免费文献传递   相关文献

Effects of Xiangsha Liujunzi decoction on TLR signal pathway in gastric mucosa tissues of rats with Helicobacter pylori-induced chronic atrophic gastritis

香砂六君子汤对菌致慢性萎缩性胃炎TLR信号通路的影响



全 文 :1$#
z

{ ­
&
®­
#
~
W-Db&$ ;-b# 3BXBAF$ 1$#

hi)(
#!1$#4$54$

jklR
#!
7|?8ÛÔDSMN
1$54##%
»x}8Ûû1eDS%&
1$414($#

mn?o
#!
!
¯ßà
!
«‡NVR
!
STbwUÈÛVt
%NTD$5(()#&$)#!L4.@ED$DE0]GEaE@0X5#1$$$2#5b,-.
Cz{|öaá}~Ԁԁ‚
NI>
w<@Nƒ()
¯ßà

!
!
X‰á
1
!
âãã

!
äåæ

b
»x`D‰t ÜÝ7|9Ã`a V¯D
!
»x 7|
5#1$$$%
1b
»x`D‰t ÜÝ7|9Ã`a :;!
»x 7|
5#1$$$#

rs
#!
Ԓ“Cz{|öas7ÍáÕÖԁ‚
!H3Z
+fƒÐœ
N-D
¬z®
!N-DDE^TCT,TRF-CA$NI>
w<
@Nƒ()
(
ñ
#$
P6Z½ƒ
8K
+f¡f‹Ô
#
i
#
ô+¦i
$
̯i
$
Cz{|öai
!
Ÿ

$

þrF
5
i

ڜåž
r
!8[1$5($
i
(
@8%‘s7Íá
!H?
*çº~Ԁԁ‚̯
(
ij¨wøG]‘ijƒ¨MDE
)LI:83
øG
N;P4

$:I4#
‡Fڜ
E;O8
ƒÓÔ
)
X¿Tc¶Gæ
;O
ƒ‡F
)M?<>$`TAFTC04QD-F
øG]‘ij
NI>1$NI>&$
?593?f$;P4
2
[
ŽƒÅÆDE
(
æYý›
$
+f̯i¹ô+¦iՉ
$
]‘ij
NI>1$NI>&$R4?593?f
m<ڜ
ž…8
;P4
2
[
m<ÅÆôŸ†
!=t$b$)
¹Ì¯iՉ
$
Cz{|öai+f]‘
NI>1$NI>&$R4?593?f
m<ڜ
ž…8
;P4
2
[
m<ÅÆæç,Ÿ
$
ÚþrFi,ŸeÔàý
!=t$b$$
Ù
H?
큔æç#þ

~Ԁԁ‚ƒ¨wM
_æç#±
(
æYÅà
$
+f̯$
$H?
@8pÓ
NI>1$NI>&=93?f=;P4
2
[=E;O8=;O
w<@N»m~Ԁԁ‚ƒ
¨woM
$
Cz{|öaí
H?$
ð#±
H?
Åƃ~Ԁԁ‚ƒ]‘‚Ƶ”
(
–$,µrŽ
H?
“}ƒ~Ô
€Ô‚’Ÿx¬BÐ
(

tuv
#!
Cz{|öa
)
s7Íá
)
~Ԁԁ‚
) N-D
¬z®
)
…ö
^@RR@[) ?5
j¹cÓ_m*87F1:28\.-4M:6- S.>W>4R.07F2F1.2424CS9:.M4-/;-16P-@ .4M-:13.F
,>F2:- 1.::>7:283-1:P.16;)5,3%5+2<9),2+.40>F70
F6324.F-132;6.FM-:13.1.:
I:;YGE4aE@0X

