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Modeling of thermal degradation of linarin during concentration process

999感冒灵浓缩过程蒙花苷热降解规律研究



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Modelingofthermaldegradationoflinarinduringconcentrationprocess
DENGHaixin1,PANHongye1,CHENZhouquan2,ZHANGYuefei2,WangLonghu1
(1ColeageofPharmaceuticalSciencesZhejiangUniversity,Hangzhou310058,China;
2ChinaResourcesSanjiuMedical&PharmaceuticalCo.,Ltd.,Shenzhen518110,China)
[Abstract] Ganmaolinggranule,withannualsaleofoveronebilionyuan,isthefirstbrandofdomesticcoldmedicinesalesAsthe
onlytraditonalChinesemedicine(TCM)qualitycontrolindicatorofGanmaolinggranule,linarinisthermalyunstableItscontentwil
bechangedsignificantlyduringtheproductionprocess,whichwouldthenafectthequalityofthefinishedproductInthispaper,the
lawofdegradationoflinarinwasinvestigatedTheexperimentalresultsshowedthatdegradationreactionoflinarinbelongstothefirst
reactioncharacteristicsTheefectivemethodstoreducethelossoflinarinwouldberealizedfortunatelybystrictlycontrolingtheheat
ingtemperatureorshorteningtheheatingtime
[Keywords] linarin;concentrationprocess;thermalstability;Ganmaolinggranules
doi:10.4268/cjcmm20160803
  
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