免费文献传递   相关文献

Stability study in biological samples and metabolites analysis of astragaloside Ⅳ in rat intestinal bacteria in vitro

黄芪甲苷的生物样品稳定性考察及在大鼠体外肠菌中代谢转化研究



全 文 :˜ƒˆ°å|ëìÌw‘’É“—æ
ô”•-$Qy–‘àá
ÿÙ

!
@>>

!
.««

!
ŽŒ%

!
.A

!
IK
*
!
?<
!
š@

!
E›A

!
e
XìPdkbc Pkce
!

$$$*% *e
Xìê0ëde Pkì
!

$$$)#

tu
#!
®…ܘƒˆ°
!38C
“å|ëì$Ìw”“—æô”•-Qy–‘a|ÉQyå
)
cuv͓ô”
ÍÎt
38C
“²òÅY
%
²ò•Yɗæšjk$Ìw½É—æ%ô•´-.$Qya|ðcÂÃ
)
͓
MJN<
ÎËÌ
38C
“å|ëc$nÕ
$
¥g
38C
“å|ëc$bÍ2¨„
)
͓
CN<$MJN<
”
N<598=98
;()¨÷œ€
$
ÁÌQya|
)
(óbÈ
$38C
“²òÅY
%
²ò•Yɚy$üSÌ
$
ØiQy
&38C
•´-.Qy¯Aõ;³6²H
ðc
)
ÛF
$
æ
)
ÚU³6–‘È©åQya|N˜ƒ‘
5#5KE

E65
¢£ÓÔ³°
!<9F)
Ãé
$
æ
#
ÚÓÔ³6«¬
½w>: °sN˜ƒ‘
!<3F)
àá(ó¦…
38C
“ô8‚“•´Qy
$
bå³6ç-’“
)
}•´-.ç-’
“¯
38C
Qy‚_7
)

vwx
#!
˜ƒˆ°
&
Ìw
&
ô”
&
•-Qy
&
Qya|
&
Qyå

yz)(
#!*$&5$(5$*

{|}L
#!
%ë¢Ã&6ìîà
!($%)&$$(*%&%%

~€
#!
!
Óè
$CDZ# !$$ (&%)(#($ ?5/GUZ# T^60**%2
*#e-./

€‚ƒ
#!
óÃ&
$
lúàáå
$CDZ#!$$ (&%)(#($?5/GUZ#
V[1S[U72*#e-./
!!
˜ƒ®åNX¤ÜòÜ$,
$
6ìÔ
@
+ªc
«·
A$
ßC^]Wc
%
ñò›)
%
ôàç=
$
†‡ý
þP¤
$
ü-ɜ–zp’“
$
‡)³ÉQʳ´z
Jb¶’“
*+
)
˜ƒˆ°
!38C
ˆn˜ƒ °/
$
®˜ƒ8
‚CÙȨ
**+
) 38C
®—¨© °
$
$-³å
|˜“5ØÉ
)m$
AõˆƒÒ~ÁmÇÍ8g
ÃX‰,-³˜“5
*)5&+
$

38C
G{_
7>Ø*˜
)
à헯àáŒu °Ü|Ž-
³é“ô8bå³6ç-
$
·•´-.–‘é
$
Qya|¹º °s’®‚|Žð¿)Yb
×>—,
*+
)
ô
$
Þt
38C
“ô8G
{Qy–‘ÉY]b×,ÙȨÁuE1C

)