!
$ `3;ZK@47B@0
1
$ HO;Z8G@04AG@0

$ P_SE046@0X

!bA*>-/.;*).$&=#-/;-6$ .#*N(/+.L$+>(.-%$&Q8-)P#$8 <&(%(-.*0 .$N82(-) ,*0(-%4)(5*/+(.6$
Q8-)P#$8 5#1$$$$ #()-) 1bA*>-/.;*).$&7*+>(/-.($)$ .#*N(/+.L$+>(.-%$&Q8-)P#$8 <&(%(-.*0
.$N82(-) ,*0(-%4)(5*/+(.6$ Q8-)P#$8 5#1$$$$ #()-
*B<:13-F1+!N-T7RD-CTFGTT\T,FA@0U .T,G@0EA.-\SE@0XAG@IEB/B0]EUT,-,FE-0 -0 NI>AEX0@DR@FG*@6E0 X@AFCE,.B,-A@FEAABTA-C@FA*EFG L*%($9-.*/>6%$/(4CTD@FTU X@AFCEFEA$AE7F68KC@FA*TCTC@0U-.D6UEdEUTU E0F-,-0FC-DXC-BR$.-UTDXC-BR$ GEXG ,-0,T0FC@FE-0 -SE@0XAG@IEB/B0]EUT,-,FE-0 XC-BR$ .-UTC@FT,-0,T0FC@FE-0 -\SE@0XAG@IEB/B0]EUT,-,FE-0 XC-BR$ D-*,-0,T0FC@FE-0A-\SE@0XAG@IEB4
/B0]EUT,-,FE-0 XC-BR @0U 8[1$5($4FCT@FTU XC-BR$ *EFG $ C@FAE0 T@,G XC-BRb8KC@FA-\HR4@AA-,E@FTU ,GC-0E,@FC-RGE,X@AFCEFEA.-U4
TDA*TCTTAF@QDEAGTU Q6E0FC@X@AFCE,X@d@XT-\L*%($9-.*/>6%$/(!H? ABART0AE-0bQ6GEAF-R@FG-D-X6bLI:83*@A@RRDETU F-UTFT,FFGTT7RCTAAE-0A-\N;P4

@0U :I4# E0 FGTATCB.$@0U FGT@,FEdEF6-\E;O8 E0 X@AFCE,.B4
,-A@bNGT,-0FT0F-\;OE0 FGTX@AFCE,.B,-A@*@AFTAFTU Q60EFC@FTCTUB,FEdTT0]6.@FE,bNGTT7RCTAAE-0A-\NI>1$ NI>&$ ?593?f$
;P4
2
[*TCTUTFT,FTU Q6M?<>@0U `TAFTC04QD-FbNGTCTABDFAE0UE,@FTU FG@FFGT,DE0E,@DA6.RF-.A-\C@FA@0U R@FG-D-XE,@D,G@0XTA-X@AFCE,.B,-A@*TCTE.RC-dTU E0 SE@0XAG@IEB/B0]EUT,-,FE-0 XC-BRb<-.R@CTU *EFG 0-C.@D,-0FC-DXC-BR$ FGTRC-FTE0 T7RCTAAE-0A-,%$5,
5.§Ï
#
Cz{|öaá}~Ԁԁ‚
NI>
w<@Nƒ()
NI>1$ NI>&$ R4?593?f@0U ;P4
2
[E0 X@AFCE,.B,-A@-\.-UTDXC-BR C@FAE0,CT@ATU !=t$b$ *EFG FGTDTdTDA-\N;P4

@0U :I4
# E0 FGTATCB.$ @0U FGT@,FEdEF6-\E;O8 @0U FGT,-0FT0F-\;OE0 X@AFCE,.B,-A@E0,CT@ATUb<-.R@CTU *EFG .-UTDXC-BR$ FGTT7RCTA4
AE-0AUT,CT@ATU E0 SE@0XAG@IEB/B0]EUT,-,FE-0 XC-BR$ TART,E@D6E0 FGTGEXG ,-0,T0FC@FE-0 -\SE@0XAG@IEB/B0]EUT,-,FE-0 XC-BR!=t
$b$$ *EFG XC@UB@D6E0,CT@ATU C@FT-\H?TC@UE,@FE-0 @0U UT,CT@ATU R@FG-D-XE,@DXC@UTA-\,GC-0E,@FC-RGE,X@AFCEFEAbNGTATCB.DTdTD
-\N;P4

