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作 者 ：陈乐天,狄留庆,刘卉,单进军,赵晓莉,周伟,蔡宝昌

期 刊 ：中国中药杂志 2011年 36卷 7期 页码：935.

关键词：瑞香素；甘草提取物；药代动力学；相互影响；

Keywords:daphnetin, glycyrrhiza extract, pharmacokinetics, transaction,

摘 要 ：目的: 研究甘草提取物对祖师麻主要活性成分瑞香素大鼠体内药代动力学特征参数的影响,探索其配伍用药的合理性。 方法 :大鼠分别灌胃给药瑞香素和含有同等剂量瑞香素的甘草提取物,LC-MS分析测定血浆中瑞香素浓度,经DAS 2.1.1程序处理数据。 结果 :甘草提取物能够减小瑞香素t1/2, tmax和K_e,增加K_a和AUC_0~∞ 。 结论 :甘草能促进祖师麻中瑞香素的口服吸收,减慢其消除,提高其生物利用度。

Abstract:Objective : To research the influence of glycyrrhiza extract on the pharmacokinetics characteristic parameters of daphnetin, which was aimed to explore the rationality of concert application of drugs. Method : The rats received intragastric administration of daphnetin and glycyrrhiza extract containing the same daphnetin respectively. The blood concentration of daphnetin was assayed by LC-MS. The data was processed by program DAS2. 1. 1. Result : Glycyrrhiza extract can reduce the t1/2, tmax and K_e of daphnetin, while increased the K_a and AUC_{0~ ∞}. Conclusion : Glycyrrhiza extract promoted the oral absorption of daphnetin, slowed down the elimination and increased the biological availability.

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