$
cuvÛFt
38C
“Å•Nõ$
Ìwðcàá
$
ÃéÂÃ$ô”QyËw
$
…Ü$Qyõöɖ‘1Ú
$
®¡,”Æ>ì)
ïªbX4uvݸ
)
!
Êû
b!
v?
CTDY/.8-UD1WUXU-
Y;¹ß
5
Žßv
!3--DZGA` =
U`VKDWD-W.Y$ 3--DZG3[W. 8G/IZDY$ 3--DZG#$$
I[/I$ C8LL[G1W[/3--DVV&N<5*$3C
‰ÙY;¹
ßv
!
pcwEF
&
‰À%T•
!
23¥–%T
•v
&CFN*$9
~‰À~%T•
!
8w_ž.%
T•v?CDEF
&C$ OGVU-
V{jk•
!
(%
:@3
EF
& B`>C?cF?;:`8 )
`aCjv
!:@3&
K@b5&$~V9€ð¦…ç‰
!
žI~kuvv
?CDEF
&9C;5*($$K
~ÛòOŽv
!
ŒCË
ùÊv?CDEF
&<
(
8J?
l
!3SUZD1WCD-T1.Z5
.SUDV&
®aa÷;º
5F
–X
!
ðwI–‘òv
)
b!
ö,
38C
”N˜ƒ‘
!<3F
.23m\9å|
()CDEFX4
!
`5
i4(m&
ö)*¤¥
%
‘
?gÿ
F5*$%
Ť¥5”u¤¥5
!
23bzå|()CDEF
&
¼‘~¸5)
!;3KJ;G
*
%
Ó
Ô³
5#5
ٙ¨c
!F5#5J5;G
”ÓÔ³
5#5
ٙ;I
5
!F5#5JKM
®
8US/G

!
$åsCDEF
)
uv$/“$ñöÒü®4š¹ß`Ш÷`
)
u
v“ç®c55`+ç
)
b&!
{|
*íH
8IYGS[DKG+ZD6!8K
—æ
$
ô|
!**$ p
-(*&-

)4
‚
*
r
*$&
n

o
!!!!!! ! ! ! ! ! !!!! ! ! ! !
.`Ze)4$:VV[D!*
;.aD/ODY$ *$&
*$ S$
úÔ23A˜\uv{|()CDEF
$
·ÖŒ<
83
*$5$$*)
!
ÍÎ
b!
vYI–
²òÅY”²ò•Y
#
0ÑMNÍÎ
*#+
–ä
)
38C
4öìxäY–ä
#
l¦ní
38C
âÕ
$
±ˆ‘v-
$
I–ÈŽÕ(5®
e$ S-N
h

38C
xäY
$
°“P“ˆ‘+¼È/ã(5}Ö
)
38C
tÑìvY–ä
#
l¦ní
38C
tÑìâ
Õ
$
±ˆ‘I–ÈŽÕ(5®
$e S-N
h
vY
$
’
®
38C
tÑìvY
)
<3F
tÑìvY–ä
#
l¦ní
<3F
tÑì
âÕ
$
±ˆ‘I–ÈŽÕ(5®
$e S-N
h
vY
$
’®
<3F
tÑìvY
)
b!CN<%MJN<
É
MJN<598
=Ëë›
CN<
Îë›
#

5F
®a–X
$
ñªP¤
#
)
5)
BM5M
*
B!(l)l$$m
(C™Ð‘vY
$ n
±9
/U1
†¹
)
MJN<
ë›
#3SUZD1WC<5<
(
¹ßl
!&e# //o
$ //$
!
/&
=ËÕ8
*$) 1/&
 À
/N-
/U1
h
&
lð®
)$ n&
 {;®Ðƒ
5
ç…5;
$ g
*$ /U1$
Ѓ<*.
)%m
ƒ‘¬
m$
ç<*
.
#)m
ƒ‘¬
&m)
ðëôŽ
)$
!
N)
MJN<598
ë›
#
 {;®Ðƒ
5$e$m
ˆ™
$
Y
;ë›Ù7ît
MJN<
ë›
)
]%©=Ë}8
&
cdV-
) _ &`
cdð5
&$$ n&
¡ ð5
*%$
n&

!;
*
*$&
¸Òò
!3Y&
ðëÕ

!
N)
b&! 38C
Ìw
b&b!38C
“²òÅY$Ìw
!