@0U :I4# UT,CT@ATU \C-.!1&b55 q1b1#
3
X,I
i
F-!(b)( qb15(
3
X,I
i
!=t$b$ @0U \C-. !%%b&# q
b$)(
3
X,I
i
F-!55b($ q1b(51
3
X,I
i
!=t$b$$ @0U FGT@,FEdEF6-\E;O8 @0U FGT,-0FT0F-\;OE0 X@AFCE,.B,-A@UT4
,CT@ATU \C-.!b(5$ q$b1$# _,.X
i
F-!$b$1 q$b$) _,.X
i
!=t$b$ @0U \C-. !$b)$% q$b$51 ..-D,X
i
F-
!$b55( q$b$1# ..-D,X
i
!=t$b$ @\FTCFGTFCT@F.T0F-\GEXG ,-0,T0FC@FE-0 -\SE@0XAG@IEB/B0]EUT,-,FE-0b3DFGTT\T,FAE04
,CT@ATU *EFG FGTE0,CT@AE0XU-A@XT-\SE@0XAG@IEB/B0]EUT,-,FE-0 \C-.$b51& X,.X
i
F-b1)# X,.X
i
bNGTRC-FTE0 T7RCTAAE-0A-;P4
2
[UT,CT@ATU E0 FGTX@AFCE,.B,-A@@\FTCFCT@FTU *EFG ?593?fART,E\E,E0GEQEF-C48[1$5($b:0 FGTC@FA.-UTD$ H?E0\T,FE-0 CT4
ABDFAE0 ,GC-0E,@FC-RGE,X@AFCEFEAFGC-BXG FGT@,FEd@FE-0 -\NI>1$ NI>&=93?f=;P4
2
[=E;O8=;OAEX0@DR@FG*@6bSE@0XAG@IEB/B0]E
UT,-,FE-0 ,@0 TC@UE,@FTLb>6%$/(@0U @DTdE@FT,GC-0E,@FC-RGE,X@AFCE,.B,-A@DE0\D@..@FE-0bNGTFCT@F.T0FEAT\T,FEdT@0U A@\TF-
,BCTH?4E0UB,TU ,GC-0E,@FC-RGE,X@AFCEFEAb
* 7^@ P230:+!SE@0XAG@IEB/B0]EUT,-,FE-0) L*%($9-.*/>6%$/() ,GC-0E,@FC-RGE,X@AFCEFEA) NI>) ;P4
2
[) ?593?f
02.#!(_%&)DFWF,,(!&!&V
!!
~ԁ‚
!,GC-0E,X@AFCEFEA$ \á

¨û
8à€¥BãäԘ¨ÏÈɨÅƃyB~Ô
]‘‚Ô¨M
$
\[B+:¨
$
m¨”yB
¨$w‡s
(
s7Íá
!L*%($9-.*/>6%$/($ H?
8à\ÒÓm¨»t[
*+
(
Cz{|öa>
¥
%
©ÜgAµš
&$
ßPAÕ֒“Åà
*1+
$
C
z{|öaåž]‘qù

­SϨwM_
$

]‘™šBúŸ¥ÐƒÐ
$
ðè锑^£
¤˜¨ƒŽ
(
~ԁ‚ƒŽ›‘¹åž
H?
8àBÖ
*54&+
$
h“
H?
8à“¼}ƒ~Ô
‚ðáBÀ+wPƒÐ
(
s’“,‘
H?
“
}~ԁ‚+f̯q˜Cz{|öaá}~Ô
‚Ž›‘
$
&·™
NI>
w<@Nƒ()
$
€!›‘fž
$
ڍԝ§¨Ž
H?
8àƒ~
ԁ‚#$(î
(
! N
ðº
6Z½
8K
+f
#$
P
$
«ðy4
$
®ÊÌ
1$$ X$
°¥CHhÁÃÆJq…BCt«DE
$
)ð<
87
1$14$$$1(
+ft7M7Ùæ
$
ÆJ
q…ƒž›Rêq…jwÓË
(
áB%‘%pè
]á,s7ÎÍá
HR 3N<<&5($&$
¯°Ô
y
$
)
,\B,.I
i
ƒ
H?
þÛî
(
Cz{|öa‘¬Ï
# X$
<)
1 X$
uS
1 X$
Š&b1 X$
ÖØ
&b X$
45
# X$
_C
&b1 X$

&b X
†gòŠ
$
,ð)©9$A,’“ô#$
(
e
›åæA
$
K[)+ºA&+_‡ÿC­[A
ô,r&²‘v,fvž
(
NI>1!%15#443?$NI>& !)443?$;P4
2
[!$%&(443?
—®°¥ï%
RC-FTE0FT,G
DE
)
!
4@,FE0 ! &)#% $ HEAF-0TH5 ! &&)) $ R4?593?f
!&(N$?593?f!#)$?
°¥ï%
<8N
DE
)
»
¼¯[[_ØêÂ
!;O81
øG–r8
$
STMǏ
ö
!N;P


øG–r8
$
<¦E
#!:I4#
øG–r
8ô°¥2þíCÊDE
)
Ý[[_ØøG–r8
$
ž¹ij¹·î
$
ž…m<¹žtm<”#
–r8ô°¥wã/ʅ()DE
)8[1$5($$
x
<
85$%49Z! 8EX.@
DE
$
ï%
) NCE]-D
–r
!N@^@C@
DE
$
|s
)
LI‚–r8
$
x<
>>$&%3
!N@^@C@
DE
$
|s
)
%ÐæF
?<>
–r8
$
x<
K>>1$3!N@^@C@
DE
$
|s
(
4îl
$
²Í¤}äSf
!LRRT0U-CDE
$

%
)9BDFEA^@0 9f5
Âè>
!NGTC.-
DE
$
ï%
)
WE3%
ÆO%ÐæF
?<>
>Ÿ>
!3[:
DE
$
ï
%
)
²6UŠ>
$
I‘>
![E->@U
DE
$
ï%
(
N
µ¶
[!N
‹i¹mÌ
N
ñ
#$
P
8K
+f¡f‹Ôô+
¦i
$
̯i
$
Cz{|öai
!
Ÿ

