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期 刊 ：中国中药杂志 2008年 33卷 16期 页码：2029.

关键词：复方；配伍；模拟；正交设计；药物相互作用；

Keywords:compound, simulation, orthogonal design, drug interactions,

摘 要 ：目的:建立一种药效学相互作用的定量计算方法和模拟方法,用以分析复方的配伍规律。方法:根据复方的组分数,采用相应的正交设计;1水平为"高剂量,"2水平为"低剂量"。并用一个实例对此模型进行了考证;模拟偏倚由两种散点图结合评价。结果:本法可计算各组分不同剂量水平对复方药效贡献大小,从而确定最佳的组方;还可分析各配伍组的相互作用性质和交互效应;采用的复方效应模型,可对不同剂量水平组合的复方进行药效模拟,由散点图来评价预测的准确程度。结论:本法将定量分析方法和计算机模拟相结合,具有可行性,能为同类研究和二次文献分析等提供一个新的方法。

Abstract:Objective: An approach is set up to calculate pharmacodynamic interaction and simulate the combined response. Method: An orthogonal design with 1-level=high dose and 2-level=low dose was adopted. An example of the compound with four components was applied to evaluate this quantitative approach. The bias was evaluated by the both scatter plots. Result: This approach can calculate the value of each component with different dose by its contribution to combined response, and the value is related to the importance of a compound. Drug interactions were evaluated among the combinations in each group. The prediction model performed well and simulated the combined response in the different of components in combination. Conclusion: The approach can be used in the similar research, and it also provides predictions of component combinations from the other studies by simulation.

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