38C
x
äY
$$
!
N
S
$ /N
ð”Ù
)% n
²òÅYC

$

)% n
€ð¦…çB$
)
èc–ä
)
0
)
ÙP–äر
38C
l¥ëì
)
¨Âԁ½
$$ $e$
$ *$ )$ & T
íë
$
qLPÝí
$e /N)
“íÇ
ëì$tÀ±¿

ôЃþ–½J[J¤¥
$
a
/U1
°þ–l
)
sëì‰À%T
! $$$ Y-
/U1
h
$*$ /U1$
íž*
$MJN<
ðë¨÷
)
b&b!38C
“²ò•Y$Ìw Ù
b&b
³
’
$
s
38C
S²ò•Y©ð”
$
¨ÂÔ
$$ $e$ $
*$ )$ & T
íë
%
îï
)
íž*
$MJN<
ðë¨÷
)
b)!38C
“—æšjk$Qy
b)b!;3KJM
¢{P¤–ä
!
l¦ní
;3KJ5
;G
*
$ F5#5J5;G$ F5#5JKM
”
9S*
âÕ
$
±çv-
JÌì
$
ôPnC
* //.Z-N
h
;3KJ;G
*
$&$ //.Z
-N
h
F5#5J5;G$& A-N
h
F5#5JKM$&$ //.Z-N
h
9S*
$h*$ n
ÆÎ
)
b)b!
ëì–ä
!
0ÑMN
*%+
Ζä—æšj
k
)
ÛF“
?J
$±¿âÕ
38C
ˆ‘vY
$
ç
B׎vÒ
$
±¿
CYUV
à8vY
$
—æšjk
$
a
Cj
)
€ð¦…ç‰
)% n
ð”
/U1)
±¿
;3KJM
¢{P¤
*$$
!
N$
aC)üj½¢{
½
)
½þôŽ®
&$$
!
N$
n
e$ //.Z-N
h
;3K5
J;G
*
$ *$ //.Z-N
h
F5#5J5;G$ * A-N
h
F5#5JKM$
*$ //.Z-N
h
9S*
$
šjk¤¥ŽÕ(5®
*e$ /S
-/N
h
$
»|þ(5®
$
!
/.N-N
h
) )%n
çB¦
…ð”
)
Ôð”
$$ $$ &$$ #$$ *$ /U1
é¨Â±
¿2Ѓ
$e& /N
þ–½
)
qLPÝèc

0
)
b)b&!
ëìîï
!
Ѓþ–½é
$
aJ ò

/U1
°C)üj
$
‰À%T
!) $$$ Y-/U1
h
$*$ /U1$
& n$
íž*
$)% n
çBÛò t׎
)
Š®“
&$$
!
N
ˆ‘Ÿv
$
 ò°v-l
$
‰À%T
!) $$$ Y-
/U1
h
$*$ /U1$& n$
ž*4
MJN<
¨÷
)
b$!38C
ô”•-Qy
%ô&•´-.t
38C
Qy
$
0ÑMN
*(+
Ζä•-&Y
)
í¡1I–•-&Y
©
%
0
$
q0
/N$

38C
4öY
*$
!
N$
Cj
$
JLc–äl¥tÑ
$
¦“€ð
)% n
f¼&
)
Ô
$$ *$ &$ ($ *$ #
”
*& T
íÇ
$
%T
!& $$$ Y
-/U1
h
$ $ /U1 $
Çž*Y
$
“«›‘õ
<
(
8J?
:l`‘
$
séÆØÔ
/N
ˆ‘$
)
4
CN<
Î=ËÉ
MJN<
¨÷
)
Âí
*& T
ð”îï
Y
$e /N$
Ûò t׎
$
 {;
/N
Ÿv
$
‰
À%T
!) $$$ Y-/U1
h
$ )$ /U1 $
íž*“Ô
MJN<598
ËÌ
)
½
$ T
±Ë«
38C
ŽÕ®
$$m$
{½tE
8ðc¥gØÙP
38C
“²òÅY
%
²ò•YÉ
—æšy$bÍ2¨„
)
@s-
W
=-
$
o$$m
@#$
PV
38C
bÍ2¨„
&-
W
#$
PV
38C

ŽÕ
&-
$
#$
P
38C
ŽÕ
)
&!

