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期 刊 ：中国中药杂志 2007年 32卷 11期 页码：1024.

关键词：丹参酮；微乳；肠吸收；

Keywords:microemulsion, tanshinoneⅡA, intestinal absorption,

摘 要 ：目的：制备丹参酮微乳(Tan-ME),并考察其性质及大鼠在体肠吸收特性。方法：Zetapals多功能电位/粒度分析仪测定Tan-ME的粒度及其分布,原子力显微镜观察微乳粒子形态,建立测定肠回流液中丹参酮Ⅱ_A的HPLC测定方法。结果：Tan-ME乳滴平均粒径为(32.25±6.59) nm,粒度均匀。肠吸收实验结果表明,Tan-ME能促进丹参酮在大鼠小肠的吸收,但Tan-ME吸收速率受Tan-ME水相含量影响较大。结论：Tan-ME制剂能够促进丹参酮在大鼠小肠的吸收,提高丹参酮的生物利用度。

Abstract:Objective: To prepare tanshinone microemulsion (Tan-ME) and investigate its properities and the absorption character in rat intestine in situ. Method: The microemulsions were prepared and characterized using Zetapals Zeta potential/particle size analysis and atomic force microscope. A HPLC method for determination of tanshinone Ⅱ_A in the intestinal flux was established. Result: The Tan-ME was fine droplet with an average droplet size of (32.25±6.59) nm. The results of Tan-ME absorption in small intestinal indicated that Tan-ME could improve the absorption of tanshinone Ⅱ_A in rat small intestine, but the absorption coefficient of Tan-ME, Ka was influenced by the ratio of water-phase in Tan-ME. Conclusion: Tan-ME could improve the absorption of tanshinone Ⅱ_A in rat small intestine. Thus bioavailability of tanshinone was improved.

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