$

þrF
5
i

ڜåžri
(
}i
$
P
$
«ðy4
(
ô+
¦inÊwÔ­*ø
$
÷yiŽ+f%‘
<@X3
n
è]á,ŸnJV*
( H?
þÛîrF
b( .I=
P
$
¡|

ƒ
$
Ñ
5
ƒ
(
*@
1& G
y6
$
*A
& G
ô+Ÿ6
( H?
8àæ„
1
ÎA
$
}i¡
fî-
1
P+frÇAŸn]‘ijƒ¨w’
ڜ
H?
67
(
,)%$5,
1$#
z

{ ­
&
®­
#
~
W-Db&$ ;-b# 3BXBAF$ 1$#
[N
Û,œ-¬
N
l­m̊lA
$
ô+¦
iøƒyi+fnՔƒÛ,rw
(
yB,…*
®ä0}P
( .I,^X
i
ÿ
(
Cz{|öai
Ÿ

$

þrF‡Ê,‹ŽÔ
$b51&$$b#&$b1)# X
,^X
i
$
}/
1
ƒ
$
ÑÛ,
&
Î
)8[1$5($
Û,F
$
.X,^X
i
$
}
5 U
ƒ
$
ÑÛ,
&
Î
)
ô+¦iÛû
ՔrFƒÊwÔ­
(
Û,ÔA
$
GzÀ{rÇ+
f
$
|¸¦Æ-ù
(
ÉO
$
»-N7]‘ij
$

x^îØ$åq
$
÷¬x7#YæA‘¨wø´
(
[VNH?
67œåæ
!H?

5% w
;É[M7$6
7
!(jO
1
$$j1
$(j;
1
$
‘HBM틋‹
ä
$
HBAq˜‹äÐY
$
øԍŸnWPŸá
(
@
8q˜á†Nß
$
>à/ڜ/EÂ

8[_Ö
Â

[_–JŸná,åæ
(
R_L6`Ø}–
Já†ïßZ‡Ð¨
$
>à/jÔ

/EÂÆJø
Ô

8[_ÖÂÆJøÔ

[_ÂÆJøÔ
$
ÚCx
1RêÔ
H?
øÔ
(
67Ž%‘ê¢èS¢Õ6

(
ÕÖg›)AôøJ&*zŠ
(
[%NLI:83
øG
N;P4

$:I4#
‡Fڜ
E;O8
ƒÓ
Ô
!
-ùA
$$$ C,.E0
i
äS
1$ .E0$
-C6@ð
øG
N;P4

$:I4#(
N7]‘ij¼Cót
$
žy
¢ƒótî^
( $$$ C,.E0
i
äS
( .E0
A-C6
@ðøG
E;O8(
q•0¦
LI:83
–r8ƒõàr
ŸnAž›
(
[#NM?<>
øG
NI>1$NI>&
w<@NÕ֎
.>;3
ƒÅÆ
!
îØ$-Oijù
$
’fA†~
NC4
E]-D
¹·ijž
$
Úª-ƒ
.>;3
ÔÌLLI‚
Ô
,K;3$

,K;3
ŸnÆO%ÐæF
?<>
øG
(
ÚCž›ôq•0¦–r8õàrŸn
(
yŽÅ
…=?:Å
(
Å
!
ÆO%ÐæF
?<>
øGƒÕ֎Å…
N@QDT!?CE.TCA\-C>T@D4FE.T\DB-CTA,T0FaB@0FEF@FEdT?<>
Ž CÐŅ
!(g45g
ÎÐŅ
!5g4(g
Z3?KH <<3<<<3NZZ<333NN<< NZZZ3NNN<<3NNZ3NZ3<33Z
NI>1 333NI>& Z33NZ3ZZ3;P4
2
[ NZ3NZ3<3N3?593?f Z<33<[&N`TAFTC04QD-F
¶øG
NI>1$NI>&
w<@NÕ
֎m<ƒÅÆ
!
-
$$ .X
ijù†~î؍
‹’fA
$
†~‡m<ÂåžržÚ¿Âåžrƒ
m<¹·î¼C¹·
5$ .E0$& w 1 $$$ C,.E0
i
äS
5$ .E0
-C6Gm<¯°
(
$
$
#-Ým<
‘^øG !
4@,FE0$ R4?593?f$?593?f$NI>1$
NI>&
m<ƒÅÆ
$
#-ž…‘^
;P4
2
[$HEAF-0T
H5
m<ƒøG
(
›¥m<®äžC¬FA
$
e
$j e1j 8K8 ?3ZL