&b!38C
“²òÅY$Ìw
›r
38C
“²òÅY$mPÝíë¹ßÖ
íŽ
$
¥gØÙP
38C
“²òÅY$bÍ2¨
„
!m)
(óºf
)
-4*&-

)4
‚
*
r
*$&
n

o
!!!!!! ! ! ! ! ! !!!! ! ! ! !
.`Ze)4$:VV[D!*
;.aD/ODY$ *$&
f!38C
“²òÅY$ØÙPbÍ2¨„
!s)
EUSe!>D/GU1U1SYGWD.X38CGWHUXDYD1WWU/DU1 WTDGYWUXU-UGZ
SGVWYU-0[U-D!s)
!!
.
38C
“²òÅY$QyÌwuv(ó
Ö­
$38C
“²òÅY$ϾØbåQy
$
6cÆb
Ì
)
&b!38C
“²ò•Y$Ìw
›r
38C
“²ò•Y$mPÝíë¹ßÖ
íŽ
$
¥gØÙP
38C
“²ò•Y$bÍ2¨
„
!m$
(óºf
*)
f
*!38C
“²ò•Y$ØÙPbÍ2¨„
!s)
EUSe*!>D/GU1U1SYGWD.X38CGWHUXDYD1WWU/DU1 WTDGYWUXU-UGZ
U1WDVWU1GZ0[U-D!s)
!!
.
38C
“²ò•Y$QyÌwuv(ó
Ö­
$38C
“²ò•Y$ϾØbåQy
$
6cÆb
Ì
)
&b&!38C
“—æšjk$Qy
›r
38C
mP¹ßÖÖíŽ
$
¥g
38C
·
ØÙPQyébÍ2¨„
$
ËÌ(óºf
))
(ó†£
$38C
“—æšy$ϾØbåQy
$
Ö1…-³
38C
é
$
ϾišyÛ3Ù½
)
&b)!38C
•-Qy
CN<

.
CN<
f†£
!
f
&$38C
·•´-.Qyé
‚aå
*
LQy|
&
LM&Pô8
$*
LQ
!!
f
)!38C
“—æšjk$ØÙPbÍ2¨„
=m! s

EUSe)!>D/GU1U1SYGWD.X38CGWHUXDYD1WWU/DU1 YGWZUaDYT.5
/.SD1GWD!s
y|Õ²Øä¯
&
·
CN<
†³¨÷µÌ$$¬L
®©åQy|
$
½w“ °S °so
$
¬L®
38C
 °s
<3F)
”
$
.f$ÄÖhÇ
$
LMQyPô8
$
C½w< °s>:|ŽÇÈ
)
¶Ö=¯
38C
b喑åÈ °sé
$
ˆ3ûlQyéaåQ
ya|
)
e38C&*e<3F&) g4e38C
•-Qy
$$*$&$($*$#$*& T
ëì
&
$e
l¥ëì
)
f
&!38C
ØÙP•-Qy|
CN<
f
EUSe&!CN<-TY./GW.SYG/V.XU1WDVWU1GZOG-WDYUG/DWGO.ZUWDV.X
38CGWHUXDYD1WWU/D
&b$!
•-Qy
MJN<
ËÌ
•-Qy|
MJN<
=Ë(óºf
) 38C
mQ
y|¨%²·
$
StÑì38C
·•´-.
’“Ö–‘®¬L©åQy|É°s
<3F&
l¥i
ŽC
)
MJN<
fÖº
38C

*
L‚Qya|
$
$$
¬L® °s
<3F$
¬L®½wÈÔ
38C
S
<3F
o|Ž
) MJN<
=Ë(óS
CN<
(ó6c
¬q
)
-$#*&-

)4
‚
*
r
*$&
n

o
!!!!!! ! ! ! ! ! !!!! ! ! ! !
.`Ze)4$:VV[D!*
;.aD/ODY$ *$&
e38C&*e38C
©åQy|
&)e<3F&3e38C
tÑì
&\e<3F
tÑì
&
•-Qyëì
&Ke
l¥ëì
)
f
!38C
•-Qy
MJN<
f
EUSe!MJN<-TY./GW.SYG/V.XU1WDVWU1GZOG-WDYUG/DWGO.ZUV/.X
38C
&b`!38C
•-Qy|
MJN<598
=ËÉQyå
¨÷
38C
mQya|¨%S·
$
l¥iŽC
)

