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期 刊 ：中国中药杂志 1995年 20卷 09期 页码：539.

关键词：蟾酥；脂蟾毒配基；透皮吸收；丙二醇；Azone；

Keywords:Venenum Buforus, resibufogenin, percutaneous absorption, 1, 2-propanediof, azone,

摘 要 ：以V-C扩散池和HPLC检测法,研究丙二醇和Azone对蟾酥的透皮吸收影响;并对脂蟾毒配基进行了HPLC定量检测。结果表明:丙二醇能明显增强脂蟾毒配基的透皮吸收,Azone能明显缩短其透皮时滞。

Abstract:V-C horizontal diffusion cell and HPLC determination have been utal to study the effect of 1, 2-propanediol and azone on the percutaneous absrption Venenum Bufonis the contents of resibufogenin have been deter-nnned through mouse skin in vitro by HPLC. The results indicate that the contents get increased when 1, 2-propanedi-ol is added and that azone can shorten the lag time of percutaneous abasorption of resibufogenin through mouse skin invitro.

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