$
I‘÷
?WKP
‘C
$

5j [83
$d¾
G$

!} $$$
ª½A
& w
Ä
c8˜
$
±‘A°‘
H>?
Ô*ƒÖ—ÎqÄc
G(
±‘AúÎ$†
LmÐî~Ð
(
[$N
X¿Tc¶Gæ
;O
ƒ‡F
!
N7]‘
ij¼Cót
$
†~ž¹ij¹·î
$$$ C,
.E0
i
äS
1$ .E0
A-C6@ð0¦Ý[[_Øø
G–r8ƒõàrøG
;O
ƒ‡F
(
[)N
K‹Ç
N

8?88 )b$
ŸnK‹
Ç
(
F°ºÚ (
Bq+
ś
$
=°ºÚ”€çŠ‰
ś
)
F°º%‘؏Eµk‹Ç
!O0T4`@63;O4
W3
‘^•iuƒ‰Š
)
=°º%‘
PEAGTC
!lÉ
”¶øJ
( =t$b$(
­ÔklBKdd
(
VN
æY
V[!N
Cz{|öa̯q…[èDEƒ()
N
mÌ@yi+fÓq

!åô+
$
6‡Æ
$
‰møq
ô+
$
+{ô+
(
mÌA
$
+f®Êæç#±
$
Óq
$
$
!åÆ
$
6‡Î,
$
‰mE֏€
$
+{ñªÈ
³
(
Ûû,…
$
+f!å

Óq

6‡æ灏
$
؉
æçAÄ
$
®Êæ矆
$
$Cz{|öaiÚþ
rFƒÐeÔàý
(
òbŽƒÌ¯i+f[è
DE on
(
V[N
Cz{|öaij¨wœ
H?
æ„DE
ƒ()
!
mÌAô+¦iƒij
HL
à/ô
+
$
bøGÞ
H?)
÷yiƒ¨wæYý›]‘
CØw™

º®M

§?ûò

®ä€:

ð:•F
ƒ‚Ɲž¹®
$H?
67æYôÔøÔ
(
yiÛû
Ք,…*ŽA
$
]‘C؃À†

º®ƒ§
,$$5,
5.§Ï
#
Cz{|öaá}~Ԁԁ‚
NI>
w<@Nƒ()
?

€DEڜ‚Ɲžƒ¹®BÈÉ9°ƒo
n
$
$Cz{|öai¡|,…rFƒŸþ]
‘€œ‚ƃon9°ç+àý
$
$þrFi
ƒ]‘Žsô+
$
:q
(
Û,ŽAyiƒ
H?
æ„DE:Å
1$
¹Ì¯iՉ
$
Cz{|öa
þrFi
H?
큔àýŸþ
!=t$b$)
Ù¡|C
z{|öaŽrFƒŸþ
$H?
큔Ô
&=
!($j$(=!#1b(j$=!$$j$
ïßCíƒ+
:
$
‡kl Kdd
)
ò̯i¹åžriՉ
H?
愔 kl
(
3b
ô+¦i
)[b
̯i
)åžri
)KePb
Cz{|öaŸ

$

þrFi
(
q
!
Cz{|öa]‘ij
HL
à/ƒ()
! y$$
PEXb!L\T,FA-\SE@0XAG@IEB/B0]EUT,-,FE-0 -0 X@AFCE,.B,-4
A@DFEAABTHLU6TE0XE0 C@FA! y$$
Å
1!
Cz{|öa]‘
H?
æ„DEƒ()
N@QDT1!L\T,FA-\SE@0XAG@IEB/B0]EUT,-,FE-0 -0 H?,-D-0E]@4
FE-0 E0 X@AFCE,.B,-A@-\C@FA j
‹i
H?
큔
ô+¦
i
̯
$
Cz{|öaŸrF
($
Cz{|öa$rF
#1b(
Cz{|öaþrF $$