ìðc¬HŽßlËÌ
$
ma|ê½²·
$
ºf
#)
3,
•-Qyl¥ëì
&\,38C
•-Qy
*& T
ëì
&<,38C

&K,
<3F

&,38C!9$&*,
©åQy|
<9F!9&),<3F!9*)
f
#!38C
É$•-Qy|j%© f
EUSe#!C.WGZU.1 -TY./GW.SYG/.X38CG1H UWVU1WDVWU1GZOG-WDYUG
/DWGO.ZUWDV
!!38C
ɕ-Qy|mPÝ¬HŽß=Ë(
ó®
#$
@
se4* /U1
P
$-=5%(e&$
®
38C
J¨
©%©Ö
*9PM+
P
&$
@
s(e /U1
P
$-=5#)e&$
<
-=5%(e&
QÊ,
)*$
®
38C
æ

¨©U³
/«©åQy|
!<9F*95c6ZPM+
P
&$
@
se$
/U1
P
$-=5)e)&$
<
-=5%(e&
QÊ,
*4&$
®
38C
æ

¨©U³oé3ûæ

¨©ÓÔ³/
« °s
!<3F*95c6Z5FZ-P;G+
P
)
t
38C
ÉQy|¨HŽß=ËbÈ
$38C
øù
=Õ®
*$ Da$
‚~ó%©
-=5#(%$ *4$ &$ &)
Á
&
Qy|
9
øù=Õ®
* Da$
‚~ó%©
-=5
)$ &$ &)%$ &4$ &)
Á
&
Qy|
9*
øù=Õ®
&
Da$
‚~ó%©
-=5&$ )))$ &)
Á
) 38C
ɕ
-Qy|Žß(óºf
% g4)
f
%!38C!9$
¬H
!3
ӬH
!Žßf
EUSe%!JYU/GY6!3 G1H VD-.1HGY6!\ /GVVVID-WY.SYG/.X
38C!9$
f
(!38C
•-Qy|
<9F!9
¬H
!3
ӬH

ßf
EUSe(!JYU/GY6!3 G1H VD-.1HGY6!\ /GVVVID-WY.SYG/.X
38CDVU1WDVWU1GZOG-WDYUG/DWGO.ZUWDV<9F!9
-#*&-

)4
‚
*
r
*$&
n

o
!!!!!! ! ! ! ! ! !!!! ! ! ! !
.`Ze)4$:VV[D!*
;.aD/ODY$ *$&
f4!38C
•-Qy|
<3F!9*
¬H
!3
ӬH

ßf
EUSe4!JYU/GY6!3 G1H VD-.1HGY6!\ /GVVVID-WY.SYG/.X
38CfVU1WDVWU1GZOG-WDYUG/DWGO.ZUWDV<9F!9*
!!
Žß(ó†£
$38C
·•´-.–‘é
$*

‚Qya|¨Â®æU³6´åÈ©åQy
|
<9F
Ӿ
*
L³6«¬ °s
<3F)
Žß
ë-G…fºf
$)
¦
!38C
•-Qy|Žßk;
CGOZD!9GVVVID-WY./DWY6U1X.Y/GWU.1 .XU1WDVWU1GZOG-WDYUG
/DWGO.ZUWDV.X38C
‘)|
$
>
=/U1
-N5
38C!9$ e4*
*9PM+
P
%(e&
<9F!9 (e
*95c6ZPM+
P
#)e&
<3F!9* e$
*95c6Z5FZ-P;G+
P
)e)&
!!
A)
CN<$MJN<
É
N<598=98
(ó¨÷
$38C
·•´-.’“Qy«¬;³6Qya|
$
$¨
æ
)
Ú6ÂU³©åQy|
<9F!9$
¬
L®ð¬³æ
#
ÚÓÔ³«¬½w>: °
s
<3F!9*) 38C
ô”Qyå
$
ºf
)
)!
Ã:
38C
“²òÅ
%
•Y$Ìw‘’(ó†£
!!
f
$!38C
Žßë-G…f
EUSe$!EUS[YD.XWTD98 -ZDGaGSDY[ZDV.X38C
$“Å•Y$üSÌ
)

