Abstract:In order to demonstrate the ZJ-2725’s development and application value, the herbicidal activity, spectrum of weed control and safety to crops of ZJ-2725 which belonged to the novel triazolo pyrimidine thioacetamide compounds were carried out by indoor bioassay. The result of dish dipping and pot trials indicated that the IC50 to the test broad-leaf weeds’ root was 0.6994-10.3130mg/L. The IC50 to gramineous weeds’ root was 20.3234-32.2657mg/L. ZJ-2725’s activity spectrum and herbicidal acti-vity were determined by pot trials, the result showed it had a good selectivity. It’s IC50 to the broad-leaf weeds such as Amaranthus retrofle, Chenopodium serotinum, Galium aparine was from 33.8708-40.7437g/hm2 (the active ingredient) by foliage spraying, and to Echinochloa crusgalli, Avena fatua was from 139.4231-277.6613g/hm2. The low relative seedling ratio and fresh weight reduction showed ZJ-2725 couldn’t be used to soil treatment. The result of safety trial showed the new compound was the safest to wheat, the selectivity coefficient of ZJ-2725 was 4.876, and it was less safe to corn, the selectivity coefficient was 3.702, it was unsafe to dicotyledonous plants such as Brassica camperstris, Brassica napus.