åžr
$
!!
{
#
¹Ì¯i‰Š

=t$b$(
V[VN
Cz{|öa]‘ij
E;O8
ÓÔ
;O
‡
Fڜù6
N;P4

$:I4#
‡Fƒ()
!
¹ô+¦i
Չ
$
̯i
E;O8
ÓÔ
;O$N;P4

$:I4#
‡FàýŸ
†
!=t$b$)
¹Ì¯iՉ
$
åžri
E;O8
ÓÔ

;O$N;P4

$:I4#
‡Fô,Ÿ
!=t$b$)
¹Ì¯iÕ
‰
$
Cz{|öai¡|ŽrFƒŸ+
$E;O8
Ó
Ô
;O$N;P4

$:I4#
‡Fæç,Ÿ
$
$ÚþrFi
¹Ì¯iƒkleÔàý
!=t$b$$

5(
V[%N
Cz{|öa]‘ij
NI>1$NI>&$
?593?f$;P4
2
[.>;3
Åƃ()
!
̯i
NI>1$NI>& .>;3
ÅÆàýþ^ô+¦i
!=t
$b$)
÷yÛ,i
NI>1$NI>& .>;3
ÅÆàý
Ÿ^̯i
!=t$b$()
Cz{|öaþrFi
NI>1$NI>& .>;3
Åƹô+¦iu K
kl
)
ò
?593?f$;P4
2
[.>;3
ƒÅÆFyi
uôb:àýKkl
$
:q
1(
Å
5!
Cz{|öa]‘ij
E;O8
ÓÔ
;O
‡Fڜù6
N;P4
8
$:I4#
‡Fƒ()
N@QDT5!L\T,FA-\SE@0XAG@IEB/B0]EUT,-,FE-0 -0 E;O8 @,FEdEF6@0U ;O,-0FT0FE0 X@AFCE,.B,-A@$ ATCB.@DN;P4

@0U :I4# ,-0FT0F
-\C@FA
‹i N;P4

=
3
X,I
i
:I4#=
3
X,I
i
E;O8=_,.X
i
;O=..-D,X
i
ô+¦
1b)% q$b)%% 55b1 q5b$# $b%&# q$b$# $b1($ q$b$1
̯ 1&b55 q1b1#

%%b&# qb$)(

b(5$ q$b1$#

$b)$% q$b$51

Cz{|öaŸrF 1b)5 qb(5
1
#5b$ q&b(%5
1
b1%% q$b$)
1
$b1 q$b$&&
1
Cz{|öa$rF b&& q1b%
1
&%b(#& q&b%#
1
b$%5 q$b$%(
5
$b%(% q$b$1
5
Cz{|öaþrF (b)( qb15(
5
55b($ q1b(51
5
$b$1 q$b$)
5
$b55( q$b$1#
5
åžr #b$1( qb1#(
5
&$b15 q&b$1
5
$b%( q$b$%
5
$b15 q$b$
5
!!
{
#
¹ô+¦iՉ

=t$b$)
¹Ì¯iՉ
1
=t$b$($
5
=t$b$!
q
1 e&
É
(
V[# N
 ] ‘ i j
NI>1$ NI>&$ ?593?f$
R4?593?f$;P4
2
[
m<ÅÆFƒM_
!
̯i
NI>1$NI>&$R4?593?f$;P4
2
[
m<ÅÆFàýþ
^ô+¦i
!=t$b$)
÷yÛ,i$
$
Cz{
|öai¡|Û,rFƒŸ+
$ NI>1$ NI>&$
R4?593?f$;P4
2
[
m<ƒÅÆæç,Ÿ
$
ÚþrF
ieÔàý
$
ŠÌ¯iym<ÅÆàý,Ÿ
!=t$b$)
ym<ÅƐCz{|öaþrFi
,$5,
1$#
z

{ ­
&
®­
#
~
W-Db&$ ;-b# 3BXBAF$ 1$#
!!
q
1!
yi]‘ij
NI>1$NI>&$?593?f$;P4
2
[.>4
;3
ÅÆF
PEXb1!L7RCTAAE-0 -\NI>1$NI>&$?593?f@0U ;P4
2
[.>4
;3E0 X@AFCE,.B,-A@-\C@FAE0 T@,G XC-BR
¹ô+¦iu Kkl
)
ò
?593?f
m<
ƒÅÆFyiuôb:àýKkl
$
:q
5(
b
ô+¦i
)1b
̯i
)5 e(b
Cz{|öaŸ

$

þrFi
(
q
5!
yi]‘ij
NI>1$NI>&$?593?f$R4?593?f$
;P4
2
[
m<ÅÆF
PEXb5!L7RCTAAE-0 -\NI>1$ NI>&$ ?593?f$ R4?593?f
@0U ;P4
2
[RC-FTE0 E0 X@AFCE,.B,-A@-\C@FAE0 T@,G XC-BR
V[&N?593?f
ƒnlÔåžr
8[1$5($
]
‘™šÕÖm<
?593?f$R4?593?f$;P4
2
[
Å
ƃ()
!
åžri
R4?593?f$;P4
2
[
m<ÅÆ
FàýŸ^̯i
!=t$b$$
¹ô+¦iu 
àýkl
$
ò
?593?f
m<ƒÅÆF
5
itu
 Kkl
$
:q
&(
b
ô+¦i
)1b
̯i
)5b
åžri
(
q
&!8[1$5($
]‘ij
?593?f$R4?593?f$;P4
2
[
m<ÅÆF
PEXb& ! L\T,FA-\8[1$5($ -0 T7RCTAAE-0 -\?593?f$
R4?593?f@0U ;P4
2
[RC-FTE0 E0 X@AFCE,.B,-A@-\>@FA
%N
™š
H?
æ„^]‘
$
ð6H™š]‘CØ
$
Ù
ÍÅƝž‚Əöƒ¦Ê
$
\¼}~Ô€Ô
‚ƒÊÓc
*(+
( H?
8àÅƃ‚ÒÓL—
H?
,…ŸnŽ
$
©%Ã~+F§¨’“Åà
$
$
,
H?
8àÕÖԘ¨áBýxƒ§¨Ð
$

