- ƒ7KLQx… /059,6f 9+59,6™»¼¤-0ƒWXƒ
7KL‡1ˆ‰ƒ^_½¾tub¿EÀÁŽSÂ’()*+,WXƒ€ÃS¾ŠÄ5|ÅÆSÇ 
QÈÉÊËSÌQ‚5ÍÎzÏЀ¦Ñƒ»¼Òh™Çӈ‰ƒ‚5ÔեπÖWb
& . ’()* +*, # $-’(./0123456$%7
×_ØÙ ÚÛÜ
Zhf
Ý .,,,,,,,,,,,Ý *
[ h
Ý .,,,,,,,,,,Ý *
,,,,,,,,,,; Þ
Ý .,,,,,,,,,Ý *
;454+ ;454.
ß A # %&# ’%(( ’%!) ’%’* #%*) (%’’ !%*
!%’+
(%#
!%+’W X ’ %+( ,%)& %+ ’%,) !(%&-- (#%)--
à C #’ !%#+ % ’%’# ’%’!
á×_ *# #%+# )%(+
8 ! 9()* +* !, # $-9(./01234:;<=>?@G@ABCFâ
ã ä W X
5å| <å
Ý .,,,,,,,,Ý *
,7KL <6
Ý .,,,,,,,,Ý *
^_tu~
æ=454+
Ý .,,,,,,,,Ý *
æ=,454.
Ý .,,,,,,,,Ý *
,. ’()*+,€ . „ .+,,,,,,,,,,,28 ,/052,,,,,,,,+45* ,,,>777777777777777? 77@77777777777777@
7* 45.73*A0!çèé1êë 8*7777777777779/ ..5*7777777777459 777B ! $77777777777777$
72 45.73*A0!çèé1êë : ’()*+, .07777777777772! /+5*7777777777+952 777> # @77777777777777@C
7! 45.73ìíî D7GEFâ ..077777777777/07 !45/7777777!.45* 777B $77777777777777$
7+ 45.7GEF7: ’()*+, *4777777777777!! /4527777777777!+52 777> # @77777777777777@
70 ’()*+,€ * „ 8777777777777.2 8*5+7777777777/259 777> $ @77777777777777%
79 45.73§¨ :745.73©ª¨ 8+77777777777794 7785+7777777777.*5. 777B ! $77777777777777$
7/ 45.73§¨ :745.73©ª¨ : ’()*+, ..777777777777.+ 8.547777777777/.5/ 777> $ @77777777777777%
78 45.73_·¸¹¨ .4+77777777777798 !45*7777777777774 777B ! $77777777777777$
.4 45.73_·¸¹¨ : ’()*+, .!777777777777.8 /05977777777779+59 777> $ @77777777777777C%
.. ӈ ..!777777777777/4 774777777777777777774 777B ! $77777777777777$
›rï.5mð5å|… 0 eßAƒZ[ޙ*57€ * „ñ€ . „òócSô€´„ŸòóS»õWX[€ . „b
›rïHH WXY^_Btu
..2
! # $ % & !!
! !
#$%&’()*+,-#./01234567)/8’(9:;&<=>?@< #$ABC
DEF#.& %& GHIJ;K/LM ’(’)*+’,-.*/01/2/3/4/5/6/7/8/9/:A8N ’(’)*+’,-.*/01 &%
OPQ/RSTUV ’(’)*+’,-.*/05 &WXYZ’(P[ #;/<$A=>? \]%@A<^_#.5‘)abcOd
e/fBgh2i 3!!!B3!!C jklmcnopq/r 3!%/3!C/3!%% l8snopq/8’(tu
vwA42&xy(z{|,/=*D\]%@@%^/}~F/€(‚ƒ„/42l…†‡’(ccvw#A$A
deNˆ‰PŠ‹&Œ EŽ‘’“Š6”•–-m[&—0˜7’™7/ šG˜7)™
7›˜7œG—0ž/Ÿ —0ž€’()*&¡6r¢£¤¥N/¦§6a¨/‘©’()*&
¢£/RŒªŽ«¤˜7—0ž/¬­®¯°rN±’()*&¡6r¢£]² 4 2l…†^/
³´µX¶)·ˆ¸&a¨/ŒªŽH¹ºvw¶)& F8 »/º›·¼ ½6)&¾¿G#À
p)N/Áf(&½6)zuÂBFÃÄ’( #%!$AJÅÆǍȷm[&ÉÊ(/€ËÌNÍ:7Ν
&¡¢ž/-m[&Å¡6’/ºÏÐ’()*&¡6¢£/ÑRÀQ8ÒE(Ó!H;!ÔÕn_Ö×&Ø
n€ÙÚNۛl¡6/ÜÝÙÚN&¡AÞSß&ÃÄa¨6”•Š¢àÉ·áÞâA
ãäåæçèéOê %G< ë ./ìçåê &G! ë .Aäíîïðñcò󗨠çåôõö÷/¨
6”øùö÷çåôõ/úûü¨Pýþ&-ÿ6!#’6”ù/«¤ÿ6!€ÙÚNf$6”%
&/’(ÿ6)/*+çåN&ôõ/8,--·./ª0122/345a678K9:/R;Ÿ X
