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期 刊 ：中国中药杂志 2008年 33卷 10期 页码：1221.

关键词：黄连；黄连复方；古今临床应用；现代临床新应用；

Keywords:Coptis(Huanglian), compound prescriptions-contain coptis, traditional use, modern application,

摘 要 ：黄连是古今常用中药,有两千年的临床用药史,功能清热燥湿,泻火解毒,用于湿热,热毒诸证,内服外用均可,以黄连为主或配用黄连的复方,如普济消毒饮、黄连解毒汤、朱砂安神丸、清营汤、安宫牛黄丸、牛黄清心丸、交泰丸、黄连阿胶汤,左金丸、当归龙荟丸、黄连羊肝丸,五泻心汤,连朴饮、葛根黄芩黄连汤、白头翁汤、香连丸等名方均以清心肝火热之毒,胃肠湿热之邪为要。现代多认为黄连是抗菌、抗病毒中药,广泛应用于各种感染性疾病,其实在药理研究的基础之上,还应用于心脑血管疾病,糖尿病和恶性肿瘤。笔者也在临床上用黄连为主或配伍治疗上述各种疾病,近年更把重点放在抗恶性肿瘤和肝胆疾病的临床和实验研究上,特别是肝脏疾病方面,观察到黄连及其复方在各种肝脏疾病上,如急慢性肝炎、肝纤维化、肝硬化和肝癌等属于湿热、热毒证者,辨病与辨证相结合,效果明显,部分结果已经得到实验研究的证实,值得进一步研究开发与应用。

Abstract:Huanglian is a commonly used Chinese medicinal herb in the ancient and the present.It has a history of 2000 years in clinical application,having the efficacy of "Clear away heat and remove dampness,purge the sthenic fire and eliminate toxic materials",therefore can be used for various diseases or syndromes in types of dampness-heat and fire-toxin by internal or external use.Compound prescriptions mainly based on Huanglian or prescribed by Huanglian,such as Puji Xiaodu Yin,Huanglian Jiedu Tang,Zhusha Anshen Wan,Qingying Tang,Angong Niuhuang Wan,Niuhuang Qingxin Wan,Jiaotai Wan,Huanglian Ejiao Tang,Zuojin Wan,Danggui Longhui Wan,Huanglian Yanggan Wan,Wu Xiexin Tang,Lianpu Yin,Gegen Huangqin Huanglian Tang,Baitouweng Tang,Xianglian Wan etc.All of these are well-known formulas for clearing away toxin of heat-fire of heart and liver,as well as dampness-heat of stomach and intestines.Nowadays,Huanglian is generally considered as a kind of antibiotic and antivirus herb and is widely used for many infective diseases.In fact,it is also used to cure cardiovascular and cerebrovascular diseases,diabetes and cancer based on pharmacological studies.Having been using Huanglian in treating the above diseases and having conducted clinical and experimental research on cancer and liver diseases,the author observed that Huanglian and its compound prescriptions have obvious effects on liver diseases such as acute or chronic hepatitis,liver fibrosis,liver cirrhosis and liver cancer due to types of dampness-heat and fire-toxin.Part of the effects has been proved by experimental research and it is worth carrying out more research in this area for development and clinical application.

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