${|öa\ÒÓ²‘ƒµr
*#4%+
(
s’“Åà
$
C
z{|öaðÚon+f~Ԁԁ‚̯ƒÆ
×
$
@8í
H?
Üò#±]‘ijƒ™U
(
N-D
¬z®
!NI>A
›Ôf®YBãäƒiŠ

$
ÍÕnlF¨Ž¨c®ÕÖÌ͋ö
!?3?9$
—;ʅ8àã䵔$m~Êӛ
‘
( H?
8àA
$H?
ƒS•–
!I?8
3ðÚÜÌÍ
¨Žz®
N-D
¬z®
!N-D4DE^TCT,TRF-C$N>I
¨Ž
$
nlÔæê
N>I$
™òÓ_ÎÐ
93?f$
¼}
;P4
2
[
ƒpÓ
$
ÜòpӂƝžöÅƁ]‘™
š
*+
(
s’“Æ
$H?
@8C³
N>I1$N>I&

ÎЃ
93?f=;P4
2
[
w<@N
$
Üò²
E;O8
#_
ʊƒ
;O
٠
$
eÅƁ]‘Oß~Ô€Ô
‚ƒoM
)
òCz{|öaðÚê“
H?

93?f=;P4
2
[
w<@NƒpÓ
$
²~Ԁԁ‚
,1$5,
5.§Ï
#
Cz{|öaá}~Ԁԁ‚
NI>
w<@Nƒ()
ÝڎÐ
$
Ù2B›‘\@8
H?
ƒ6Híò
Æß
(
Cz{|öa—
H?
BЃDEÎ
$
þ
rFiOß.
$$j
ƒí”
(
ýä
$
§¨ƒÕÖ
’“$ðqò,ƒDE
$
ÈÉM®tu8àƒ
H?
á,Bkl
$
 ¶Æß
$$j
ƒí
)
s’“%
‘ƒ3N<<&5($&
s7Íáá,ŸnK[m
Ì
$
‹å.i8
$
î÷\iuƒ<ÉÔ
$
òB
ðOß
$$j
ƒí”
(
@8̯q…[èD
Eƒq˜
$
ðrCz{|öaŽ~Ԁԁ‚
ŸxòBÐ
(
š{×ßÎ
$;P4
2
[
•s^ž¢$
$
Ú Ó
ԃê®NÍq
(
–ê®\)
R#($R($

ƒm<֜®
$
°¹åžö
!:f[
Ô*AiŠ
(
:f[
Ú¿_A¹
;P4
2
[
m<֜®·ä
$
²ÝáB
…æs‹ƒ
;P4
2
[
Ÿ~ޝž…$
$
ŸòÓ_ƒ
;P4
2
[
m~…I‚öƒ›‘
*)+
(
*
$
s’“
G杞…$
;P4
2
[R#(
±Žƒm<ÅÆF
$
ðÚ
µ”
;P4
2
[
ƒÓ_9°
)
&ÙCz{|öaŽ
H?
“}ƒ~Ԁԁ‚$
$;P4
2
[
ƒÓ_¹
;P4
2
[
~…Ÿ•BÖ
$
òÈBœŽÅƃM_
(
;P4
2
[
ðÚ»¼•B‚ƝžöƒÅÆ
$
]
N;P4

$:I4#
Ï
*$4+
(
s’“Åà
$N;P4
ž
:I4#
Ϲ.
H?
“}ƒ~Ԁԁ‚ƒ¨w89
(
ò
?593?f
J\j¹cÓ_m!.EF-XT04@,FE4
d@FTU RC-FTE0 ^E0@AT$93?f
WGƒŠD
$
Ϲž
ƒÊË

‹_

”pµ”

