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期 刊 ：中国中药杂志 1989年 14卷 06期 页码：50.

关键词：大黄；环核苷酸；解热药物；体温；

Keywords:Rheum tanguticum, cyclic adenosine monophosphate, antipyretic analgesics, boby temperature,

摘 要 ：用放射性免疫测定方法,检测大黄对家兔体温中枢附近脑室灌流液内环核苷酸(cAMP)的影响,结果表明,大黄使感染性发热家兔cAMP水平降低,而对正常不发热家兔cAMP水平没有影响。对照组动物cAMP水平没有变化。提示大黄降温作用机理之一是通过影响中枢cAMP水平而实现的。

Abstract:Rabbit model of fever was produced by means of subcutaneous innoculation of pneumocci.Third ventricular intubation and irrigation were carried out in rabbits. Irrigation fluid was collected during the stage of normal temperature, at the peak of fever and when the temperature was lowered by rhubarb, cAMP was detected with RIA in each of the three portions of the irrigated CSF. The result showed that cAMP level was raised during fever and decreased after rhubard administration. Irrigation of CSF without medication had no significant influence on cAMP level.

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