¸ü¨/çåôõ_ÿ6<&Ŷ(f=C>¢?|A@¨#A–è&Œ)(B¶ö÷çåôõº
ÄC6”B¶&iD,-A#.&ü¨_6EFG/H#IA¿JKNLÄMçôõ/NO€P
¨/RaV‘’&ŒªŽ/8ü¨øùQ¨OxRS7æT‘’äíUVW72!<;&!%@@; æ
X‘’nYZ[\&,]/^_Y‘ab6&“Šøù€åæcçN&¨-dRºâ&A#C€ã
ä&efªgfªýhªýiª1j\®kGlm/šVäZ#†f@¨ÀnbÊopqA
#. ]#$#%&’#()*&+ ^
O
OH
O
COOCH3
O
O
AcO
OCH3OOC
OH
O OH
O
H
1
3
22 23
H
O
OH
O
COOCH3
OH
AcO
OCH3OOC
OH
O OH
O
H
1
3
22 23
H
#. ,]-.%/*01&2#$#%&’#()*&+^
%%I
! ! #$%&’()*+,-./0123456789:
! # $
###;<=$’(>?$@ABCDEFGHI$%&&’(%)*’%
+#%###,-./0-12+3$+4556.-.7#85#099:#-0;#<9=6-#60#8>9?.8:60@+18=9?-0.9+85+A=B19==-+C7=8D19==-+ 18+D8:9+.8::80=7+D99;+D712916.+60D9.16.6;9D(+60E+360@2+
F+G+HI2-?6+<+3+JF-29K-#L#M#N91O-=(P4;Q(#R99:#-0;#90>6?:901(#R9S#T9=26E#UC58?;#V+WXY+GBZ=6D260@+I8(G>1([1;(N\\](^&^*^^
OO’OOOJKL(’(+M,1N)OPQRSTUVW/(XY9,Z[N%&&%N%’\!]E_*_’
OO!OOO^_‘(’(abcd)ef:ghE‘ijkla(mnEoDpqrZN%&&&()’*)OO^ OOslt(u(vwxyZz{|}~gh€,UV/(oDpqrZZ[N\\’N!P’QE]!*]OO]OOO[97O3ObO‚T9028=:OLOLO‚c88;OL(Od29O.29:6D1?7O85O-C-;6?-.2160(OR-1(OG?8;(OF9A(‚\\’O\&]E&\*^)
O)OOOF9:Z8=;O YOO‚e2=O 3.2:B119?9?OYO‚LD.29?OMOOFOO3(O h4;Q(+R-1B?-=+G9D16.6;9D+ 5?8:+129+R99:+d?99-0;+U129?+d?8A6.-=+G=-01D(+4D.2Z8?0E+T9B1D.29+i9D9==D.2-51+ 5B?+
d9.206D.29+jBD-::90-?Z961+i:ZYN\_)(%_\*%\_
+_+++ƒ„…(†Q‡,ˆ‡,†Q0(‰ŠEx‹pqGŒIN%&&(^\*_^
+\+++X-=-0;?6+<+,+‚[99+3+<+NM=8./9+k+L(+X6=8@6.-==7+-.16>9+>8=-16=9+8?@-08DB=A2B?+.8:A8B0;D+5?8:+129+D99;D+85+129+099:+1?99N+!#$%&#’()# %*$%’#
P<9=6-.9-9Q(+k(+L@?6.(+,88;+I29:(N+\__N’]P^QE+&!_*+&^!
!#$$%#&’( )**+# ’* ,%#$ )-#$%+# *$’. /. 0%12 3
5#%6&7&8$2 ’( 91&:’2&#&’( ’* !#$% &’%#$((%
!# $#%&’( )&’( !*+&’ ,#’( +-*
./’&+01’( 2 3#45’( 6#’5#786/3/98$&’1:;*8<&’&’ =>?>@>A
;62#$%+# B-C#7D#’54 E#7# D&F# 5; 45*F0 5:# #%%#G5 ;% ’##D +#&% #-57&G5 ;’ F#57#&5;’ ;% ;HC;45;’ ;% +%*,#
-&#*,..# D&(;#4I/GG;7F’( 5; 5:# 457*G5*7&+ G:&7&G5#745G4 ;% &1&F7&G:5’8&FF5H#4 E#7# *4#F 5; 457#’(5:#’ 54
45&J+50 &’F #%%G#5IK#4*+54 ;% 5:# #-C#7D#’54 4:;E#F 5:&5 ’##D +#&% #-57&G5 ’ E&5#7 :&F 457;’( #%%#G5 ;’
F#57#&5;’ ;% ;HC;45;’ ;% +%*,# -&#*,..#I3:# #%%#G5 E&4 5:# J#45 ’ &FF’( C:05G &GF &’F G57G &GF8E5: &
F#57#7&5;’ 7&5# ;% L?IM N &’F O?IO N ’ %745 %H# F&04 &’F 4#G;’F %H# F&04 7#4C#G5H#+0P%;++;E#F J0 #70 5:;7JG
&GF8E5: & F#57#7&5;’ 7&5# ;% OQI> N &’F >=I> N 7#4C#G5H#+0I
<= 3’$>2 &D&F7&G:5’ 45&J+1#7 )%*,# -&#*,..# F#57#7&5;’
^