‚Ƶ”Ï•BÊwœ¨
w89
( ?593?f
ÒÓ@8Ü
9ff5$&$#
Ú¿_
AmÊpÓ
$
ŸòÚ¿_ÎЃ@Nm<
*1+
(

*
$
øG
R4?593?f
ðÚµ”–@NƒÓ_×ß
(
s’“Ÿ[Æ
$
Cz{|öaŽ~Ô€Ô
‚̯$
$?593?f
ƒpÓPBœÚ¿_
$
ò
ÈoMm<ƒÅÆF
(
.
?593?f
ðÚÓ_
;P4
2
[
ø
$L>f
3ðÓ_
;P4
2
[
*5+
(
s’“$
$
²‘
?593?f
nlÔåžr
8[1$5($
ƒåži
$
$;P4
2
[
ƒÓ_¡|
R4?593?f
Fƒ#$ò,
Ÿ
$
ٖi+f]‘ij3Žsô+
$
ð:
H?
}~Ԁԁ‚ÒÓ\@8Ú¿_
?593?f
Æß
;P4
2
[
ƒÓ_
(
äò
$
–åžr&ȍÍ#
þ
H?
ƒí”
$
3uHõà
H?
ƒ›‘sks^
?593?f=;P4
2
[
w<@NƒCÐ
(
éCðr
$
+f̯$
$H?
@8pÓ
NI>1$
NI>&=93?f=;P4
2
[=E;O8=;O
w<@N»m~Ô
€Ô‚ƒ¨woM
$
òCz{|öaÍí
H?
ܨCŽ~Ԁԁ‚
(
–$,µrŽ

H?
“}ƒ~Ԁԁ‚’Ÿx¬BÐ
$

§¨CÝÚS‘
(

wx=y
#
* +!8ERR-0T0 ?$ 9@@C--AH:bT0FTC-D$ 1$($ ($!## #(%b
* 1 +!
ӌS
$
^èW
b
Cz{|öaƒ,w’“¹§¨”‘
*V+b
Ëú$A,+k
$ 1$$$ 1&!# #b
* 5 +!
Ø-
$
ÓCê
$
)ŸW
$
Ï
b
Cz{|öa†#í:–s
7Íყ¨’“
*V+b
EKAôk
$ 1$$5$ &5!&#
1(b
* & +!
º±‘
b
Cz{|öa†#Ž~Ԁԁ‚
#)
€
*V+b
$%,W
$ 1$&$ 15!1# 1b
* ( +!
áÁ-
$
5<
$
!­×
$
Ï
b
~Ԁԁ‚

µ_Ԃƒ¹
s7Íá8àƒÖ`’“
*V+b
A§¨’“
$ 1$&!&#
%1b
* # +!
êaà
b
Cz{|öaŽ™xš¯~ÔÎÅԁ‚ƒ
§¨q˜
*V+b
Û5A
$ 1$5$ 5&!)# #&%b
* % +!
áš/
b
{|öaꥁ‰Ž
(1
€~Ԁԁ‚ƒ§
¨’“
*V+b
`¢$A
$ 1$$%$ 1(!%# &%b
* +!
¥G
$
¥Y
b
s7Íá8à¹
N-D
¬z®
*V+b
%pµ_
¨-.
$ 1$$%$ 1%!(# 5%b
* ) +![-DAG@^-d@3$ 9@X0BAA-0 fL$ ?E0@TdZ$ TF@DbPB0,FE-0@D
,-.R@CF.T0F@DEA@FE-0 -\;P4
2
[4@AA-,E@FTU RC-FTE0AE0 3&5 ,TDA
*V+b*$+!IEB S$ JTP$ SE-0XH$ TF@Db:I4QTF@E0UB,TA:I4# RC-UB,FE-0
E0 CTFE0@D9BDTC,TDARCTU-.E0@0FD6FGC-BXG FGT@,FEd@FE-0 -R593?f=;P4^@RR@[AEX0@DE0XR@FG*@6*V+bL7R TA$
1$($ 55!# 115b
*+!YG-B <$ HB@0X9$ SETI$ TF@Db:W:ZE0GEQEFAN;P4@DRG@4E04
UB,TU 99?) T7RCTAAE-0 @0U @,FEdEF6E0 .-0-,6FTAQ6ABRRCTAAE0X
;P4^@RR@[@0U ?593?f@,FEd@FE-0*V+b:0FV1$($ !1# (%)b
*1+!WTXDE@0TAT?$ I-<-,-K$ [@-RG@CT,TRF-CAE0 FGTARE0@D.-F-C0TBC-0A-\.-BAT.-UTDA-\\@4
.EDE@D3I8*V+b9-D*5+!
ì¾
$
O„à
b
ž8‚Æw<@N¥?›‘’“ŸŒ
*V+b
$%¨wÊw-.
$ 1$$($ 1!# #$%b

z{-0
!
‚ƒ„
#
,5$5,