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作 者 ：蒋富强,张雪梅,马云保,耿长安,江志勇,陈纪军

期 刊 ：中国中药杂志 2011年 36卷 16期 页码：2215.

关键词：毛萼獐牙菜；口山酮；裂环烯醚萜；

Keywords:Swertia hispidicalyx, xanthones, secoiridoids,

摘 要 ：目的: 对龙胆科 Gentianaceae 獐牙菜属植物毛萼獐牙菜 Swertia hispidicalyx Burk. 的干燥全草进行化学成分研究。 方法: 采用各种柱色谱进行分离纯化,通过波谱数据分析 (MS,¹H-,¹³C-NMR) 进行结构鉴定。 结果: 从乙酸乙酯萃取部分分离鉴定了11个化合物,其中2个口山酮,2个裂环烯醚萜,2个三萜,2个甾体,以及3个其他类化合物,它们分别鉴定为1,3,5,8-四羟基口山酮 (1,3,5,8-tetrahydroxyxanthone, 1),1,5,8-三羟基-3-甲氧基口山酮 (1,5,8-trihydroxy-3-methoxyxanthone, 2),龙胆内酯 (gentiolactone, 3),獐牙菜苦苷(swertiamarin, 4),3,4-dihydro-1H,6H,8H-naphtho dipyrano-1,8- dione (5),(+)-丁香脂素 6)],松柏醛 (trans-coniferyl aldehyde, 7),山楂酸 (maslinic acid, 8),齐墩果酸 (oleanolic acid, 9),胡萝卜苷 (daucosterol, 10), β-谷甾醇 (β-sitosterol, 11)。 结论: 化合物 1~11 均为首次从毛萼獐牙菜中分离得到。

Abstract:Objective: To study the chemical constituents of Swertia hispidicalyx. Method: The EtOAc part of S. hispidicalyx was chromatographied by various column chromatography methods, and the isolates were identified based on spectroscopic analyses (MS, ¹H-and ¹³C-NMR). Result: Eleven compounds were isolated from S. hispidicalyx and characterized as 1,3,5,8-tetrahydroxyxanthone (1), 1,5,8-trihydroxy-3-methoxyxanthone (2), gentiolactone (3), swertiamarin (4), 3,4-dihydro-1H,6H,8H-naphtho[1,2-c:4, 5-c‘, d‘]dipyrano-1,8-dione (5), (+)-syringaresinol (6), trans-coniferyl aldehyde (7), maslinic acid (8), oleanolic acid (9), daucosterol (10), and -sitosterol (11). Conclusion: Compounds 1-11 were obtained from S. hispidicalyx for the first time.

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