38C
—æ%ô• ´-.Qy¨÷
$

38C
Öl–‘®æ
)
ÚU
-*#*&-

)4
‚
*
r
*$&
n

o
!!!!!! ! ! ! ! ! !!!! ! ! ! !
.`Ze)4$:VV[D!*
;.aD/ODY$ *$&
!!
9$e38C&9e
©åQy|
<9F&9*e<3F)
f
!38C
·•´-.Qyå
EUSe!9DWGO.ZU-IGWT+G6V.X38CU1 WTDU1WDVWU1GZXZ.YG
³6
<9F
”ð¬³æ
#
ÚÓÔ³«¬½w
>: °s
<3F)
®ð¬³Ä¼
38C
“ô8
QyËw
$
cuvÙP‘ÂÃ,—æšyt
38C

Qyéê
)
(ó†£
$38C
“—æšy$ϾØb
åQy
)
>[U5;GbT.[
Á3Ô
38C
·—æ•´-.Qy
M—
*4+
¦…,
38C
“ô8–‘® °sÉ °
s㤙
$
ð¬³rŒ,cDE(ó
)
cuv“
—æ%ô•´-.Qyàá64ž
$
t
38C
—æ
ô”šQyÉ$“²òÅ
%
•Y$ÌwÁüð
c,‘’
$
Œu,
38C
“ô8¯l•´-.ç-
$
åÈ,;³6Qya|
$
ð´”$Qya|©Ùð
¿)YÔN9´b×,ْ“
)
.cuv(óÖ+Ë
$38C
“Å•´8G{

$
Ö·•´-.–‘bå³6ç-’“
$
K
“šy$ϾØlQy
$
-³éiÛ3Ù½
)
(
)cDE±ô8”Qyuv(ó
$

38C
”$
Qya|©Ùð¿)YÔNb×,ْ“
)
Z
G{¿)ՔmQya|tb×,Ù˜N—
:‘ãð¬³àá
)

„…†‡
#
*+!
F›[
e
$,˜ƒ,àáðñ
*]+e
R2$B,-.
$
*$)$)!##%)e
**+!

$
4c
$
ón…
e
,|)*8˜ƒˆ°nÕËÌÉ$œ
–
M8›wäWuvàá
*]+e
$\$B,a
$*$$*4
!*# *%%$e
*)+!F[ R-T$ QG1SF]$JG1 FR$DWGZeCYG1VI.YWG1H OU.GaGUZGOUZUW6
VW[HUDV.XGVWYGSGZ.V.HD
/
G1 G-WUaDU1SYDHUD1WU1 >GHU73VWYGSGZU
*]+e\GVU-*&+!
!>
e
˜ƒˆ°¤‹6
5)-
Ngl¹)|“—æô8å|
˜“5
*]+,
$%,ö
$*$$$)!&#,
*+!
ÓFh
$
Ài^
$
Óô
$
Á
e
•´-.t$,°ÜȨQy
àáðñ
*]+e
$,Ê
$*$$)&!%#e
*#+!
$%,¸
e
¨1
*8+e*$$e
*%+!
,Í)
$
D7
$
Fj
$
Á
e
£{B¬
3
“—æšjk$Qy
a|
*]+e
\L,-.
$*$$4$*&!)#*4(e
*(+!
õÜg
$
y¾å
$
¢Ã_
$
Á
e
ú±Ÿ¨TȨkÖp°•-
Qyàá
*]+e
Œ$B,
$*$$%$*&!##e
*4+!bT.[ >;$ 8.1SRN$ >[G1 ]L$ DWGZeJTGY/G-._U1DWU-DaUHD1-D
.1 WTD-.1WYUO[WU.1 .XU1WDVWU1GZOG-WDYUGZ-.1aDYVU.1 W.OD1DXU-UGZ
DXD-WV.XGVWYGSGZ.VUHD:`$ G/GY_DY-./I.[1H .X3VWYGSGZU>GHU7$
U1 WYGHUWU.1GZ.YGZ[VD.XWTDTDYO*]+eKY[S9DWGO JTGY/$*$*$
*%!##(#e
-)#*&-

