作 者 :解笑瑜,王瑞,师彦平
期 刊 :中国中药杂志 2013年 38卷 14期 页码:2325.
关键词:天南星科 ;千年健 ;化学成分 ;
Keywords:Araceae , Homalomena occulta , chemical constituents ,
摘 要 :采用正相硅胶柱色谱、葡聚糖凝胶SephadexLH-20柱色谱、重结晶等方法对中药千年健进行了化学成分研究,并运用波谱方法对所分离得到的化合物进行结构鉴定。结果从中药千年健中分离并鉴定了12个化合物,分别为5-pentylresorcinol-β -glucoside(1 ),原儿茶酸(2 ),对羟基苯甲酸(3 ),香草酸(4 ),5-羟甲基-2-呋喃甲酸(5 ),2-呋喃甲酸(6 ),5-羟甲基-2-糠醛(7 ),(R )-苹果酸(8 ),(R )-苹果酸二甲酯(9 ),1,2,3-丙烷三羧酸三甲酯(10 ),4-羟基-四氢呋喃-2-酮(11 )和三羟基薄荷烷(12 )。其中,化合物1 为新的天然产物,化合物4~12 为首次从该属植物中分离得到。
Abstract:Column chromatography on silica gel and Sephadex LH-20 was used to study the chemical constituents of Homalomena occulta . The chemical structures of the separated compounds were elucidated by spectroscopic data analyseS.Twelve compounds were obtained and identified as 5-pentylresorcinol-b-glucoside(1 ), protocatechuic acid(2 ), 4-hydroxybenzoic acid(3 ), vanillic acid(4 ), 5-hydroxymethyl-2-furancarboxylic acid(5 ), 2-furoic acid(6 ), 5-hydroxymethyl-2-furfural(7 ),(R )-malic acid(8 ),(R )-dimethyl malate(9 ), trimethyl 1,2,3-propanetricarboxylate(10 ), 4-hydroxytetrahydrofuran-2-one(11 ) and (1S ,2S ,4S )-p -menthane-1,2,4-triol(12 ). Among them, compound 1 was a new natural product, and compounds 4-12 were isolated from the genus for the first time.
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