Abstract:A test was made on the effect of rotundine on the secretion of gastric acid and pepsin activity in rats.Copared with the control group,rotundine(≥17.1mg/kg)inhibited gastric acid and decreased secretion of gastric juice(P<0.01),but had no influence on pepsin activity.There was a negative relationship between total acidity and pH of gastric juice (r=-0.9818).