)4
‚
*
r
*$&
n

o
!!!!!! ! ! ! ! ! !!!! ! ! ! !
.`Ze)4$:VV[D!*
;.aD/ODY$ *$&
;B-K./.BD IBGFD .AK.@/@S.R-/I-,M/?I-AF,?B-K@/.B?I-A-/DI.I@L
-IBE-S-/@I.F?
/
.AE-B.AB?IB.A-/K-RB?E.- #01#%.
8A;F[U57UG

$ bM3BR[G156[G1

$ 9:3BJDU5IDU

$ R3;FcUG.56G1

$ 9:3BLU1S

$ N:]U1S
*
$
cA?\G.50[G1

$ 8A]U1

$ bM3;FR[50UD

!
!e239&&/&089!)4)I97%-73*$ C)!*Q%71!$!&7/89!)4):)1!3!)6!4()47%*$ C)!*4KIBE-RB+!C.XUS[YD.[WWTDVWGOUZUW6G1H U1WDVWU1GZOG-WDYUG/DWGO.ZUWDV.XYGWV! #!$%&.XGVWYGSGZ.VUHD
/
!38C$ WTUVYDVDGY-T
+GVH.1DW.D7IZ.YDWTDVWGOUZUW6.X38CU1 WTDGYWUXU-UGZSGVWYU-0[U-DGYWUXU-UGZU1WDVWU1GZ0[U-DG1H YGWZUaDYT./.SD1GWDG1H WTD/DWGO.5
ZUV/U1 YGWU1WDVWU1GZ! #!$%&eMJN<+GV[VDH W.-GZ-[ZGWDWTDYD/GU1U1SYGWD.X38CU1 OU.Z.SU-GZVG/IZDVO6/DGV[YU1SWTD-.1WD1W.X
38C$ +TUZD/DWGO.ZUWDV+DYDHDWDY/U1DH O6-./OU1U1SWTD/DWT.HV.XCN<$MJNW./DWGO.ZU^DU1 WTDGYWUXU-UGZSGVWYU-0[U-D$ GYWUXU-UGZU1WDVWU1GZ0[U-DG1H YGWZUaDY,3ZV.$ WTD/DWGO.ZU-IGWT+G6.X38C+GVVWDIIDH O6
HDSZ6-.V6ZGWU.1eEUYVWZ6$ 38C+GV-.1aDYWDH W.UWVVD-.1HGY6DWGO.ZUWDV!#5KE

E65SZ[-.I6YG1.V6Z5-6-Z.GVWYGSD1.Z$<9F O6YD/.aGZ.X
76Z.VD/.UDW6GW<5)$WTD1 WYG1VX.Y/DH U1W.-6-Z.GVWYGSD1.Z!<3F GXWDYT6HY.Z6WU-YD/.aGZ.XWTDSZ[-.VD/.UDW6GW<5#e3ZWTDYDV[ZWV
V[SSDVWDH WTGWWTD/DWGO.ZUV/.X38C! #!#&.--[YV/GU1Z6U1 WTDU1WDVWU1GZO6T6HY.Z6VUV.XSZ6-.V6Ze:1 -.1-Z[VU.1$ T6HY.Z6VUV.XU1WDV5
WU1GZXZ.YGUVWTD/GU1 YDGV.1 WTGW38C/DWGO.ZU^DVe
*W?D T@EFI+!GVWYGSGZ.VUHD
/
& VWGOUZUW6& ! #!$%&& /DWGO.ZUV/O6U1WDVWU1GZOG-WDYUG& /DWGO.ZUWDV& /DWGO.ZU-IGWT+G6V
F@.#(a)`ZPRYR,,()&&

ˆ‰-0
!
š››
#
-&#*&-

)4
‚
*
r
*$&
n

o
!!!!!! ! ! ! ! ! !!!! ! ! ! !
.`Ze)4$:VV[D!*
;.aD/ODY$ *$&