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期 刊 ：中国中药杂志 1998年 23卷 06期 页码：375.

关键词：黄连；黄芩；甘草；抑制金黄色葡萄球菌生长；配伍；

Keywords:Coptis, Scutellaria, Liquorice, growth inhibition of Staphylococcus aureus, combination,

摘 要 ：以ＭＩＣ相对值为指标，观察黄连、黄芩、甘草煎液单味或不同比例配伍后对金黄色葡萄球菌生长的抑制作用。结果显示：黄连与黄芩配伍，黄芩的抑菌作用有所降低，但黄连则未见降低；黄芩多于黄连时，黄连的抑菌作用似有增强。黄连与甘草配伍，无论比例如何，配伍后的抑菌作用均呈降低趋势。当三药同时配伍时，黄连、甘草的抑菌作用不变，或反增强，只有黄芩的抑菌作用有减弱趋势。黄连与黄芩、甘草两两配伍，单独使用时，其抑菌作用似不如组成三药配伍。其机制值得进一步研究。

Abstract:Using MIC as relative index,an observation was made on the growth inhibition of Staphylococcus aureus by Coptis alone or in combination with Scutellaria and or liquorice. The result shows that when Coptis is combined with Scutellaria,the bacteriostatic effect gets weaker for Scutellaria,but remains unchanged for Coptis,and when Scutellaria takes greater percentages in the combination,the effect of Coptis seems to be stronger.When Coptis is combined with liquorice, whatever the respective percentages may be,the effect tends to get weaker. When the three drugs are used in combination,the effect remains unchanged or even gets stronger for Coptis or liquorice, but fends to decrease for Scutella ria.Coptis used singly or in combination with Scutellaria or liquorice is inferior in bacteriostatic effect to the combination of the three drugs.The mechanism is yet to be further studied.

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