Abstract:The agar-dilution methdwas adopted to study contrastively the bacteriosttisis of Rhizoma Coptidis and TMP,andalso of the two drugs in combination. The results indicate that the combination works in good coOperation against Es-chaichia coli,Bacillus pyocyaneus,Staphylococcus aureus,Shigella flexneri and S.dysenteriae.